AINS - Anästhesiologie · Intensivmedizin · Notfallmedizin · Schmerztherapie, Table of Contents Anästhesiol Intensivmed Notfallmed Schmerzther 2019; 54(01): 8-9DOI: 10.1055/a-0808-1194 Topthema Einführung Georg Thieme Verlag KG Stuttgart · New York Sepsis – weiter eine große Herausforderung! Gernot Marx Recommend Article Abstract Buy Article Full Text References Literatur 1 Stevenson EK, Rubenstein AR, Radin GT. et al.. Two decades of mortality trends among patients with severe sepsis: a comparative meta-analysis. Crit Care Med 2014; 42: 625-631 doi:10.1097/CCM.0000000000000026 2 Engel C, Brunkhorst FM, Bone HG. et al.. Epidemiology of sepsis in Germany: results from a national prospective multicenter study. Intensive Care Med 2007; 33: 606-618 doi:10.1007/s00134-006-0517-7 3 SepNet Critical Care Trials Group. Incidence of severe sepsis and septic shock in German intensive care units: the prospective, multicentre INSEP study. Intensive Care Med 2016; 42: 1980-1989 doi:10.1007/s00134-016-4504-3 4 Deisz R, Rademacher S, Gilger K. et al.. Additional telemedicine rounds are a successful performance improvement strategy for sepsis management – an observational multicentre study. J Med Internet Res 2018; [in press] 5 Brenner T, Decker SO, Grumaz S. et al.. Next-generation sequencing diagnostics of bacteremia in sepsis (Next GeneSiS-Trial): Study protocol of a prospective, observational, noninterventional, multicenter, clinical trial. Medicine (Baltimore) 2018; 97: e9868 doi:10.1097/MD.0000000000009868