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DOI: 10.1007/BF02043500
© Georg Thieme Verlag KG Stuttgart · New York
Alteration in Mg2+ content of red blood cells from patients with diuretic therapy
Presented at The 35th World Congress, International College of Angiology, Copenhagen, Denmark, July 1993Publikationsverlauf
Publikationsdatum:
22. April 2011 (online)
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Abstract
Hypomagnesemia can cause ventricular tachycardia, cardiac necrosis, or torsades de pointes. Diuretic treatment can result in Mg2+ depletion, as many diuretics inhibit the reabsorption of filtered Mg2+ in the proximal or distal tubule. As plasma Mg2+ constitutes only about 3% of total body Mg2+ stores, intracellular Mg2+ determinations may be more useful for assessing total body Mg2+ content. Therefore we studied the effect of a thiazide diuretic (trichlormethiazide 4 mg/day), a combination of a thiazide and a potassium-sparing diuretic (trichlormethiazide and amiloride 2 mg/day each), and the loop diuretic piretanide (6 mg/day) on intracellular Mg2+ in patients with mild essential hypertension before and after 6 and 10 weeks of therapy. Mg2+ measurements were performed in blood plasma and in red blood cells by atomic absorption spectroscopy, using a Video 12 apparatus. There was a significant decrease in intracellular Mg2+ content under trichlormethiazide therapy (p<0.05). Furthermore, our results show that diuretic treatment with a combination of a thiazide and a potassium-sparing diuretic or with the loop diuretic piretanide may have the advantage of avoiding intracellular Mg2+ depletion.