Pharmakotherapie der therapieresistenten Schizophrenie

Viele schizophrene Patienten sprechen auf die Behandlung mit dem ersten Antipsychotikum nicht an, selbst bei adäquater Therapie. Oft sind mehrere Therapieversuche nötig, um die Symptomatik genügend zu verbessern. Je nach Ausgangslage und Zielsymptomatik (Positiv- oder Negativsymptomatik, depressive Symptome) erreicht man ein optimales Behandlungsergebnis über verschiedene Behandlungsstrategien, z. B. Dosiserhöhung, Kombination oder Augmentation.

Schlüsselwörter

Schizophrenie - Therapieresistenz - Pharmakotherapie - Clozapin

• Literatur

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