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CC BY-NC-ND 4.0 · Journal of Fetal Medicine 2021; 08(01): 65-70
DOI: 10.1007/s40556-020-00283-2
Brief Communication

Prenatal Binder Phenotype: Physician’s Dilemma-A Case Report

Ashutosh Gupta 
1   Foetal Medicine and Medical Genetics, Artemis Hospitals, Sector 51, 122001, Gurgaon, India
,
Anjila Aneja
2   Department of Minimal Access Surgery (Gynecology), Fortis Memorial Research Institute, Gurgaon, Sector 44, 122001, Gurgaon, India
,
Neena Bahl
2   Department of Minimal Access Surgery (Gynecology), Fortis Memorial Research Institute, Gurgaon, Sector 44, 122001, Gurgaon, India
,
Rupam Arora
3   Department of Obstetrics and Gynecology, Max Balaji Hospital, 108 A, Indraprastha extension, 110092, Patparganj, New Delhi, India
,
Renu Raina Sehgal
4   Department of Obstetrics and Gynecology, Artemis Health Institute, Sector 51, 122001, Gurgaon, India
,
Pankaj Saini
5   Department of Radiology, Manipal Hospitals, Sector 6, 110075, Dwarka, New Delhi, India
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Abstract

The Binder phenotype is defined by midface hypoplasia, underdeveloped frontal sinuses, hypoplastic and abnormally positioned nasal bones, nostrils appearing moon or comma-shaped and prognathism. It is heterogeneous in etiology and not fully understood. Multiple causative factors are described. The physician’s dilemma is of diagnosing the fetal abnormalities on antenatal ultrasound for which there is no confirmatory testing. There are management and ethical problems regarding the diagnosis, further investigations and confirmation of the diagnosis. The Binder phenotype is a clinical diagnosis with multiple differential diagnoses. It carries an uncertain and unpredictable course and prognosis which might be difficult for both clinician and parents to predict and comprehend. Genetic counseling has to be variable depending upon the diagnosis.

Keywords

Binder phenotype - Midface hypoplasia - Uncertain - Unpredictable course - Genetic counseling - Chondrodysplasia punctata teratogens


Publication History

Received: 07 July 2020

Accepted: 28 November 2020

Article published online:
05 May 2023

© 2021. Society of Fetal Medicine. This is an open access article published by Thieme under the terms of the Creative Commons Attribution-NonDerivative-NonCommercial-License, permitting copying and reproduction so long as the original work is given appropriate credit. Contents may not be used for commercial purposes, or adapted, remixed, transformed or built upon. (https://creativecommons.org/licenses/by-nc-nd/4.0/)

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