Update Breast Cancer 2018 (Part 4) – Genomics, Individualized Medicine and Immune Therapies – in the Middle of a New Era: Treatment Strategies for Advanced Breast Cancer

Volkmar Müller; Achim Wöckel; Michael P. Lux; Wolfgang Janni; Andreas D. Hartkopf; Naiba Nabieva; Florin-Andrei Taran; Peyman Hadji; Hans Tesch; Johannes Ettl; Diana Lüftner; Manfred Welslau; Erik Belleville; Sara Y. Brucker; Florian Schütz; Peter A. Fasching; Tanja N. Fehm; Hans-Christian Kolberg; Andreas Schneeweiss; Friedrich Overkamp

doi:10.1055/a-0715-2899

Geburtshilfe und Frauenheilkunde, Table of Contents

CC BY-NC-ND 4.0 · Geburtshilfe Frauenheilkd 2018; 78(11): 1119-1128
DOI: 10.1055/a-0715-2899

GebFra Science

Review/Übersicht

Georg Thieme Verlag KG Stuttgart · New York

Update Mammakarzinom 2018 (Teil 4) – Genomforschung, individualisierte Medizin und Immuntherapien – mitten in einer neuen Ära: Therapie des fortgeschrittenen Mammakarzinoms

Article in several languages: English | deutsch

Volkmar Müller

¹Department of Gynecology, Hamburg-Eppendorf University Medical Center, Hamburg, Germany

,

Achim Wöckel

²Department of Gynecology and Obstetrics, University Hospital Würzburg, Germany

,

Michael P. Lux

³Erlangen University Hospital, Department of Gynecology and Obstetrics, Comprehensive Cancer Center Erlangen-EMN, Friedrich-Alexander University Erlangen-Nuremberg, Erlangen, Germany

,

Wolfgang Janni

⁴Department of Gynecology and Obstetrics, Ulm University Hospital, Ulm, Germany

,

Andreas D. Hartkopf

⁵Department of Obstetrics and Gynecology, University of Tübingen, Tübingen, Germany

,

Naiba Nabieva

³Erlangen University Hospital, Department of Gynecology and Obstetrics, Comprehensive Cancer Center Erlangen-EMN, Friedrich-Alexander University Erlangen-Nuremberg, Erlangen, Germany

,

Florin-Andrei Taran

⁵Department of Obstetrics and Gynecology, University of Tübingen, Tübingen, Germany

,

Peyman Hadji

⁶Department of Bone Oncology, Nordwest Hospital, Frankfurt, Germany

,

Hans Tesch

⁷Oncology Practice at Bethanien Hospital Frankfurt, Frankfurt, Germany

,

Johannes Ettl

⁸Department of Obstetrics and Gynecology, Klinikum rechts der Isar, Technical University of Munich, Munich, Germany

,

Diana Lüftner

⁹Charité University Hospital, Berlin, Campus Benjamin Franklin, Department of Hematology, Oncology and Tumour Immunology, Berlin, Germany

,

Manfred Welslau

¹⁰Onkologie Aschaffenburg, Hämatolo-Onkologische Schwerpunktpraxis am Klinikum Aschaffenburg, Aschaffenburg, Germany

,

Erik Belleville

¹¹ClinSol GmbH & Co. KG, Würzburg, Germany

,

Sara Y. Brucker

⁵Department of Obstetrics and Gynecology, University of Tübingen, Tübingen, Germany

,

Florian Schütz

¹²Department of Obstetrics and Gynecology, University of Heidelberg, Heidelberg, Germany

,

Peter A. Fasching

³Erlangen University Hospital, Department of Gynecology and Obstetrics, Comprehensive Cancer Center Erlangen-EMN, Friedrich-Alexander University Erlangen-Nuremberg, Erlangen, Germany

,

Tanja N. Fehm

¹³Department of Gynecology and Obstetrics, University Hospital Düsseldorf, Düsseldorf, Germany

,

Hans-Christian Kolberg

¹⁴Department of Gynecology and Obstetrics, Marienhospital Bottrop, Bottrop, Germany

,

Andreas Schneeweiss

¹²Department of Obstetrics and Gynecology, University of Heidelberg, Heidelberg, Germany

¹⁵National Center for Tumor Diseases, Division Gynecologic Oncology, University Hospital Heidelberg, Heidelberg, Germany

,

Friedrich Overkamp

¹⁶OncoConsult Hamburg GmbH, Hamburg, Germany

› Author Affiliations

Abstract

Zusammenfassung

Neue Therapieentwicklungen zur Behandlung von Patientinnen mit fortgeschrittenem Mammakarzinom konzentrieren sich zurzeit sowohl auf die Identifikation von Patientinnen für zielgerichtete Therapieansätze als auch auf die Weiterentwicklung von immuntherapeutischen Ansätzen. Die Datenlage zu den CDK4/6-Inhibitoren konnte vervollständigt werden und ist konsistent in dieser Klasse von Substanzen (Palbociclib, Ribociclib und Abemaciclib). Weitere Signalwege, die untersucht werden, sind der PI3K-und der AKT-Signalweg sowie verschiedene Ansatzpunkte zu deren Hemmung. Für beide Wirkmechanismen liegen auch erste Studienergebnisse vor, die vor Kurzem vorgestellt wurden. Außerdem wachsen die Erkenntnisse zu den PARP-Inhibitoren, für die auch untersucht wird, in welcher Population sie am effektivsten eingesetzt werden können. Dieser Review-Artikel soll die aktuellen Studien zusammenfassen und einen Ausblick der neuesten Entwicklungen geben.

Schlüsselwörter

Mammakarzinom - Behandlung - Metastasen - CDK4/6 - PD1/PDL1

Full Text

References

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