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DOI: 10.1055/a-0828-3906
Immunonkologie beim triple-negativen Mammakarzinom
Publication History
Publication Date:
22 August 2019 (online)
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Die Rolle des Immunsystems beim Mammakarzinom rückt zunehmend in den Fokus immunonkologischer Forschungsprojekte. Insbesondere das triple-negative Mammakarzinom (TNBC) verfügt im Vergleich zu den anderen Tumorsubtypen über ein ausgeprägtes immunogenes Potenzial. Möglichkeiten einer immunonkologischen Therapie ergeben sich durch Immuncheckpoint-Inhibition, Vakzinierung oder adoptiven T-Zell-Transfer.
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TILs haben prognostische und prädiktive Bedeutung beim triple-negativen Mammakarzinom.
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Der Krebs-Immunzell-Zyklus bietet verschiedene therapeutische Angriffspunkte zur Entwicklung und Etablierung personalisierter Immuntherapien.
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Immuncheckpoint-Inhibitoren (insbesondere Atezolizumab) sind in Kombination mit Chemotherapie eine wirksame Therapieoption beim metastasierten triple-negativen Mammakarzinom, aktuell existiert in Deutschland jedoch noch keine Zulassung.
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Vakzinierung und adoptiver T-Zell-Transfer sind weitere vielversprechende immuntherapeutische Ansätze.
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