Sepsis – jede Minute zählt?

Internationale und deutsche Sepsisleitlinien empfehlen, bei einer (schweren) Sepsis eine antibiotische Therapie möglichst innerhalb 1 Stunde nach Diagnosestellung zu beginnen [1], [2]. Bisher gab es hierzu keine randomisierte Interventionsstudie.

• Literatur

• 1 Levy MM, Evans LE, Rhodes A. The Surviving Sepsis Campaign Bundle: 2018 Update. Crit Care Med 2018; 46: 997-1000
• 2 Reinhart K, Brunkhorst FM, Bone HG. et al. German Sepsis Society, German Interdisciplinary Association of Intensive Care and Emergency Medicine. Prevention, diagnosis, therapy and follow-up care of sepsis: 1st revision of S-2 k guidelines of the German Sepsis Society (Deutsche Sepsis-Gesellschaft e. V. (DSG)) and the German Interdisciplinary Association of Intensive Care and Emergency Medicine (Deutsche Interdisziplinäre Vereinigung für Intensiv- und Notfallmedizin (DIVI)). Ger Med Sci 2010; 8: Doc14
• 3 Alam N, Oskam E, Stassen PM. et al. PHANTASi Trial Investigators and the ORCA (Onderzoeks Consortium Acute Geneeskunde) Research Consortium the Netherlands. Prehospital antibiotics in the ambulance for sepsis: a multicentre, open label, randomised trial. Lancet Respir Med 2018; 6: 40-50
• 4 Kumar A, Roberts D, Wood KE. et al. Duration of hypotension before initiation of effective antimicrobial therapy is the critical determinant of survival in human septic shock. Crit Care Med 2006; 34: 1589-1596
• 5 Singer M. Antibiotics for Sepsis: Does Each Hour Really Count, or Is It Incestuous Amplification?. Am J Respir Crit Care Med 2017; 196: 800-802