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CC BY-NC-ND 4.0 · Journal of Fetal Medicine 2016; 03(02): 97-100
DOI: 10.1007/s40556-016-0081-3
Brief Communication

Fraser Syndrome: Prenatal Detection at 16 Weeks of Gestation

Lakshmy Ravi Selvaraj
1   Shri Lakshmi Scan Centre, 185/386-A, Govindhachetty Street, N.C.R. Complex, Kaveripattinam, 635112, Krishnagiri, Tamilnadu, India
,
Shahid Yakoob
2   Department of Radiology, Vinayaka Mission’s Kirupananda Variyar Medical College and Hospitals, Salem, Tamilnadu, India
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Abstract

Fraser syndrome is a rare autosomal recessive disorder characterized by syndactyly, renal abnormalities, genital malformation, and in some cases, cryptophthalmos. This syndrome had been diagnosed in the second pregnancy of a 22-year-old woman at 22 weeks of gestation based on prenatal scan, postnatal clinical examination, and autopsy findings. The third pregnancy was uneventful. In the fourth pregnancy, features of Fraser syndrome were evident in the first trimester 11–14 week aneuploidy scan. A review scan at 16 weeks of gestation confirmed the findings of Fraser syndrome. Early ultrasound diagnosis of recurrence of this syndrome as early as 16 weeks of gestation is highlighted.

Keywords

Fraser syndrome - Cryptophthalmos syndrome - CHAOS - Renal agenesis - Consanguinity


Publication History

Received: 29 October 2015

Accepted: 02 March 2016

Article published online:
08 May 2023

© 2016. Society of Fetal Medicine. This is an open access article published by Thieme under the terms of the Creative Commons Attribution-NonDerivative-NonCommercial-License, permitting copying and reproduction so long as the original work is given appropriate credit. Contents may not be used for commercial purposes, or adapted, remixed, transformed or built upon. (https://creativecommons.org/licenses/by-nc-nd/4.0/)

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