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CC BY-NC-ND 4.0 · Geburtshilfe Frauenheilkd 2018; 78(10): 949-971
DOI: 10.1055/a-0713-1218
GebFra Science
Guideline/Leitlinie
Georg Thieme Verlag KG Stuttgart · New York

Interdisciplinary Diagnosis, Therapy and Follow-up of Patients with Endometrial Cancer. Guideline (S3-Level, AWMF Registry Nummer 032/034-OL, April 2018) – Part 1 with Recommendations on the Epidemiology, Screening, Diagnosis and Hereditary Factors of Endometrial Cancer

Article in several languages: English | deutsch
Günter Emons
1   Klinik für Gynäkologie und Geburtshilfe, Universitätsmedizin Göttingen, Göttingen, Germany
,
Eric Steiner
2   Frauenklinik, GPR Klinikum Rüsselsheim am Main, Rüsselsheim, Germany
,
Dirk Vordermark
3   Radiotherapy, Universität Halle/Saale, Halle/Saale, Germany
,
Christoph Uleer
4   Facharzt für Frauenheilkunde und Geburtshilfe, Hildesheim, Hildesheim, Germany
,
Nina Bock
1   Klinik für Gynäkologie und Geburtshilfe, Universitätsmedizin Göttingen, Göttingen, Germany
,
Kerstin Paradies
5   Konferenz Onkologischer Kranken- und Kinderkrankenpflege, Hamburg, Germany
,
Olaf Ortmann
6   Frauenheilkunde und Geburtshilfe, Universität Regensburg, Regensburg, Germany
,
Stefan Aretz
7   Institut für Humangenetik, Universität Bonn, Zentrum für erbliche Tumorerkrankungen, Universitätsklinikum Bonn, Bonn, Germany
,
Peter Mallmann
8   Frauenheilkunde, Uniklinik Köln, Köln, Germany
,
Christian Kurzeder
9   Frauenklinik, Universitätsspital Basel, Basel, Switzerland
,
Volker Hagen
10   Klinik für Innere Medizin II, St.-Johannes-Hospital Dortmund, Dortmund, Germany
,
Birgitt van Oorschot
11   Interdisziplinäres Zentrum Palliativmedizin, Universitätsklinikum Würzburg, Würzburg, Germany
,
Stefan Höcht
12   Xcare, Praxis für Strahlentherapie, Saarlouis, Saarlouis, Germany
,
Petra Feyer
13   Klinik für Strahlentherapie und Radioonkologie, Vivantes Klinikum Neukölln, Berlin, Germany
,
Gerlinde Egerer
14   Zentrum für Innere Medizin, Universitätsklinikum Heidelberg, Heidelberg, Germany
,
Michael Friedrich
15   Frauenklinik, HELIOS-Klinikum Krefeld, Krefeld, Germany
,
Wolfgang Cremer
16   Praxis für Frauenheilkunde Hamburg, Hamburg, Germany
,
Franz-Josef Prott
17   Facharzt für Radiologie und Strahlentherapie, Wiesbaden, Germany
,
Lars-Christian Horn
18   Institut für Pathologie, Universitätsklinikum Leipzig, Leipzig, Germany
,
Heinrich Prömpeler
19   Klinik für Frauenheilkunde, Universitätsklinikum Freiburg, Freiburg, Germany
,
Jan Langrehr
20   Klinik für Allgemein-, Gefäß- und Viszeralchirurgie, Martin-Luther-Krankenhaus, Berlin, Germany
,
Steffen Leinung†
21   Muldentalkliniken, Grimma, Germany
,
Matthias W. Beckmann
22   Dept. of OB/Gyn, University Hospital Erlangen, Erlangen, Germany
,
Rainer Kimmig
23   Womenʼs Department, University Hospital of Essen, Essen, Germany
,
Anne Letsch
24   Medizinische Klinik mit Schwerpunkt Hämatologie und Onkologie, Charité, Campus Benjamin Franklin, Universitätsmedizin Berlin, Berlin, Germany
,
Michael Reinhardt
25   Klinik für Nuklearmedizin, Pius Hospital Oldenburg, Oldenburg, Germany
,
Bernd Alt-Epping
26   Klinik für Palliativmedizin, Universitätsmedizin Göttingen, Göttingen, Germany
,
Ludwig Kiesel
27   Obstetrics and Gynecology, Reproductive Medicine, University of Muenster, Germany, Münster, Germany
,
Jan Menke
28   Institut für Diagnostische und Interventionelle Radiologie, Universitätsmedizin Göttingen, Göttingen, Germany
,
Marion Gebhardt
29   Frauenselbsthilfe nach Krebs e. V., Erlangen, Erlangen/Forchheim, Germany
,
Verena Steinke-Lange
30   MGZ – Medizinisch Genetisches Zentrum, München und Medizinische Klinik und Poliklinik IV, Campus Innenstadt, Klinikum der Universität München, München, Germany
,
Nils Rahner
