Zukunftsaspekte der klinischen Arthrosetherapie im Kontinuum der translationalen Forschung

Zusammenfassung

Die Arthrose betrifft eine signifikante Anzahl der erwachsenen Weltbevölkerung. Da in den letzten Jahren verschiedene kausale Ansätze zur klinischen Arthrosetherapie auf der Basis neuer translationaler Erkenntnisse entwickelt wurden, gibt dieser Artikel zunächst einen kurzen Überblick über neue Erkenntnisse zur Pathophysiologie und Genetik der Arthrose sowie das Zusammenspiel zwischen Biomechanik, Schmerz und Körpergewicht. Die Datenlage aktueller Studien zu pharmakologischen und rekonstruktiv-chirurgischen sowie zu regenerativen und molekularen Therapien der Arthrose wie bspw. durch NGF, FGF-18, TNF-α, Wnt-Signalweg-Inhibitoren und TGF-β1-Gentransfer wird diskutiert. Grundlage dieser narrativen Übersichtsarbeit ist eine selektive Literaturrecherche in PubMed, ScienceDirect und Google Scholar.

Schlüsselwörter

Arthrose - Knie - klinische Studien - translationale Studien - selektive Übersichtsarbeit

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