Ustekinumab – eine Standortbestimmung

Britta Siegmund; Christoph Högenauer; Gottfried Novacek; Wolfgang Petritsch; Walter Reinisch; Alain Schoepfer; Stefan Schreiber; Stephan Vavricka; Bernd Bokemeyer; für die IBD-Dach-Gruppe

doi:10.1055/a-0655-2425

Zeitschrift für Gastroenterologie, Table of Contents

Z Gastroenterol 2018; 56(09): 1077-1086
DOI: 10.1055/a-0655-2425

Übersicht

Ustekinumab – eine Standortbestimmung

Ustekinumab – Current position

Britta Siegmund

¹Charité – Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, Medizinische Klinik für Gastroenterologie, Infektiologie und Rheumatologie, Berlin, Germany

,

Christoph Högenauer

²Klinische Abteilung für Gastroenterologie und Hepatologie, Universitätsklinik für Innere Medizin, Medizinische Universität Graz, Österreich

,

Gottfried Novacek

³Medizinische Universität Wien, Universitätsklinik für Innere Medizin III, Klinische Abteilung für Gastroenterologie und Hepatologie, Wien, Österreich/Austria

,

Wolfgang Petritsch

²Klinische Abteilung für Gastroenterologie und Hepatologie, Universitätsklinik für Innere Medizin, Medizinische Universität Graz, Österreich

,

Walter Reinisch

³Medizinische Universität Wien, Universitätsklinik für Innere Medizin III, Klinische Abteilung für Gastroenterologie und Hepatologie, Wien, Österreich/Austria

,

Alain Schoepfer

⁴Centre hospitalier universitaire vaudois, Service de gastro-énterologie et dʼhépatologie, Lausanne, Schweiz

,

Stefan Schreiber

⁵Klinik für Innere Medizin I, Universitätsklinikum Schleswig-Holstein, Campus Kiel, Kiel

,

Stephan Vavricka

⁶Zentrum für Gastroenterologie und Hepatologie, Zürich, Schweiz

,

Bernd Bokemeyer

⁷Gastroenterologische Gemeinschaftspraxis Minden

,

für die IBD-Dach-Gruppe

› Author Affiliations

Abstract

Zusammenfassung

Die vorliegende Übersicht der IBD-Dach-Gruppe legt eine Übersicht zu Wirkmechanismus, klinischer Entwicklung, Zulassung, Wirksamkeit und Sicherheitsaspekten des neuen Anti-p40-Antikörpers Ustekinumab vor, der für die Therapie des moderaten bis schweren Morbus Crohn zugelassen ist. Die Arbeit fasst die aktuelle Datenlage zusammen und enthält somit sowohl die Daten der Zulassungsstudien als auch die Daten aus kleineren und auch fachübergreifenden Arbeiten, mit denen die Aspekte zu besonderen Situationen diskutiert werden können. Alle Arbeiten zusammen zeigen, dass mit Ustekinumab eine wirksame und sichere Option für den Morbus Crohn zur Verfügung steht.

Abstract

The present review by the IBD-Dach group provides a comprehensive summary of the mode of action, clinical development, approval, efficacy and safety aspects of the novel anti-p40 antibody Ustekinumab. The review provides current data, including the large clinical trials as well as smaller case series and work outside the field of inflammatory bowel diseases for shedding more light into special situations. Together, the data indicate that Ustekinumab shows clinical efficacy as well as a good safety profile for the treatment of Crohnʼs disease.

Schlüsselwörter

chronisch-entzündliche Darmerkrankung - Morbus Crohn - Biologika - Ustekinumab

Key words

inflammatory bowel disease - Crohn’s disease - biologicals - ustekinumab

Full Text

References

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