Update Breast Cancer 2018 (Part 3) – Genomics, Individualized Medicine and Immune Therapies – in the Middle of a New Era: Prevention and Treatment Strategies for Early Breast Cancer

Achim Wöckel; Michael P. Lux; Wolfgang Janni; Andreas D. Hartkopf; Naiba Nabieva; Florin-Andrei Taran; Friedrich Overkamp; Peyman Hadji; Hans Tesch; Johannes Ettl; Diana Lüftner; Volkmar Müller; Manfred Welslau; Erik Belleville; Sara Y. Brucker; Florian Schütz; Peter A. Fasching; Tanja N. Fehm; Andreas Schneeweiss; Hans-Christian Kolberg

doi:10.1055/a-0715-2821

Geburtshilfe und Frauenheilkunde, Table of Contents

CC BY-NC-ND 4.0 · Geburtshilfe Frauenheilkd 2018; 78(11): 1110-1118
DOI: 10.1055/a-0715-2821

GebFra Science

Review/Übersicht

Georg Thieme Verlag KG Stuttgart · New York

Update Mammakarzinom 2018 (Teil 3) – Genomforschung, individualisierte Medizin und Immuntherapien – mitten in einer neuen Ära: Prävention und Therapie des frühen Mammakarzinoms

Article in several languages: English | deutsch

Authors

Achim Wöckel

¹Department of Gynecology and Obstetrics, University Hospital Würzburg, Germany
Michael P. Lux

²Erlangen University Hospital, Department of Gynecology and Obstetrics, Comprehensive Cancer Center Erlangen-EMN, Friedrich-Alexander University Erlangen-Nuremberg, Erlangen, Germany
Wolfgang Janni

³Department of Gynecology and Obstetrics, Ulm University Hospital, Ulm, Germany
Andreas D. Hartkopf

⁴Department of Obstetrics and Gynecology, University of Tübingen, Tübingen, Germany
Naiba Nabieva

²Erlangen University Hospital, Department of Gynecology and Obstetrics, Comprehensive Cancer Center Erlangen-EMN, Friedrich-Alexander University Erlangen-Nuremberg, Erlangen, Germany
Florin-Andrei Taran

⁴Department of Obstetrics and Gynecology, University of Tübingen, Tübingen, Germany
Friedrich Overkamp

⁵OncoConsult Hamburg GmbH, Hamburg, Germany
Peyman Hadji

⁶Department of Bone Oncology, Nordwest Hospital, Frankfurt, Germany
Hans Tesch

⁷Oncology Practice at Bethanien Hospital Frankfurt, Frankfurt, Germany
Johannes Ettl

⁸Department of Obstetrics and Gynecology, Klinikum rechts der Isar, Technical University of Munich, Munich, Germany
Diana Lüftner

⁹Charité University Hospital, Berlin, Campus Benjamin Franklin, Department of Hematology, Oncology and Tumour Immunology, Berlin, Germany
Volkmar Müller

¹⁰Department of Gynecology, Hamburg-Eppendorf University Medical Center, Hamburg, Germany
Manfred Welslau

¹¹Onkologie Aschaffenburg, Hämatolo-Onkologische Schwerpunktpraxis am Klinikum Aschaffenburg, Aschaffenburg, Germany
Erik Belleville

¹²ClinSol GmbH & Co KG, Würzburg, Germany
Sara Y. Brucker

⁴Department of Obstetrics and Gynecology, University of Tübingen, Tübingen, Germany
Florian Schütz

¹³Department of Obstetrics and Gynecology, University of Heidelberg, Heidelberg, Germany
Peter A. Fasching

²Erlangen University Hospital, Department of Gynecology and Obstetrics, Comprehensive Cancer Center Erlangen-EMN, Friedrich-Alexander University Erlangen-Nuremberg, Erlangen, Germany
Tanja N. Fehm

¹⁴Department of Gynecology and Obstetrics, University Hospital Düsseldorf, Düsseldorf, Germany
Andreas Schneeweiss

¹³Department of Obstetrics and Gynecology, University of Heidelberg, Heidelberg, Germany

¹⁵National Center for Tumor Diseases, Division Gynecologic Oncology, University Hospital Heidelberg, Heidelberg, Germany
Hans-Christian Kolberg

¹⁶Department of Gynecology and Obstetrics, Marienhospital Bottrop, Bottrop, Germany

Abstract

Zusammenfassung

Beim primären, frühen Mammakarzinom zielt die Behandlungsplanung auf ein immer besseres Verständnis der Erkrankung ab. Die Identifikation von Patientinnen mit einer exzellenten Prognose könnte dieser Gruppe helfen, unnötige Therapien zu vermeiden. Weiterhin wird die Planung der Therapie immer weiter auf die Patientin abgestimmt. Das Wissen über Patientinnen, die besonders von einer Chemotherapie profitieren, wächst genauso wie das Wissen um Patientinnen, die von einer Immuntherapie profitieren könnten. Hinsichtlich der Immuntherapien stehen die durchgeführten Studien kurz vor der Publikation. Einzelne kleinere Studien bieten einen ersten Einblick in die Wirksamkeit der Checkpoint-Inhibitoren (Anti-PD1/PDL1-Therapien). Nicht zuletzt konnte kürzlich eine der größten Brustkrebsstudien aller Zeiten zu Ende geführt werden. Die Anwendung eines Multigentests konnte zeigen, dass er ausreicht, um Patientinnen mit einer so guten Prognose zu identifizieren, dass keine Chemotherapie nötig ist. Dieser Review-Artikel soll die aktuellen Studien zusammenfassen und einen Ausblick der gegenwärtigen Entwicklungen geben.

Schlüsselwörter

Mammakarzinom - Behandlung - Metastasen - CDK4/6, PD1/PDL1, Studien - Risiko - Prävention

Full Text

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