Int J Angiol 1995; 4(1): 46-50
DOI: 10.1007/BF02043508
Original Articles

© Georg Thieme Verlag KG Stuttgart · New York

Holographic interferometry for In Vitro investigation of bioprosthetic valves

Armin W. Geiger1 , Alexander M. Zarubin2 , Marc Hertel1 , Anke Fahrenkamp3 , Gert von Bally2 , Hans H. Scheld1
  • 1Department of Thoracic and Cardiovascular Surgery, University of Muenster, Muenster, Germany
  • 2Institute of Experimental Audiology, Laboratory of Biophysics, University of Muenster, Muenster, Germany
  • 3Institute of Pathology, University of Muenster, Muenster, Germany
Presented at the 35th World Congress, International College of Angiology, Copenhagen, Denmark, July 1993
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Publikationsverlauf

Publikationsdatum:
22. April 2011 (online)

Abstract

Dysfunction of heart valve prostheses—mechanical as well as biological—is a common problem in cardiac surgery. The reasons for the valve failures are still not well understood. Biological valves especially have an unsatisfactory durability; degeneration and calcification very often lead to the failure of the valves. In our opinion, hidden defects present in the valve material prior to implantation of the valves is a plausible explanation for the dysfunction. Hitherto there has been no technique to detect these defects without destructing the specimen. Holographic interferometry proved to be applicable for in vitro evaluation of mechanical heart valve prostheses. In the present paper we describe application of this method to biological valves. Nine porcine bioprostheses and four fresh porcine aortic valves were investigated by means of holographic interferometry. In eight of nine bioprostheses, the results showed irregularities of the leaflet structure which depend on anomalies of the connective tissue of the leaflets of the valves. To make sure that these findings are not due to normal variations of the morphology, the investigations were carried out with fresh and unfixated porcine aortic valves. In the latter, no such anomalies of the structure were detected. The results obtained confirm the above hypothesis on the origin of the later valve dysfunction. Thus, holographic interferometry tests of bioprostheses prior to their implantation prevent the use of potentially dysfunctional valves.