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CC BY-NC-ND 4.0 · Journal of Fetal Medicine 2020; 07(01): 9-16
DOI: 10.1007/s40556-019-00228-4
Review Article

Current Status of Noninvasive Prenatal Testing and Counselling Considerations: An Indian Perspective

James D. Massa
1   Medical Affairs, Illumina, Inc., 5200 Illumina Way, 92122, San Diego, CA, USA
,
Veronica Arora
2   Institute of Medical Genetics and Genomics, Sir Ganga Ram Hospital, Rajender Nagar, 110060, New Delhi, India
,
Meenakshi Lallar
2   Institute of Medical Genetics and Genomics, Sir Ganga Ram Hospital, Rajender Nagar, 110060, New Delhi, India
,
Sunita Bijarnia
2   Institute of Medical Genetics and Genomics, Sir Ganga Ram Hospital, Rajender Nagar, 110060, New Delhi, India
,
Ratna Dua Puri
2   Institute of Medical Genetics and Genomics, Sir Ganga Ram Hospital, Rajender Nagar, 110060, New Delhi, India
,
Ishwar C. Verma
2   Institute of Medical Genetics and Genomics, Sir Ganga Ram Hospital, Rajender Nagar, 110060, New Delhi, India
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Abstract

Uptake of noninvasive prenatal testing (NIPT) is rapidly expanding around the world. Here, we provide an overview of the current global state of NIPT, describe the expansion of the test menu, highlight alternative prenatal test service delivery, and discuss NIPT counseling considerations. We also provide a perspective on utilisation of NIPT in India, which has unique challenges for implementing NIPT given its large population, vast territory, and diverse ethnic groups. The barriers to implementation of NIPT in India are also discussed. Current recommendations regarding use of NIPT made by professional societies vary in different regions and such recommendations for NIPT in India will be helpful to provide general guidance to the health care providers, but will likely require modifications for implementation in India.

Keywords

Noninvasive prenatal testing (NIPT) - Noninvasive prenatal screening (NIPS) - Cell-free DNA (cfDNA) - India - Counselling - Prenatal Diagnosis Techniques Act - Limitations - Guidelines


Publication History

Received: 12 September 2019

Accepted: 29 October 2019

Article published online:
05 May 2023

© 2019. Society of Fetal Medicine. This is an open access article published by Thieme under the terms of the Creative Commons Attribution-NonDerivative-NonCommercial-License, permitting copying and reproduction so long as the original work is given appropriate credit. Contents may not be used for commercial purposes, or adapted, remixed, transformed or built upon. (https://creativecommons.org/licenses/by-nc-nd/4.0/)

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