Late Neutrophil Priming Following a Single Session of High-intensity Interval Exercise

Vinícius de Oliveira Ottone; Karine Beatriz Costa; Rosalina Tossige-Gomes; Mariana Aguiar de Matos; Gustavo Brito-Melo; Flavio de Castro Magalhaes; Elizabethe Adriana Esteves; Fabiano Amorim; Etel Rocha-Vieira

doi:10.1055/a-0810-8533

International Journal of Sports Medicine, Table of Contents

Int J Sports Med 2019; 40(03): 171-179
DOI: 10.1055/a-0810-8533

Physiology & Biochemistry

Late Neutrophil Priming Following a Single Session of High-intensity Interval Exercise

Vinícius de Oliveira Ottone

¹Centro Integrado de Pós-graduação e Pesquisa em Saúde (CIPq-saúde), Multicentric Graduate Program in Physiological Sciences, Universidade Federal dos Vales do Jequitinhonha e Mucuri (UFVJM), Diamantina, Brazil

,

Karine Beatriz Costa

¹Centro Integrado de Pós-graduação e Pesquisa em Saúde (CIPq-saúde), Multicentric Graduate Program in Physiological Sciences, Universidade Federal dos Vales do Jequitinhonha e Mucuri (UFVJM), Diamantina, Brazil

,

Rosalina Tossige-Gomes

¹Centro Integrado de Pós-graduação e Pesquisa em Saúde (CIPq-saúde), Multicentric Graduate Program in Physiological Sciences, Universidade Federal dos Vales do Jequitinhonha e Mucuri (UFVJM), Diamantina, Brazil

,

Mariana Aguiar de Matos

¹Centro Integrado de Pós-graduação e Pesquisa em Saúde (CIPq-saúde), Multicentric Graduate Program in Physiological Sciences, Universidade Federal dos Vales do Jequitinhonha e Mucuri (UFVJM), Diamantina, Brazil

,

Gustavo Brito-Melo

¹Centro Integrado de Pós-graduação e Pesquisa em Saúde (CIPq-saúde), Multicentric Graduate Program in Physiological Sciences, Universidade Federal dos Vales do Jequitinhonha e Mucuri (UFVJM), Diamantina, Brazil

²Dept of Pharmacy, UFVJM, Brazil

,

Flavio de Castro Magalhaes

¹Centro Integrado de Pós-graduação e Pesquisa em Saúde (CIPq-saúde), Multicentric Graduate Program in Physiological Sciences, Universidade Federal dos Vales do Jequitinhonha e Mucuri (UFVJM), Diamantina, Brazil

³Dept of Physical Education, UFVJM, Brazil

,

Elizabethe Adriana Esteves

¹Centro Integrado de Pós-graduação e Pesquisa em Saúde (CIPq-saúde), Multicentric Graduate Program in Physiological Sciences, Universidade Federal dos Vales do Jequitinhonha e Mucuri (UFVJM), Diamantina, Brazil

⁴Dept of Nutrition, UFVJM

,

Fabiano Amorim

¹Centro Integrado de Pós-graduação e Pesquisa em Saúde (CIPq-saúde), Multicentric Graduate Program in Physiological Sciences, Universidade Federal dos Vales do Jequitinhonha e Mucuri (UFVJM), Diamantina, Brazil

⁵Dept of Heatlh, Exercise & Sports Sciences, University of New Mexico, Albuquerque, USA

,

Etel Rocha-Vieira

¹Centro Integrado de Pós-graduação e Pesquisa em Saúde (CIPq-saúde), Multicentric Graduate Program in Physiological Sciences, Universidade Federal dos Vales do Jequitinhonha e Mucuri (UFVJM), Diamantina, Brazil

⁶Faculty of Medicine, UFVJM, Brazil

› Author Affiliations

Abstract

This study evaluated the effect of an acute high-intensity interval exercise (HIIE) session on the function of human neutrophils. Twelve sedentary men performed a HIIE session (8 bouts of 60 s at 90% of peak power, intercalated with 75 s of active recovery at 30 W). Neutrophils were collected before, 30 min and 24 h after the exercise session for the evaluation of phagocytic capacity, expression of phagocytic receptors, reactive oxygen species generation, and redox status. 24 h after the HIIE session, an increase was observed in both neutrophil phagocytic capacity and yeast-induced generation of reactive oxygen species, which indicates neutrophil priming in response to an acute HIIE session. Neutrophils also presented an increase in superoxide dismutase activity 24 h after the exercise. Improvement in neutrophil function was accompanied by increased serum levels of IL-8 and increased concentration of plasma lactate dehydrogenase. Our findings show a late activating effect of one HIIE session on neutrophils. We propose that priming of neutrophils by HIIE may play a role in skeletal muscle inflammation after exercise.

Key words

phagocytosis - superoxide dismutase - reactive oxygen species - inflammation

Full Text

References

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