RSS-Feed abonnieren
Bitte kopieren Sie die angezeigte URL und fügen sie dann in Ihren RSS-Reader ein.
https://www.thieme-connect.de/rss/thieme/de/10.1055-s-00037682.xml
![](/products/assets/desktop/img/oa-logo.png)
CC BY-NC-ND 4.0 · International Journal of Epilepsy 2017; 04(01): 012-018
DOI: 10.1016/j.ijep.2016.12.001
DOI: 10.1016/j.ijep.2016.12.001
Research paper
Recurrence rate and risk factors for recurrence of seizures after withdrawal of antiepileptic drugs (AED) in Indian children treated for epilepsy
Weitere Informationen
Publikationsverlauf
Received: 01. Juli 2016
Accepted: 05. Dezember 2016
Publikationsdatum:
06. Mai 2018 (online)
![](https://www.thieme-connect.de/media/10.1055-s-00037682/201701/lookinside/thumbnails/10-1016-j-ijep-2016-12-001-1.jpg)
-
References
- 1 Kale R. Global campaign against epilepsy: the treatment gap. Epilepsia 43 (56) 2002; 31
- 2 Specchio LM, Beghi E. Should antiepileptic drugs be withdrawn in seizure-free patients?. CNS Drugs 18 (04) 2004; 201-212
- 3 Olmez A, Arslan U, Turanli G. et al. Risk of recurrence after drug withdrawal in childhood epilepsy. Seizure 18 2009; 251-256
- 4 Verriotti A, D’Egidio C, Agostinelli S. et al. Antiepileptic drug withdrawal in childhood epilepsy: what are the risk factors associated with seizure relapse. Arch Dis Child 96 2011; 113-115
- 5 Magdy AA, Siam AG. Effect of the duration of withdrawal of antiepileptic drugs on the risk of seizure recurrence in childhood epilepsy. Egypt J Neurol Psychiat Neurosurg 47 (04) 2010; 593-598
- 6 Bouma PAD, Peters ACB, Brouwer OF. Long term course of childhood epilepsy following relapse after antiepileptic withdrawal. J Neurol Neurosurg Psychiatry 72 2002; 507-510
- 7 Altunbasak S, Artar O, Burgut R. et al. Relapse risk analysis after drug withdrawal in epileptic children with uncomplicated seizures. Seizure 8 1999; 384-389
- 8 Shinnar S, Berg AT, Moshe SL. Discontinuing antiepileptic drugs in children with epilepsy: a prospective study. Ann Neurol 35 1994; 534-545
- 9 Pavlovic M, Jovic N, Pekmezovic T. Antiepileptic drugs withdrawal in patients with IGE. Seizure 20 September (7) 2011; 520-525
- 10 Andersson T, Braathen G, Persson A. et al. A comparison between one and three years of treatment in uncomplicated childhood epilepsy: a prospective study. II. The EEG as predictor of outcome after withdrawal of treatment. Epilepsia 38 (02) 1997; 225-232
- 11 Caviedes BE, Herranz JL. Seizure recurrence and risk factors after withdrawal of chronic antiepileptic therapy in children. Seizure 7 (02) 1998; 107-114
- 12 Ohta H, Ohtsuka Y, Tsuda T. et al. Prognosis after withdrawal of antiepileptic drugs in childhood-onset cryptogenic localisation related epilepsies. Brain Dev 26 (01) 2004; 19-25
- 13 Sillanpaa M, Schmidt D. Prognosis of seizure recurrence after stopping antiepileptic drugs in seizure free patients: a long term population based study of childhood onset epilepsy. Epilepsy Behav 8 2006; 713-719
- 14 Berg AT, Shinnar S. Relapse following discontinuation of antiepileptic drugs: a meta-analysis. Neurology 44 1994; 601-608
- 15 Britton J. Antiepileptic drug withdrawal: literature review. Mayo Clin Proc 77 2002; 1378-1388
- 16 Verma A, Mishra S. Risk of seizure recurrence after antiepileptic withdrawal, an Indian study. Neurol Asia 11 2006; 19-23
- 17 Lamdhade SJ, Taori GM. Study of factors responsible for recurrence of seizures in controlled epileptics for more than 1.5 years after withdrawal of antiepileptic drugs. Neurol India 50 2002; 295-300
- 18 Medical Research Council Antiepileptic Drug Withdrawal Study Group. Randomised study of antiepileptic drug withdrawal in patients in remission. Lancet 337 1991; 1175-1180
- 19 Boonluksiri P. Risk of seizure recurrence after antiepileptic drug withdrawal in Thai children with epilepsy. Neurol Asia 11 2006; 25-29
- 20 Ramos-Lizana J, Aguirre-Rodriguez J, Aguilera-Lopez P. et al. Recurrence risk after withdrawal of antiepileptic drugs in children with epilepsy: a prospective study. Eur J Pediatr Neurol 14 (02) 2010; 116-124
- 21 Pavlovic M, Jovic N, Pekmezovic T. Antiepileptic drugs withdrawal in patients with idiopathic generalized epilepsy. Seizure 20 (07) 2011; 520-525
- 22 Pavlovic M, Jovic N, Pekmezovic T. Withdrawal of antiepileptic drugs in young patients with cryptogenic focal epilepsies. Seizure 21 (06) 2012; 431-436
- 23 Lossius MI, Hessen E, Mowinckel P. et al. Consequences of antiepileptic drug withdrawal: a randomized Double Blind Study (Akhershus Study). Epilepsia 49 2008; 455-463
