Future Aspects of Clinical Osteoarthritis Therapies in the Continuum of Translational Research

Steffen Schrenker; Liang Gao; Magali Cucchiarini; Henning Madry

doi:10.1055/a-0806-8225

Zeitschrift für Orthopädie und Unfallchirurgie, Table of Contents

Z Orthop Unfall 2019; 157(06): 629-643
DOI: 10.1055/a-0806-8225

Review/Übersicht

Georg Thieme Verlag KG Stuttgart · New York

Zukunftsaspekte der klinischen Arthrosetherapie im Kontinuum der translationalen Forschung

Article in several languages: English | deutsch

Steffen Schrenker

¹Lehrstuhl für Experimentelle Orthopädie und Arthroseforschung, Universitätsklinikum des Saarlandes und Medizinische Fakultät der Universität des Saarlandes, Homburg

,

Liang Gao

¹Lehrstuhl für Experimentelle Orthopädie und Arthroseforschung, Universitätsklinikum des Saarlandes und Medizinische Fakultät der Universität des Saarlandes, Homburg

,

Magali Cucchiarini

¹Lehrstuhl für Experimentelle Orthopädie und Arthroseforschung, Universitätsklinikum des Saarlandes und Medizinische Fakultät der Universität des Saarlandes, Homburg

,

Henning Madry

¹Lehrstuhl für Experimentelle Orthopädie und Arthroseforschung, Universitätsklinikum des Saarlandes und Medizinische Fakultät der Universität des Saarlandes, Homburg

²Zentrum für Experimentelle Orthopädie, Universitätsklinikum des Saarlandes, Homburg

› Author Affiliations

Abstract

Zusammenfassung

Die Arthrose betrifft eine signifikante Anzahl der erwachsenen Weltbevölkerung. Da in den letzten Jahren verschiedene kausale Ansätze zur klinischen Arthrosetherapie auf der Basis neuer translationaler Erkenntnisse entwickelt wurden, gibt dieser Artikel zunächst einen kurzen Überblick über neue Erkenntnisse zur Pathophysiologie und Genetik der Arthrose sowie das Zusammenspiel zwischen Biomechanik, Schmerz und Körpergewicht. Die Datenlage aktueller Studien zu pharmakologischen und rekonstruktiv-chirurgischen sowie zu regenerativen und molekularen Therapien der Arthrose wie bspw. durch NGF, FGF-18, TNF-α, Wnt-Signalweg-Inhibitoren und TGF-β1-Gentransfer wird diskutiert. Grundlage dieser narrativen Übersichtsarbeit ist eine selektive Literaturrecherche in PubMed, ScienceDirect und Google Scholar.

Schlüsselwörter

Arthrose - Knie - klinische Studien - translationale Studien - selektive Übersichtsarbeit

Full Text

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