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Planta Med 2019; 85(02): 154-159
DOI: 10.1055/a-0733-7229
Natural Product Chemistry and Analytical Studies
Original Papers
Georg Thieme Verlag KG Stuttgart · New York

New Cytotoxic Cycloartane Triterpenes from the Aerial Parts of Actaea heracleifolia (syn. Cimicifuga heracleifolia)

Qiang-Qiang Shi   *
1   State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Science, Kunming, China
2   University of the Chinese Academy of Science, Beijing, China
3   Yunnan Key Laboratory of Natural Medicinal Chemistry Chinese Academy of Sciences, Kunming, China
,
Wei-Hua Wang   *
1   State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Science, Kunming, China
2   University of the Chinese Academy of Science, Beijing, China
3   Yunnan Key Laboratory of Natural Medicinal Chemistry Chinese Academy of Sciences, Kunming, China
,
Jing Lu
1   State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Science, Kunming, China
2   University of the Chinese Academy of Science, Beijing, China
3   Yunnan Key Laboratory of Natural Medicinal Chemistry Chinese Academy of Sciences, Kunming, China
,
Da-Shan Li
1   State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Science, Kunming, China
3   Yunnan Key Laboratory of Natural Medicinal Chemistry Chinese Academy of Sciences, Kunming, China
,
Lin Zhou
1   State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Science, Kunming, China
3   Yunnan Key Laboratory of Natural Medicinal Chemistry Chinese Academy of Sciences, Kunming, China
,
Ming-Hua Qiu
1   State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Science, Kunming, China
3   Yunnan Key Laboratory of Natural Medicinal Chemistry Chinese Academy of Sciences, Kunming, China
› Author Affiliations
Further Information

Publication History

received 25 June 2018
revised 21 August 2018

accepted 28 August 2018

Publication Date:
19 September 2018 (online)

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Abstract

One new 15,16-seco-cycloartane triterpene (1), three new cycloartane triterpene glycosides (2–4), and five known compounds (5–9) were isolated from the aerial parts of Actaea heracleifolia. The chemical structures of these compounds were determined on the basis of NMR analysis, HRTOF-ESIMS data, and other spectroscopic methods. Selected compounds were evaluated for their cytotoxicity against human tumor cell lines (HL-60, SMMC-7721, A549, MCF-7, and SW480) in vitro. Compounds 3 and 4 showed weak activity against the HL-60, A-549, and MCF-7 cell lines with IC50 values ranging from 21.34 to 36.98 µM.

Key words

Actaea heracleifolia - Ranunculaceae - 15,16-seco-cycloartane triterpene - cycloartane triterpene glycosides - cytotoxicity - NMR

* These authors contributed equally to the work reported in this article.


Supporting Information

    The NMR, IR, UV, and HRTOF-ESIMS spectra of compounds 1–5, as well as the dose-response curves of cytotoxic activity, are available as Supporting Information.

  • Supporting Information
 

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