Sarcopenia – Endocrinological and Neurological Aspects

Michaela Katja Stangl; Wolfgang Böcker; Vladimir Chubanov; Uta Ferrari; Michael Fischereder; Thomas Gudermann; Eric Hesse; Peter Meinke; Martin Reincke; Nicole Reisch; Maximilian M. Saller; Jochen Seissler; Ralf Schmidmaier; Benedikt Schoser; Cornelia Then; Barbara Thorand; Michael Drey

doi:10.1055/a-0672-1007

Experimental and Clinical Endocrinology & Diabetes, Table of Contents

Exp Clin Endocrinol Diabetes 2019; 127(01): 8-22
DOI: 10.1055/a-0672-1007

Review

Sarcopenia – Endocrinological and Neurological Aspects

Michaela Katja Stangl

¹Department of Medicine IV, University Hospital, LMU Munich, Germany

,

Wolfgang Böcker

²Experimental Surgery and Regenerative Medicine (ExperiMed), Department of General, Trauma and Reconstructive Surgery, University Hospital, LMU Munich, Germany

,

Vladimir Chubanov

³Walther Straub Institute of Pharmacology and Toxicology, Faculty of Medicine, LMU Munich, Germany

,

Uta Ferrari

¹Department of Medicine IV, University Hospital, LMU Munich, Germany

,

Michael Fischereder

⁴Department of General, Visceral and Transplantation Surgery, University Hospital, LMU Munich, Germany

,

Thomas Gudermann

³Walther Straub Institute of Pharmacology and Toxicology, Faculty of Medicine, LMU Munich, Germany

,

Eric Hesse

⁵Heisenberg-Group for Molecular Skeletal Biology, Department of Trauma, Hand and Reconstructive Surgery, University Medical Centre Hamburg-Eppendorf, Hamburg, Germany

,

Peter Meinke

⁶Friedrich Baur Institute at the Department of Neurology, University Hospital, LMU Munich, Germany

,

Martin Reincke

¹Department of Medicine IV, University Hospital, LMU Munich, Germany

,

Nicole Reisch

¹Department of Medicine IV, University Hospital, LMU Munich, Germany

,

Maximilian M. Saller

²Experimental Surgery and Regenerative Medicine (ExperiMed), Department of General, Trauma and Reconstructive Surgery, University Hospital, LMU Munich, Germany

,

Jochen Seissler

¹Department of Medicine IV, University Hospital, LMU Munich, Germany

,

Ralf Schmidmaier

¹Department of Medicine IV, University Hospital, LMU Munich, Germany

,

Benedikt Schoser

⁶Friedrich Baur Institute at the Department of Neurology, University Hospital, LMU Munich, Germany

,

Cornelia Then

¹Department of Medicine IV, University Hospital, LMU Munich, Germany

,

Barbara Thorand

⁷Institute of Epidemiology, Helmholtz Center Munich, German Research Center for Environmental Health, Munich, Germany

,

Michael Drey

¹Department of Medicine IV, University Hospital, LMU Munich, Germany

› Author Affiliations

Abstract

Sarcopenia in geriatric patients is often associated with or even caused by changes of the endocrine and nervous system. The multifactorial pathogenesis of sarcopenia and additional multimorbidity in geriatric patients makes it difficult to study distinct pathogenic pathways leading to sarcopenia. Patients suffering from diabetes, Cushing’s syndrome, chronic kidney disease, Klinefelter’s syndrome or motor neuron diseases, such as amyotrophic lateral sclerosis for example are known to have impaired muscle property and reduced physical performance. These patients are typically younger and suffer from conditions caused by a known molecular disease mechanism and a peculiar sarcopenic phenotype. Therefore, these sequelae can serve as prototypic disease models to study isolated endocrinological and neurodegenerative causes for sarcopenia. This review focuses on diseases whose etiopathogenesis of muscle impairment is known. The idea is to use these diseases as proof of principles to develop a classification algorithm of sarcopenia in the elderly to make a more mechanism-oriented therapy be possible.

Key words

sarcopenia - pathomechanisms - muscle - hormones - diabetes - neurodegeneration

Full Text

References

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