Eccentric Overload Muscle Damage is Attenuated By a Novel Angiotensin- (1-7) Treatment

Lenice Kappes Becker; Nádia Totou; Samara Moura; Lucas Kangussu; Ruben Dario Sinisterra Millán; Maria Jose Campagnole-Santos; Daniel Coelho; Daisy Motta-Santos; Robson Augusto Souza Santos

doi:10.1055/a-0633-8892

International Journal of Sports Medicine, Table of Contents

Int J Sports Med 2018; 39(10): 743-748
DOI: 10.1055/a-0633-8892

Physiology & Biochemistry

Eccentric Overload Muscle Damage is Attenuated By a Novel Angiotensin- (1-7) Treatment

Authors

Lenice Kappes Becker

³Sports Department, School of Physical Education, Physiotherapy, and Occupational Therapy (EEFFTO), Federal University of Minas Gerais, Brazil

¹National Institute of Science and Technology in Nanobiopharmaceutics, Department of Physiology and Biophysics, Institute of Biological Sciences, Federal University of Minas Gerais, Brazil
Nádia Totou

²Sport Center, Federal University of Ouro Preto, Ouro Preto, Brazil
Samara Moura

²Sport Center, Federal University of Ouro Preto, Ouro Preto, Brazil
Lucas Kangussu

³Sports Department, School of Physical Education, Physiotherapy, and Occupational Therapy (EEFFTO), Federal University of Minas Gerais, Brazil
Ruben Dario Sinisterra Millán

¹National Institute of Science and Technology in Nanobiopharmaceutics, Department of Physiology and Biophysics, Institute of Biological Sciences, Federal University of Minas Gerais, Brazil

⁴Department of Chemistry, Universidade Federal de Minas Gerais, Belo Horizonte, Brazil
Maria Jose Campagnole-Santos

¹National Institute of Science and Technology in Nanobiopharmaceutics, Department of Physiology and Biophysics, Institute of Biological Sciences, Federal University of Minas Gerais, Brazil
Daniel Coelho

²Sport Center, Federal University of Ouro Preto, Ouro Preto, Brazil
Daisy Motta-Santos

¹National Institute of Science and Technology in Nanobiopharmaceutics, Department of Physiology and Biophysics, Institute of Biological Sciences, Federal University of Minas Gerais, Brazil

³Sports Department, School of Physical Education, Physiotherapy, and Occupational Therapy (EEFFTO), Federal University of Minas Gerais, Brazil
Robson Augusto Souza Santos

¹National Institute of Science and Technology in Nanobiopharmaceutics, Department of Physiology and Biophysics, Institute of Biological Sciences, Federal University of Minas Gerais, Brazil

Abstract

The development of new strategies to attenuate exercise-induced muscle damage may be helpful for training regimens. The aim of this study was to determine whether a oral formulation of angiotensin Ang-(1-7)[HPβCD/Ang-(1-7)] is effective to reduce pain, and muscle damage markers after eccentric-overload exercise. HPβCD (Placebo) and HPβCD/Ang-(1-7) (Ang-(1-7) group were treated for 7 days (one capsule/day). The pain was measured by visual analogue scale, maximal strength (MS) using force platform. Blood samples were collected for cytokines and creatine kinase (CK) analysis. The Ang-(1-7)-treated group reported less pain immediately (3.46±0.64 vs. placebo 3.80±0.77 cm) and 24 h after exercise (3.07±0.71 vs. 3.73±0.58 cm placebo) and higher MS at 24 h (24±12 N) and 48 h (30±15 N) vs. placebo (-8±9 N and -10±9 N). The CK for Ang-(1-7) (0.5±0.1 and 0.9±0.2 U/L) were lower at 48 and 72 h vs. placebo (fold changes of 1.7±0.5 and 1.5±0.3 U/L). The TNF-α level was lower in the treated group post-exercise (38±2.5 pg/ml) vs. placebo (45±2.9 pg/ml) but no significant changes were observed for IL-6 and IL-10. Our data indicate that treatment with Ang-(1-7) may attenuate pain, some of the muscle damage markers and improves performance following eccentric exercise.

Key words

physical performance - angiotensin-(1-7) - muscular damage

Full Text

References

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