31   Institut für Humangenetik, Universitätsklinikum Düsseldorf, Düsseldorf, Germany
,
Werner Lichtenegger
32   Frauenklinik Charité, Campus Virchow-Klinikum, Universitätsmedizin Berlin, Berlin, Germany
,
Alain Zeimet
33   Frauenheilkunde, Medizinische Universität Innsbruck, Innsbruck, Austria
,
Volker Hanf
34   Frauenklinik Nathanstift – Klinikum Fürth, Fürth, Germany
,
Joachim Weis
35   Stiftungsprofessur Selbsthilfeforschung, Tumorzentrum/CCC Freiburg, Universitätsklinikum Freiburg, Freiburg, Germany
,
Michael Mueller
36   Universitätsklinik für Frauenheilkunde, Inselspital Bern, Bern, Switzerland
,
Ulla Henscher
37   Praxis für Physiotherapie, Hannover, Germany
,
Rita K. Schmutzler
38   Center for Familial Breast and Ovarian Cancer, University Hospital of Cologne, Cologne, Germany
,
Alfons Meindl
39   Frauenklinik am Klinikum rechts der Isar, München, Germany
,
Felix Hilpert
40   Mammazentrum, Krankenhaus Jerusalem, Hamburg, Germany
,
Joan Elisabeth Panke
41   Medizinischer Dienst des Spitzenverbandes Bund der Krankenkassen e. V., Essen, Germany
,
Vratislav Strnad
42   Strahlenklinik, Universitätsklinikum Erlangen, CCC ER-EMN, Universitäts-Brustzentrum Franken, Erlangen, Germany
,
Christiane Niehues
43   Deutsche Rentenversicherung Bund, Berlin, Germany
,
Timm Dauelsberg
44   Winkelwaldklinik Nordrach, Fachklinik für onkologische Rehabilitation, Nordrach, Germany
,
Peter Niehoff
45   Strahlenklinik, Sana Klinikum Offenbach, Offenbach, Germany
,
Doris Mayr
46   Pathologisches Institut, LMU München, München, Germany
,
Dieter Grab
47   Frauenklinik Klinikum Harlaching, München, Germany
,
Michael Kreißl
48   Universitätsklinik für Radiologie und Nuklearmedizin, Universitätsklinikum Magdeburg, Magdeburg, Germany
,
Ralf Witteler
27   Obstetrics and Gynecology, Reproductive Medicine, University of Muenster, Germany, Münster, Germany
,
Annemarie Schorsch
49   Frauenselbsthilfe nach Krebs e. V., Bad Soden, Germany
,
Alexander Mustea
50   Universitätsmedizin Greifswald, Greifswald, Germany
,
Edgar Petru
51   Frauenheilkunde, Medizinische Universität Graz, Graz, Austria
,
Jutta Hübner
52   Klinikum für Innere Medizin II, Universitätsklinikum Jena, Jena, Germany
,
Anne Derke Rose
43   Deutsche Rentenversicherung Bund, Berlin, Germany
,
Edward Wight
53   Frauenklinik des Universitätsspitals Basel, Basel, Switzerland
,
Reina Tholen
54   Deutscher Verband für Physiotherapie, Referat Bildung und Wissenschaft, Köln, Germany
,
Gerd J. Bauerschmitz
1   Klinik für Gynäkologie und Geburtshilfe, Universitätsmedizin Göttingen, Göttingen, Germany
,
Markus Fleisch
55   Landesfrauenklinik, HELIOS Universitätsklinikum Wuppertal, Wuppertal, Germany
,
Ingolf Juhasz-Boess
56   Klinik für Frauenheilkunde, Geburtshilfe und Reproduktionsmedizin, Universitätsklinikum des Saarlandes und Medizinische Fakultät der Universität des Saarlandes, Homburg, Saar, Germany
,
Lax Sigurd
57   Institut für Pathologie, Landeskrankenhaus Graz West, Graz, Austria
,
Ingo Runnebaum
58   Frauenklinik, Universitätsklinikum Jena, Jena, Germany
,
Clemens Tempfer
59   Marien Hospital Herne – Universitätsklinikum der Ruhr-Universität Bochum, Herne, Germany
,
Monika J. Nothacker
60   AWMF-IMWi, AWMF, Berlin, Germany
,
Susanne Blödt
60   AWMF-IMWi, AWMF, Berlin, Germany
,
Markus Follmann
61   Deutsche Krebsgesellschaft, Office des Leitlinienprogramms Onkologie, Berlin, Germany
,
Thomas Langer
61   Deutsche Krebsgesellschaft, Office des Leitlinienprogramms Onkologie, Berlin, Germany
,
Heike Raatz
62   Institut für Klinische Epidemiologie & Biostatistik (CEB), Basel, Switzerland
,
Simone Wesselmann
63   Deutsche Krebsgesellschaft e. V., Berlin, Germany
,
Saskia Erdogan
1   Klinik für Gynäkologie und Geburtshilfe, Universitätsmedizin Göttingen, Göttingen, Germany
› Author Affiliations
Further Information

