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Exp Clin Endocrinol Diabetes 2020; 128(08): 556-562
DOI: 10.1055/a-0801-8730
Article

Reduced Fat Oxidation During Exercise in Post-Menopausal Overweight-Obese Women with Higher Lipid Accumulation Product Index

Elana Stein
1   Graduate Program in Nutrition Sciences, Laboratory of Cellular and Molecular Immunology, Federal University of Health Sciences of Porto Alegre Porto Alegre, RS, Brazil
,
Igor Martins Silva
2   Graduate Program in Health Sciences, Laboratory of Cellular and Molecular Immunology, Federal University of Health Sciences of Porto Alegre, Porto Alegre, RS, Brazil
,
Gilson P. Dorneles
2   Graduate Program in Health Sciences, Laboratory of Cellular and Molecular Immunology, Federal University of Health Sciences of Porto Alegre, Porto Alegre, RS, Brazil
,
Fabio Santos Lira
5   Exercise and Immunometabolism Research Group, Post-Graduation Program in Movement Sciences, Department of Physical Education, State University of São Paulo – UNESP. School of Technology and Sciences, Presidente Prudente, Sao Paulo, Brazil
,
Pedro Romão
2   Graduate Program in Health Sciences, Laboratory of Cellular and Molecular Immunology, Federal University of Health Sciences of Porto Alegre, Porto Alegre, RS, Brazil
,
Alessandra Peres
1   Graduate Program in Nutrition Sciences, Laboratory of Cellular and Molecular Immunology, Federal University of Health Sciences of Porto Alegre Porto Alegre, RS, Brazil
3   Graduate Program in Rehabilitation Sciences, Laboratory of Cellular and Molecular Immunology, Federal University of Health Sciences of Porto Alegre, Porto Alegre, RS, Brazil
4   Research Center, Graduate Program in Bioscience and Rehabilitation, Methodist University Center IPA, Porto Alegre, RS, Brazil
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Abstract

Background and Aims The main aim of this study was to analyze how the lipid accumulation affects the whole-body fat oxidation over a range of intensities during a submaximal incremental exercise test in post-menopausal overweight-obese women.

Patients and Methods The maximal fat oxidation (MFO), the intensity where the MFO occurs (FatMax), fat oxidation were measured over a range of intensities during a submaximal incremental exercise test through indirect calorimetry in 60 postmenopausal overweight-obese women (aged>49 years; body mass index 28.0 to 39.0 kg/m²). The metabolic profile of participants was evaluated and the LAP index was calculated (waist-58×triglycerides [mmol/L]). A cutoff point of 34.5 was adopted and participant were designed as low LAP index (n=30) or high LAP index (n=30).

Results During submaximal exercise postmenopausal overweight-obese women with low LAP index showed a higher fat oxidation at 50% (0.53±0.05 vs. 0.45±0.12 g/min; p=0.01), 60% (0.40±0.06 vs. 0.31±0.16 g/min; p=0.02) and 70% (0.34±0.08 vs. 0.25±0.15 g/min; p=0.03) of VO2Peak than those with high LAP index. No significant difference was observed in carbohydrate oxidation between groups (p>0.05) during exercise. Moreover, a significant difference in absolute MFO (p=0.018), MFO relative to free fat mass (p=0.043) and FatMax (p=0.002) was identified.

Conclusion Postmenopausal overweight-obese women who showed unhealthy metabolic phenotype evaluated through LAP index presented low fat oxidation during a submaximal incremental exercise.

Key words

fatmax - lipid oxidation - exercise - metabolism - obesity


Publikationsverlauf

Eingereicht: 17. September 2018
Eingereicht: 09. November 2018

Angenommen: 19. November 2018

Artikel online veröffentlicht:
10. Dezember 2018

© Georg Thieme Verlag KG
Stuttgart · New York

 

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