Magnetic Resonance-Guided High-Intensity Focused Ultrasound (MR-HIFU): Technical Background and Overview of Current Clinical Applications (Part 1)

Florian Siedek; Sin Yuin Yeo; Edwin Heijman; Olga Grinstein; Grischa Bratke; Carola Heneweer; Michael Puesken; Thorsten Persigehl; David Maintz; Holger Grüll

doi:10.1055/a-0817-5645

RöFo - Fortschritte auf dem Gebiet der Röntgenstrahlen und der bildgebenden Verfahren, Inhaltsverzeichnis

CC BY-NC-ND 4.0 · Rofo 2019; 191(06): 522-530
DOI: 10.1055/a-0817-5645

Review

Magnetic Resonance-Guided High-Intensity Focused Ultrasound (MR-HIFU): Technical Background and Overview of Current Clinical Applications (Part 1)

Magnetresonanz-gesteuerter hochintensiver fokussierter Ultraschall (MR-HIFU): Technische Aspekte und Überblick über die etablierten Applikationen (Teil 1)

Autoren

Florian Siedek

Institute of Diagnostic and Interventional Radiology, University Hospital of Cologne, Germany
Sin Yuin Yeo

Institute of Diagnostic and Interventional Radiology, University Hospital of Cologne, Germany
Edwin Heijman

Institute of Diagnostic and Interventional Radiology, University Hospital of Cologne, Germany
Olga Grinstein

Institute of Diagnostic and Interventional Radiology, University Hospital of Cologne, Germany
Grischa Bratke

Institute of Diagnostic and Interventional Radiology, University Hospital of Cologne, Germany
Carola Heneweer

Institute of Diagnostic and Interventional Radiology, University Hospital of Cologne, Germany
Michael Puesken

Institute of Diagnostic and Interventional Radiology, University Hospital of Cologne, Germany
Thorsten Persigehl

Institute of Diagnostic and Interventional Radiology, University Hospital of Cologne, Germany
David Maintz

Institute of Diagnostic and Interventional Radiology, University Hospital of Cologne, Germany
Holger Grüll

Institute of Diagnostic and Interventional Radiology, University Hospital of Cologne, Germany

Abstract

Background Extracorporeal high-intensity focused ultrasound (HIFU) is a promising method for the noninvasive thermal ablation of benign and malignant tissue. Current HIFU treatments are performed under ultrasound (US-HIFU) or magnetic resonance (MR-HIFU) image guidance offering integrated therapy planning, real-time control (spatial and temperature guidance) and evaluation.

Methods This review is based on publications in peer-reviewed journals addressing thermal ablation using HIFU and includes our own clinical results as well. The technical background of HIFU is explained with an emphasis on MR-HIFU applications. A brief overview of the most commonly performed CE-approved clinical applications for MR-HIFU is given.

Results Over the last decade, several HIFU-based applications have received clinical approval in various countries. In particular, MR-HIFU is now approved for the clinical treatment of uterine fibroids, palliation of bone pain, ablation of the prostate and treatment of essential tremor as a first neurological application.

Conclusion MR-HIFU is a patient-friendly noninvasive method for thermal ablation which has received clinical approval for several applications. Overall, clinical data demonstrate treatment efficacy, safety and cost efficiency.

Key Points:

HIFU is a promising technique for noninvasive thermal ablation of tissue.
HIFU is typically performed under image guidance using either diagnostic ultrasound (US-HIFU) or MRI (MR-HIFU).
The preferred image guidance modality depends on the application.
MR guidance offers improved soft-tissue contrast for treatment planning, near real-time and noninvasive temperature monitoring and post-interventional therapy evaluation.
MR-HIFU is CE-approved for treatment of uterine fibroids, alleviation of bone pain, prostate tissue ablation and treatment of essential tremor.

Citation Format

Siedek F, Yeo S, Heijman E et al. Magnetic Resonance-Guided High-Intensity Focused Ultrasound (MR-HIFU): Technical Background and Overview of Current Clinical Applications (Part 1). Fortschr Röntgenstr 2019; 191: 522 – 530

Zusammenfassung

Hintergrund Der extrakorporale hochintensive fokussierte Ultraschall (HIFU) ist ein vielversprechendes Verfahren zur nichtinvasiven Thermoablation gutartigen und bösartigen Gewebes. Derzeitige HIFU-Therapien nutzen Ultraschall (US-HIFU) oder MRT (MR-HIFU) zur Bildsteuerung mit der Möglichkeit zur integrierten Therapieplanung, Echtzeit-Therapiekontrolle (räumliche Orientierung und Temperatursteuerung) und Therapieevaluation.

Methode Dieser Übersichtsartikel basiert auf Publikationen aus Fachzeitschriften, die die thermale Ablation mittels HIFU thematisieren, und beinhaltet zudem eigene klinische Ergebnisse. Es wird ein kurzer Überblick über die häufigsten CE-zertifizierten klinischen Applikationen für MR-HIFU gegeben.

Ergebnisse Im Laufe des letzten Jahrzehnts erhielten zahlreiche HIFU-basierte Applikationen die Zulassung in diversen Ländern. Im Speziellen ist MR-HIFU nun zugelassen für die Therapie von Uterusmyomen, Linderung von Knochenschmerzen, der Ablation der Prostata und die Therapie des essenziellen Tremors als erste neurologische Applikationsform.

Schlussfolgerung MR-HIFU ist eine patientenfreundliche, nichtinvasive Methode zur Thermoablation, welche mittlerweile für mehrere klinische Applikationen zugelassen wurde. Insgesamt bestätigen die bisherigen klinischen Daten die Wirksamkeit und Sicherheit der Therapie sowie die Kosteneffizienz der Methode.

Kernaussagen:

HIFU stellt eine vielversprechende Technik zur nichtinvasiven Thermoablation von Gewebe dar.
HIFU wird üblicherweise unter Bildkontrolle mittels Ultraschall (US-HIFU) oder MRT (MR-HIFU) durchgeführt.
Die bevorzugte Bildkontrolle (US-HIFU vs. MR-HIFU) hängt von der geplanten Applikation ab.
MRT bietet einen höheren Weichteilkontrast zur Therapieplanung, eine nahezu in Echtzeit und nichtinvasiv erfolgende Temperaturkontrolle und eine postinterventionelle Therapieevaluation.
MR-HIFU ist CE-zertifiziert für die Therapie von Uterusmyomen, Linderung von Knochenschmerzen, Ablation der Prostata und Therapie des essenziellen Tremors.

Key words

HIIFU - interventional procedures - ablation procedures - hyperthermia - uterine fibroids - pain palliation

Volltext

Referenzen

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