Suppression of alpha adrenergic agonist-induced catalepsy in mice by potentized Agaricus muscarius

Abstract

Agaricus muscarius 30c, a potentized homoeopathic drug prepared by successive dilution with 90% ethanol followed by sonication in 30 steps, suppressed catalepsy induced by alpha adrenergic agonists in Swiss albino mice. Agaricus produced anticataleptic effect when it was administered orally and no such effect when administered intraperitoneally. The alpha 1 agonist phenylephrine and alpha 2 agonist clonidine were administered intraperitoneally to mice at a dose of 2 mg/kg and 1 mg/kg, respectively. Mice were pretreated orally with Agaricus muscarius 30c. The action of Agaricus is thought to be mediated through ororeceptors.

Keywords

Alpha agonists - Phenylephrine - Clonidine - Catalepsy - Homoeopathic potency - Agaricus muscarius - Oral route - Anticataleptic - Ultrasonic - Ororeceptor