Anti-inflammatory activity of Arnica montana 6cH: preclinical study in animals

S.B Macêdo; L.R Ferreira; F.F Perazzo; J.C Tavares Carvalho

doi:10.1016/j.homp.2004.02.006

Homeopathy, Inhaltsverzeichnis

Homeopathy 2004; 93(02): 84-87
DOI: 10.1016/j.homp.2004.02.006

Original Paper

Anti-inflammatory activity of Arnica montana 6cH: preclinical study in animals

Autor*innen

S.B Macêdo

¹Faculdade de Odontologia, Pontifı́cia Universidade Católica de Brası́lia, Brası́lia, Brazil
L.R Ferreira

²Instituto de Med. Veterinária, Campus Poços de Caldas, Pontifı́cia Universidade Católica de Poços de Caldas, Minas Gerais, Brazil
F.F Perazzo

³Laboratório de Fitofármacos, Universidade de Alfenas, Rod. MG 179, km 0, CP 23, CEP 37130-000, Alfenas, Minas Gerais, Brazil
J.C Tavares Carvalho

³Laboratório de Fitofármacos, Universidade de Alfenas, Rod. MG 179, km 0, CP 23, CEP 37130-000, Alfenas, Minas Gerais, Brazil

⁴Faculdade de Ciências da Saúde de São Paulo (FACIS-IBEHE), S. Paulo, Brazil

Verantwortlicher Herausgeber dieser Rubrik:

Abstract

The anti-inflammatory effect of Arnica montana 6cH was evaluated using acute and chronic inflammation models. In the acute, model, carrageenin-induced rat paw oedema, the group treated with Arnica montana 6cH showed 30% inhibition compared to control (P<0.05). Treatment with Arnica 6cH, 30 min prior to carrageenin, did not produce any inhibition of the inflammatory process. In the chronic model, Nystatin-induced oedema, the group treated 3 days previously with Arnica montana 6cH had reduced inflammation 6 h after the inflammatory agent was applied (P<0.05). When treatment was given 6 h after Nystatin treatment, there was no significant inhibitory effect. In a model based on histamine-induced increase of vascular permeability, pretreatment with Arnica montana 6cH blocked the action of histamine in increasing vascular permeability.

Keywords

Arnica montana 6 cH - anti-inflammatory activity - preclinical

Volltext

Referenzen

References
1 Gibson DM. Arnica, a study. Br Hom J 1972; 61: 167–170.
2 Tetau M. Matéria Médica Homeopática—Clı́nica e Associações Bioterápicas. Organização Andrei Ltda., S. Paulo, Brazil 1987, pp 67–69.
3 Edward H. Arnica montana. The Flora Homoeopathic. New Delhi: B. Jain Publishers, 1988, pp 36–44.
4 Blackwood AL. Matéria Médica, Terapeutica y Farmacologia Homeopática. International Homeophatic Medical Organization, 3^a edição, Mexico: B. J. Publishires Ltda., 1990, pp 143–144.
5 Tyler ML. Retratos de Medicamentos Homeopáticos. Livraria e Editora Santos S. Paulo, Brazil 1992, pp 92–99.
6 Bucay JW. Algumas notas sobre la planta medicinal Arnica montana L. Rev Med Inst Mex Seg Soc 1995; 33(3): 312–326.
7 Wagner VH. Immunstimulierend wirkende Polysacchaide (Heteroglykane) aus höheren Pflanzen. Arzneimittel Forschung 1984; 34(6): 659–661; 1985; 35(7): 1069–1075.
8 Wagner H, Jurcic K. Immunologische untersuchungen von pflanzlichen kombinationspräparaten. Neimittelforschung 1991; 41(10): 1072–1076.
9 Puhlmann J, Zenk MH, Wagner H. Immunologically active polysaccharides of Arnica montana cell cultures. Phytochemistry 1991; 30(4): 1141–1145.
10 Schröder H. Helenalin an 11,13-dihydrohelenalin, two constituents from Arnica montana L., inhibit human platelet function via thiol-dependent pathways. Thromb Res 1990; 57: 839–845.
11 Quezada RM. Coloquio de farmacodinamica homeopatica. Arnica Montana. La Homeop Mexico 1987; 507: 13–17.
12 Farmacopéia Homeopática Brasileira, S. Paulo: Editora Andrei, 1977, 115pp.
13 Mustard JF, Movat JZ, Macmorine DRL, Senyi A. Release of permeability factors from blood platelet. Proc Soc Exp Biol Med 1965; 119: 981–988.
14 Lykbe AMJ, Cummings R. Inflammation in healing. 1. Time- course and medition of exudation in wound healing in the rat. Brit J Exp Pathol 1969; 50: 309–318.
15 Di Rosa M, Willoughby DA. Screens for anti-inflammatory drugs. J Pharm Pharmcol 1971; 23: 297–298.
16 Schiatti P, Selva D, Arrigoni-Martelli E. L’edema localizzato da nystatin come modello di inflammazione sperimentale. Boll Chim Farm 1970; 109: 33–38.
17 Trowbridge HO, Emling RC. Mediadores quı́micos da resposta vascular. Inflamação uma revisão do processo, Vol 27–42. S. Paulo: Quintessence Publishing Co. Inc., 1996, 172p.
18 Carmine TC. Effects of high potencies of tumour necrosis factor alpha on H20 production in cultured neuroblastoma cells by enhanced luminol-dependent chemiluminescence (ECL). A possible system for investigating the biological significance of homoeopathic high potencies. Br Hom J 1997; 86: 67–72.