Publication History

received 21 August 2018

accepted 22 August 2018

Publication Date:
19 October 2018 (online)

Also available at
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Abstract

Summary The first German interdisciplinary S3-guideline on the diagnosis, therapy and follow-up of patients with endometrial cancer was published in April 2018. Funded by German Cancer Aid as part of an Oncology Guidelines Program, the lead coordinators of the guideline were the German Society of Gynecology and Obstetrics (DGGG) and the Gynecological Oncology Working Group (AGO) of the German Cancer Society (DKG).

Purpose The use of evidence-based, risk-adapted therapy to treat low-risk women with endometrial cancer avoids unnecessarily radical surgery and non-useful adjuvant radiotherapy and/or chemotherapy. This can significantly reduce therapy-induced morbidity and improve the patientʼs quality of life as well as avoiding unnecessary costs. For women with endometrial cancer and a high risk of recurrence, the guideline defines the optimal surgical radicality together with the appropriate chemotherapy and/or adjuvant radiotherapy where required. The evidence-based optimal use of different therapeutic modalities should improve survival rates and the quality of life of these patients. The S3-guideline on endometrial cancer is intended as a basis for certified gynecological cancer centers. The aim is that the quality indicators established in this guideline will be incorporated in the certification processes of these centers.

Methods The guideline was compiled in accordance with the requirements for S3-level guidelines. This includes, in the first instance, the adaptation of source guidelines selected using the DELBI instrument for appraising guidelines. Other consulted sources include reviews of evidence which were compiled from literature selected during systematic searches of literature databases using the PICO scheme. In addition, an external biostatistics institute was commissioned to carry out a systematic search and assessment of the literature for one area of the guideline. The identified materials were used by the interdisciplinary working groups to develop suggestions for Recommendations and Statements, which were then modified during structured consensus conferences and/or additionally amended online using the DELPHI method with consent being reached online. The guideline report is freely available online.

Recommendations Part 1 of this short version of the guideline presents recommendations on epidemiology, screening, diagnosis and hereditary factors, The epidemiology of endometrial cancer and the risk factors for developing endomentrial cancer are presented. The options for screening and the methods used to diagnose endometrial cancer including the pathology of the cancer are outlined. Recommendations are given for the prevention, diagnosis, and therapy of hereditary forms of endometrial cancer.

Key words

endometrial cancer - epidemiology - genetics - guideline - screening - hereditary factors
 

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