- 24 Hawash KY, Rosman NP. Do partial seizures predict an increased risk of seizure recurrence after antiepilepsy drugs are withdrawn?. J Child Neurol 18 (05) 2003; 331-337
- 25 Prognostic index for recurrence of seizures after remission of epilepsy. Medical Research Council Antiepileptic Drug Withdrawal Study Group. BMJ 306 1993; 1374-1378
- 26 Bonnett LJ, Shukralla A, Tudur-Smith C. Seizure recurrence after antiepileptic drug withdrawal and the implications for driving: further results from the MRC Antiepileptic Drug Withdrawal Study and a systematic review. J Neurol Neurosurg Psychiatry 82 2011; 1328-1333
- 27 Incecik F, Herguner OM, Altunbasak S. et al. Risk of recurrence after discontinuation of antiepileptic drug therapy in children with epilepsy. J Pediatr Neurosci 9 (02) 2014; 100-105
- 29 Speechio LM, Tramacere L, La Neve A. et al. Discontinuing antiepileptic drugs in patients who are seizure free on monotherapy. J Neurol Neurosurg Psychiatry 72 (01) 2002; 22-25
- 30 Hitiris N, Mohanraj R, Norrie J. et al. Predictors of pharmaco-resistant epilepsy. Epilepsy Res 75 2007; 192-196
- 31 Peters AC, Brouwer OF, Geerts AT. et al. Randomized prospective study of early discontinuation of antiepileptic drugs in children with epilepsy. Neurology 50 1998; 724-730
- 32 Cockerell OC, Johnson AL, Sander JW. et al. Prognosis of epilepsy: a review and further analysis of the first nine years of British national General practice. Study of epilepsy: a prospective population based study. Epilepsia 38 1997; 31-46
- 33 Dooley J, Gordon K, Camfield P. et al. Discontinuation of anticonvulsant therapy in children free of seizures for 1 year: a prospective study. Neurology 46 1996; 969-974
- 34 Mohanraj R, Brodie MJ. Diagnosing refractory epilepsy: response to sequential treatment schedules. Eur J Neurol 13 2006; 277-282
- 35 Tinuper P, Avoni P, Riva R. et al. The prognostic value of the electroencephalogram in antiepileptic drug withdrawal in partial epilepsies. Neurology 47 1996; 76-78
- 36 Avoni P, Riva R, Tinuper P. Prognosis of epilepsies in antiepileptic drugs discontinuation. Epilepsia 37 suppl (04) 1996; 58-59
- 37 Braathen G, Melander H. Early discontinuation of treatment in children with uncomplicated epilepsy: a prospective study with a model for prediction of outcome. Epilepsia 38 1997; 561-569
- 38 Sillanpaa M, Jalava M, Kaleva O. et al. Long term prognosis of seizures with onset in childhood. N Engl J Med 338 1998; 1715-1722
- 39 Berg AT, Shinnar S, Levy SR. et al. Two year remission and subsequent relapse in children with newly diagnosed epilepsy. Epilepsia 42 2001; 1253-1262
- 40 Hixson JD. Stopping antiepileptic drugs: when and why. Curr Treat Options Neurol 12 2010; 434-442
- 41 Tennison M, Greenwood R, Lewis D. et al. Discontinuing antiepileptic drugs in children with epilepsy: a comparison of a 6 week and a 9 month taper period. N Engl J Med 330 1994; 1407-1410
- 42 Sirven JL, Sperling M, Wingerchuk DM. Early versus late antiepileptic drug withdrawal for people with epilepsy in remission. Cochrane Database Syst Rev. 3 2002
- 43 MacDonald BK, Johnson AL, Goodridge DM. et al. Factors predicting prognosis of epilepsy after presentation with seizures. Ann Neurol 48 2000; 833-841
- 44 Arts WF, Brouwer OF, Peters AC. et al. Course and prognosis of childhood epilepsy: 5 year follow-up of the Dutch study of epilepsy in childhood. Brain 127 2004; 1774-1784
- 45 Delgado MR, Riela AR, Mills J. et al. Discontinuation of antiepileptic drug treatment after two seizure free years in children with cerebral palsy. Pediatrics 97 1996; 192-197
- 46 Andersson T, Brathen G, Persson A. et al. A comparison between one and three years of treatment in uncomplicated childhood epilepsy: a prospective study, II: the EEG as predictor of outcome after withdrawal of treatment. Epilepsia 38 1997; 225-232
- 47 Serra J, Montenegro M, Guerreiro M. Antiepileptic drug withdrawal in childhood: does the duration of tapering off matter for seizure recurrence?. J Child Neurol 20 (07) 2005; 624-626
- 48 Guerra S, Augusta M, Guerreiro M. Antiepileptic drug withdrawal in childhood. Does the duration of tapering off matter for seizure recurrence?. J Child Neurol 20 (07) 2005; 624-626
- 49 Ranganathan LN, Ramaratnam S. Rapid versus slow withdrawal of antiepileptic drugs. Cochrane Database Syst Rev (02) 2006; CD005003
- 50 Elson L. Predictors of outcome in newly diagnosed epilepsy: clinical, EEG and MRI. Neurol Asia 16 (01) 2011; 27-29
- 51 Camfield PR, Camfield CS. Childhood epilepsy: what is the evidence for what we think and what we do. J Child Neurol 18 2003; 272-287