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DOI: 10.1016/S0973-0508(10)80005-X
Spinal cord regeneration
Verantwortlicher Herausgeber dieser Rubrik:
Publikationsverlauf
Publikationsdatum:
05. April 2017 (online)
Abstract
Research in spinal cord regeneration is catching attention of clinicians and basic scientists. It would almost revolutionise the life and disease outcome of these unfortunate patients if we can work out a cost effective and practical treatment regimen for these victims who are unfortunately in the prime of their productive years. It was gratifying to learn that nerves in peripheral nervous system (PNS), which are outside the brain or spinal cord, did regrow. It is exciting to learn that the prospects of regrowth of spinal cord improves when these PNS cells are implanted in damaged spinal cord. Spinal cord injury is a global epidemic. A lot of research is going on in this field. Axonal regeneration, electric stimulation, Netrins, stem cells etc are few exciting fields in the area of research. It is ongoing research whereby the ability to grow human motor neurons in the laboratory will provide new insights into disease processes and could be used as alternative to animal models for finding therapeutic targets and testing drugs.
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References
- 1 Edwin Smith papyrus. 1550 B.C.E. Rare Book Room of New York Academy of Medicine.
- 2 Vikhanski Luba. Thinking the Unthinkable About Spinal Cord Regeneration. In Search of the Lost Cord: Solving the Mystery of Spinal Cord Regeneration. 2001. Joseph Henry Press; Washington:
- 3 Spinal Cord Injury Information Network Online. Research for the Cure in Spinal Cord Injury: History of Cure Research. http://www.spinalcord.uab.edu/show.asp?durki=47987 .
- 4 United Nations Population Division. Total world population report. 2009. WHO; Geneva:
- 5 National Spinal Cord Injury Association. Report on injuries in the United States. 2009. NSCIA; Washington:
- 6 International Campaign for Cures of Spinal Cord Injury Paralysis Online. General Information. http://www.campaignforcure.orgl/iccp/index.php?option=com_content&task=view&id=13&Itemid=28 Wisegeek. Is spinal cord regeneration possible? http://www.wisegeek.com/is-spinal-cord-regeneration-possible.htm
- 7 Maier IC, Ichiyama RM, Courtine G. et al Differential effects of anti-Nogo-A-antibody treatment and treadmill training in rats with incomplete spinal cord injury. Brain 2009; 132: 1426-1440
- 8 Schwab ME, Bartholdi D. Degeneration and regeneration of axons in the lesioned spinal cord. Physiology Review 1996; 76: 319-370
- 9 Raineteau O, Fouad K, Noth P, Thallmar M, Schwab ME. Functional switch between motor tracts in the presence of the mAb IN-1 in the adult rat. Proc National Academy Science USA 2001; 98 n 6929-6934
- 10 Maisonpierre PC, Le Beau MM, Espinosa 3rd R. et al Human and rat brain-derived neurotrophic factor and neurotrophin-3: gene structures, distributions, and chromosomal localizations. Genomics 1991; 10: 558-568
- 11 Tuszynski M., Blesch A. Nerve growth factor: from animal models of cholinergic neuronal degeneration to gene therapy in Alzheimer’s disease. Brain 2001; 146: 79-123
- 12 Sun W, Sun C, Lin H, Zhao H, Wang J, Ma H. et al The effect of collagen-binding NGF-beta on the promotion of sciatic nerve regeneration in a rat sciatic nerve crush injury model. Biomaterials 2009; 27: 4649-4656
- 13 Woodbury D, Schwarz EJ, Prockop DJ, Black IB. Adult rat and human bone marrow stromal cells differentiate into neurons. J Neurosci Res 2000; 61: 364-370
- 14 Marcos S, Backer S, Causeret F, Tessier-Lavigne M, Bloch-Gallengo E. Differential roles of Netrin-1 and its receptor DCC in inferior olivary neuron migration. Mol Cell Neurosci 2009; 41: 429-439
- 15 Borgens RB, Shi RY. Immediate recovery from spinal cord injury through molecular repair of nerve membranes with polyethylene glycol. FASEB J 2000; 14: 27-35
- 16 Miya D, Tessler A, Giszter S, Mori F, Murray M. Fetal transplants alter the development of function after spinal cord transection in newborn rats. J Neurosci 1997; 17: 4856-4872
- 17 Borgens R, Toombs J, Breur G. et al An imposed oscillating electrical field improves the recovery of function in neurologically complete paraplegic dogs. J Neurotrauma 1999; 16: 639-657
- 18 Bracken MB, Shephard MJ, Holford TR. et al Methylprednisolone or trilazad mesylate administration after acute spinal cord injury: 1-year follow up. Results of the third National Acute Spinal Cord Injury randomised controlled trial. JAMA 1997; 277: 1597-1604
- 19 Brewer KL, Bethea JR, Yeziers RP. Neuroprotective Effects of Interleukin-10 Following Excitotoxic Spinal Cord Injury. Experimental Neurology 1999; 159: 484-493
- 20 DeForge D, Nymark J, Lemaire E. et al Effect of 4-aminopyridine on gait in ambulatory spinal cord injuries: a double-blind, placebo-controlled, crossover trial. Spinal Cord 2004; 42: 674-685
- 21 Tuszynski MH, Senut MC, Ray J, Roberts J, U H.-S. Gage FH. Somatic gene transfer to the adult primate CNS: In vitro and In vivo characterization of cells genetically modified to secrete nerve growth factor. Neurobiol Dis 1994; 01: 67-78
- 22 Olsen Lars, Cheng Henrich, Cao Yihai. Steps towards healing damaged spines. Science News 1996; 150: 52-53
- 23 Adams RA, Bauer J, Flick MJ, Sikorski SL, Nuriel T, Lanssman H. et al The fibrin-derived γ377-395 peptide inhibits microglia activation and suppresses relapsing paralysis in central nervous system autoimmune disease. The Journal of Experimental Medicine 2002; 204: 571-582
- 24 Houle JD, To m VJ, Mayes D, Wagoner G, Phillips N, Silver J. Combining an autologous peripheral nervous system “bridge” and matrix modification by chondroitinase allows robust, functional regeneration beyond a hemi section lesion of the adult rat spinal cord. J Neurosci 2006; 26: 7405-7415
- 25 Dong-Hyuk Park, David J Eve, Paul R Sanberg, et al. Induction of neuronal proliferation in the dentate gyrus of aged rats by grafted human neural stem cells. Proceedings of 2nd international Congress of Asia Oceania Neurotrauma Society 2010.
- 26 Sang Ryong Jeon, Hyung Il Seo Joong Kee Min, Seong Who Kim. Therapeutic effects of Wnt secreting fibroblast implantation in spinal cord injury of rat. Proceedings of 2nd international Congress of Asia Oceania Neurotrauma Society 2010.
- 27 Okano H, Sawamoto K. Neural Stem Cells: involvement in adult neurogenesis and CNS repair. Phil Trans R Soc B 2008; 363: 2111-2122