Download PDF
Int J Angiol 1995; 4(2): 88-93
DOI: 10.1007/BF02043624
Original Articles

© Georg Thieme Verlag KG Stuttgart · New York

The role of MHC class I and class II molecules in susceptibility to Lyme disease in inbred B10 H-2 congenic and recombinant mice

Sunitha Reddy1 , Colin R. Young2 , Regina Hokanson2 , Julie Rawlings3 , Chella S. David4
  • 1Department of Biology, Texas A&M University, College Station, Texas
  • 2Department of Veterinary Pathobiology, Texas A&M University, College Station, Texas
  • 3Texas Department of Health, Austin, Texas
  • 4Department of Immunology, Mayo Clinic, Rochester, Minnesota, USA
Presented at the 35th Annual World Congress, International College of Angiology, Copenhagen, Denmark, July 1993
Further Information

Publication History

Publication Date:
22 April 2011 (online)

  PDF Download  Permissions and Reprints

Abstract

We have further developed the mouse model of Lyme disease using B10 H-2 congenic and recombinant strains. The influence of MHC class I and class II genes of the mouse H-2 complex on the susceptibility and/or resistance to Lyme disease was studied. We report that B10 strains congenic to the haplotypes, H-2k, H-2d, H-2f, H-2q, and H-2b are highly susceptible to Lyme disease as they develop high antibody titers and severe disease over mice of other haplotypes used in this study. By using recombinant strains we demonstrate that this susceptibility is genetically based and specifically involves the K and D regions (MHC class I genes) and I-A and I-E regions (MHC class II genes) of the H-2 complex.