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Exp Clin Endocrinol Diabetes 2021; 129(02): 77-85
DOI: 10.1055/a-0741-6937
Review

Clinical Characteristics of Patients with co-Existent Diabetic Peripheral Neuropathy and Depression: A Systematic Review

Maria Zafeiri
1   Diabetes and Obesity Center, Konstantopouleio Hospital, Nea Ionia, Athens, Greece
2   Society of Junior Doctors, Athens, Greece
,
Constantinos Tsioutis
2   Society of Junior Doctors, Athens, Greece
3   School of Medicine, European University Cyprus, Nicosia, Cyprus
,
Zoe Kleinaki
2   Society of Junior Doctors, Athens, Greece
3   School of Medicine, European University Cyprus, Nicosia, Cyprus
,
Philip Manolopoulos
2   Society of Junior Doctors, Athens, Greece
3   School of Medicine, European University Cyprus, Nicosia, Cyprus
,
Ioannis Ioannidis
1   Diabetes and Obesity Center, Konstantopouleio Hospital, Nea Ionia, Athens, Greece
4   1st Department of Internal Medicine, Konstantopouleio Hospital, Nea Ionia, Athens, Greece
,
George Dimitriadis
5   2nd Department of Internal Medicine, Research Institute and Diabetes Centre, National and Kapodistrian University of Athens, Attikon University Hospital, Haidari, Athens, Greece
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Abstract

Objectives Both diabetic peripheral neuropathy and depression have significant implications on patients’ quality of life, management and outcomes. We aimed to evaluate all available evidence concerning patients with co-existent diabetic peripheral neuropathy and depression, and describe their clinical characteristics, in order to promote early recognition and management.

Methods Systematic search of PubMed for studies providing data on patients with diabetic peripheral neuropathy and depression. The primary outcome was to evaluate all available evidence related to characteristics of diabetes, diabetic peripheral neuropathy and depression. Secondary study outcomes included comorbid conditions and complications in these patients.

Results Final analysis included 24 studies with data on 205 patients. Most patients were adults between 18–65 years of age. Mean HbA1c value was above 8% and most patients were treated with insulin. Neuropathy was predominantly painful and most patients with available data were considered to have major depressive disorder. In addition to diabetic peripheral neuropathy and depression, diabetes-related complications were recorded in 43 patients, the most common being autonomic neuropathy, retinopathy and nephropathy. The most frequently reported comorbidities were weight loss (72 patients), impotence (60 patients), hypertension (23 patients) and coronary artery disease (22 patients).

Conclusions The present study describes the characteristics of patients with co-existent diabetic peripheral neuropathy and depression, aiming for prompt detection, prevention of further deterioration and improvement of patient outcomes. Available evidence shows that the majority of these patients are adults, with painful peripheral neuropathy and with insulin-treated and inadequately controlled diabetes.

Key words

diabetes mellitus - diabetic peripheral neuropathy - depression - complications


Publication History

Received: 28 July 2018
Received: 24 August 2018

Accepted: 13 September 2018

Article published online:
26 September 2018

© 2021. Thieme. All rights reserved.

Georg Thieme Verlag KG
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