Multiple Choice Question – Pharmacotherapy of Epilepsy

• Q.1 Which of the following Anti-Epileptic Drugs (AEDs) should be avoided in an ICU patient who is on meropenem for pneumonia?

  • A) Sodium Valproate

  • B) Levetiracetam

  • C) Lacosamide

  • D) Midazolam

• Q.2 All of the following AEDs except one are consider to be enzyme-inducing AEDs

  • A) Phenytoin

  • B) Carbamazepine

  • C) Primidone

  • D) Sodium Valproate

• Q.3 The proposed mechanism of action for Levetiracetam is:

  • A) Modifies synaptic release of glutamate and GABA through action on vesicular function

  • B) Enhances slow inactivation of voltage-gated Sodium Channels

  • C) Inhibits Carbonic Anhydrase

  • D) Irreversibly inhibits GABA aminotransferase

• Q.4 Rufinamide is indicated for

  • A) Adjunctive treatment of focal epilepsy

  • B) Adjunctive treatment of the Lennox-Gastaut Syndrome

  • C) Generalized tonic-clonic seizures

  • D) Status Epilepticus

• Q.5 Which of the following side-effects can be attributed to Topiramate?

  • A) Nephrolithiasis

  • B) Gingival hyperplasia

  • C) Hemorrhagic Pancreatitis

  • D) Weight gain

• Q.6 Fatal cases of aplastic anemia have been reported with use of the following AEDs:

  • A) Levetiracetam and Pregablin

  • B) Carbamazepine and Felbamate

  • C) Lacosamide and tiagabine

  • D) Phenytoin and phenobarbital

• Q.7 Ethosuximide is indicated for treatment of:

  • A) Focal epilepsy

  • B) Generalized tonic-clonic seizures

  • C) Generalized non-motor (absence) seizures

  • D) Unclassified epilepsy

• Q.8 Idiosyncratic reactions of Valproate include all of the following except

  • A) Hepatotoxicity

  • B) Pancreatitis

  • C) Thrombocytopenia

  • D) Psychosis

• Q.9 Chronic dose-related adverse effects of valproate include all of the following except

  • A) Weight gain

  • B) Hair loss

  • C) Peripheral neuropathy

  • D) Endocrine and metabolic changes

• Q.10 Vigabitrin is indicated for myoclonic epilepsy

  • A) True

  • B) False