Hypertonic Saline In Traumatic Brain Injury: Current Status

Abstract

Traumatic brain injury is among the leading causes of mortality today. Systemic hypotension and intracranial hypertension are major contributors towards morbidity and mortality in these patients. The primary goal of resuscitation is to maintain adequate blood pressure while attenuating the expected rise in intracranial pressure. The type of fluid to be used for this is much debated even today. Mannitol is the most popular agent, but there are limitations to its administration. Interest is now focusing on the utility of other hyperosmolar agents like hypertonic saline, that combat raised intracranial pressure and support intravascular volume. However, no standards exist regarding its indications or optimal administration regimen in the treatment of traumatic brain injury. A review of literature regarding the postulated mechanism of action and current status of its role in traumatic brain injury is discussed.

Keywords

head injury - hypertonic saline - traumatic brain injury - intracranial pressure - resuscitation

• References

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