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Int J Angiol 1995; 4(2): 88-93
DOI: 10.1007/BF02043624
DOI: 10.1007/BF02043624
Original Articles
© Georg Thieme Verlag KG Stuttgart · New York
The role of MHC class I and class II molecules in susceptibility to Lyme disease in inbred B10 H-2 congenic and recombinant mice
Presented at the 35th Annual World Congress, International College of Angiology, Copenhagen, Denmark, July 1993Weitere Informationen
Publikationsverlauf
Publikationsdatum:
22. April 2011 (online)
![](https://www.thieme-connect.de/media/ija/199502/lookinside/thumbnails/10.1007-BF02043624-1.jpg)
Abstract
We have further developed the mouse model of Lyme disease using B10 H-2 congenic and recombinant strains. The influence of MHC class I and class II genes of the mouse H-2 complex on the susceptibility and/or resistance to Lyme disease was studied. We report that B10 strains congenic to the haplotypes, H-2k, H-2d, H-2f, H-2q, and H-2b are highly susceptible to Lyme disease as they develop high antibody titers and severe disease over mice of other haplotypes used in this study. By using recombinant strains we demonstrate that this susceptibility is genetically based and specifically involves the K and D regions (MHC class I genes) and I-A and I-E regions (MHC class II genes) of the H-2 complex.