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Geburtshilfe Frauenheilkd 2019; 79(02): 184-188
DOI: 10.1055/a-0805-9113
GebFra Science
Review/Übersicht
Georg Thieme Verlag KG Stuttgart · New York

Mechanisms of Metastasis and Cell Mobility – The Role of Metabolism

Article in several languages: English | deutsch
Carsten Gründker
Universitätsmedizin Göttingen, Klinik für Gynäkologie und Geburtshilfe, Göttingen, Germany
,
Matthias Läsche
Universitätsmedizin Göttingen, Klinik für Gynäkologie und Geburtshilfe, Göttingen, Germany
,
Johanna W. Hellinger
Universitätsmedizin Göttingen, Klinik für Gynäkologie und Geburtshilfe, Göttingen, Germany
,
Günter Emons
Universitätsmedizin Göttingen, Klinik für Gynäkologie und Geburtshilfe, Göttingen, Germany
› Author Affiliations
Further Information

Publication History

received 05 November 2018
revised 22 November 2018

accepted 23 November 2018

Publication Date:
18 February 2019 (online)

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Abstract

Tumour metastasis is responsible for more than 90% of tumour-associated mortality. About one third of breast cancer patients in the early stage develop metastases. The transformation in tumour development referred to as the “metastatic cascade” or “metastatic cycle” is a complex and multi-stage event. While it is generally recognised that epithelial-mesenchymal transformation (EMT) plays a crucial role in cancer progression and metastasis, the metabolic events in this process have received little attention to date. We would therefore like to provide a brief overview here of the influence of the metabolism on the progression and metastasis of tumours.

Key words

breast cancer - metastasis - metabolism - aerobic glycolysis
 

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