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CC BY-NC-ND 4.0 · Journal of Fetal Medicine 2018; 05(03): 163-165
DOI: 10.1007/s40556-018-0175-1
Original Article

Early Second-Trimester Spontaneous Miscarriage Due to Fourth Ventricle Choroid Plexus Papilloma

George S. Stoyanov 
1   Department of General and Clinical Pathology, Forensic Medicine and Deontology, Faculty of Medicine, Medical University – Varna “Prof. Dr. Paraskev Stoyanov”, Hristo Smirnenski 1 Blvd., 9002, Varna, Bulgaria
2   Department of Anatomy and Cell Biology, Faculty of Medicine, Medical University – Varna “Prof. Dr. Paraskev Stoyanov”, Varna, Bulgaria
3   Department of Physiology and Pathophysiology, Faculty of Medicine, Medical University – Varna “Prof. Dr. Paraskev Stoyanov”, Varna, Bulgaria
,
Ina Kobakova
1   Department of General and Clinical Pathology, Forensic Medicine and Deontology, Faculty of Medicine, Medical University – Varna “Prof. Dr. Paraskev Stoyanov”, Hristo Smirnenski 1 Blvd., 9002, Varna, Bulgaria
,
Dimo Stoyanov
2   Department of Anatomy and Cell Biology, Faculty of Medicine, Medical University – Varna “Prof. Dr. Paraskev Stoyanov”, Varna, Bulgaria
,
Marin Zhelezov
2   Department of Anatomy and Cell Biology, Faculty of Medicine, Medical University – Varna “Prof. Dr. Paraskev Stoyanov”, Varna, Bulgaria
,
Meglena Angelova
2   Department of Anatomy and Cell Biology, Faculty of Medicine, Medical University – Varna “Prof. Dr. Paraskev Stoyanov”, Varna, Bulgaria
,
Deyan Dzhenkov
1   Department of General and Clinical Pathology, Forensic Medicine and Deontology, Faculty of Medicine, Medical University – Varna “Prof. Dr. Paraskev Stoyanov”, Hristo Smirnenski 1 Blvd., 9002, Varna, Bulgaria
,
Reneta Georgieva
4   Faculty of Medicine, Medical University – Varna “Prof. Dr. Paraskev Stoyanov”, Varna, Bulgaria
,
Lora Ayetola
4   Faculty of Medicine, Medical University – Varna “Prof. Dr. Paraskev Stoyanov”, Varna, Bulgaria
,
Emil Kovachev
5   Department of Obstetrics and Gynecology, Faculty of Medicine, Medical University – Varna “Prof. Dr. Paraskev Stoyanov”, Varna, Bulgaria
,
Peter Ghenev
1   Department of General and Clinical Pathology, Forensic Medicine and Deontology, Faculty of Medicine, Medical University – Varna “Prof. Dr. Paraskev Stoyanov”, Hristo Smirnenski 1 Blvd., 9002, Varna, Bulgaria
,
Anton B. Tonchev
2   Department of Anatomy and Cell Biology, Faculty of Medicine, Medical University – Varna “Prof. Dr. Paraskev Stoyanov”, Varna, Bulgaria
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Abstract

Miscarriage due to fetal tumors is an extremely rare finding, with a varying incidence from 1.7 to 13.5 per 100,000 live births, with central nervous system tumors occupying a minority of these cases. Herein, we report the gross morphological and histological findings of a 17-gestational week spontaneous miscarriage in a 27 year old multi-gravida due to a fourth ventricle choroid plexus papilloma (CPP). The CPP was composed of a pronoun fibro-vascular stroma covered with a dense lining of tall cuboid sparsely ciliated single cell layer with rich in chromatin nuclei. The cytoplasm of the CPP covering cells was intensely colored when compared to the pale cytoplasm of the covering cells of the choroid plexus collected from the lateral ventricle, which also lacked in such pronoun fibrovascular stroma. The fourth ventricle was significantly dilated with parenchymal compression of nervous tissue towards the chondral fetal cranium.

Keywords

Spontaneous miscarriage - Fetal tumor - Choroid plexus papilloma - Turner syndrome


Publication History

Received: 13 April 2018

Accepted: 04 May 2018

Article published online:
08 May 2023

© 2018. Society of Fetal Medicine. This is an open access article published by Thieme under the terms of the Creative Commons Attribution-NonDerivative-NonCommercial-License, permitting copying and reproduction so long as the original work is given appropriate credit. Contents may not be used for commercial purposes, or adapted, remixed, transformed or built upon. (https://creativecommons.org/licenses/by-nc-nd/4.0/)

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