Changes in Serum Immunoglobulin G4 Levels in Patients with Newly Diagnosed Graves’ Disease

Izumi Hiratsuka; Hiroya Yamada; Mitsuyasu Itoh; Megumi Shibata; Takeshi Takayanagi; Masaki Makino; Yoshihisa Sugimura; Nobuki Hayakawa; Shuji Hashimoto; Atsushi Suzuki

doi:10.1055/a-0669-9333

Experimental and Clinical Endocrinology & Diabetes, Inhaltsverzeichnis

Exp Clin Endocrinol Diabetes 2020; 128(02): 119-124
DOI: 10.1055/a-0669-9333

Article

Changes in Serum Immunoglobulin G4 Levels in Patients with Newly Diagnosed Graves’ Disease

Izumi Hiratsuka

¹Department of Endocrinology & Metabolism, Fujita Health University School of Medicine 1-98 Dengakugakubo, Kutsukake-cho, Toyoake, Aichi, Japan

,

Hiroya Yamada

²Department of Hygiene, Fujita Health University School of Medicine 1-98 Dengakugakubo, Kutsukake-cho, Toyoake, Aichi, Japan

,

Mitsuyasu Itoh

¹Department of Endocrinology & Metabolism, Fujita Health University School of Medicine 1-98 Dengakugakubo, Kutsukake-cho, Toyoake, Aichi, Japan

,

Megumi Shibata

¹Department of Endocrinology & Metabolism, Fujita Health University School of Medicine 1-98 Dengakugakubo, Kutsukake-cho, Toyoake, Aichi, Japan

,

Takeshi Takayanagi

¹Department of Endocrinology & Metabolism, Fujita Health University School of Medicine 1-98 Dengakugakubo, Kutsukake-cho, Toyoake, Aichi, Japan

,

Masaki Makino

¹Department of Endocrinology & Metabolism, Fujita Health University School of Medicine 1-98 Dengakugakubo, Kutsukake-cho, Toyoake, Aichi, Japan

,

Yoshihisa Sugimura

¹Department of Endocrinology & Metabolism, Fujita Health University School of Medicine 1-98 Dengakugakubo, Kutsukake-cho, Toyoake, Aichi, Japan

,

Nobuki Hayakawa

³Clinical Pharmacotherapeutics I, Faculty of Pharmacy, Meijo University, 1-501 Shiogamaguchi, Tempaku-ku, Nagoya, Aichi, Japan

,

Shuji Hashimoto

²Department of Hygiene, Fujita Health University School of Medicine 1-98 Dengakugakubo, Kutsukake-cho, Toyoake, Aichi, Japan

,

Atsushi Suzuki

¹Department of Endocrinology & Metabolism, Fujita Health University School of Medicine 1-98 Dengakugakubo, Kutsukake-cho, Toyoake, Aichi, Japan

› Institutsangaben

Abstract

Objective Immunoglobulin G4 (IgG4)-related disease (IgG4-RD) is an immune-mediated condition that can affect almost any organ. We investigated the association between IgG4-RD and the main characteristics of Graves’ disease (GD) at the time of diagnosis. Additionally, we evaluated whether serum IgG4 levels change during treatment.

Design and patients Twenty-eight patients with newly diagnosed GD were enrolled into this longitudinal follow-up study. Serum IgG4 levels and thyroid function were measured in all the participants at the time of diagnosis. Further, the serum IgG4 levels of nine of 28 patients with untreated GD were measured after the achievement of euthyroid state (through the use of methimazole).

Results Two (7.1%) of 28 patients with untreated GD had elevated serum IgG4 levels of >135 mg/dL. There was no significant difference in the average IgG4 levels before and after the achievement of euthyroid state (66.2±74.0 mg/dL vs. 50.5±47.3 mg/dL). In two patients, the elevated serum IgG4 levels returned to normal after treatment. However, one patient had an elevated serum IgG4 level of 136.6 mg/dL after treatment.

Conclusions This study showed that serum IgG4 levels varied with treatment in patients with GD, independent of thyroid function, suggesting that IgG4 might be indirectly related to GD.

Key words

serum IgG4 level - thyroid - longitudinal study - IgG4-RD

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Referenzen

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