Erfahrungsheilkunde 2019; 68(01): 29-33
DOI: 10.1055/a-0828-6082
Praxis
© MVS Medizinverlage Stuttgart GmbH & Co. KG Stuttgart · New York

Jung bleiben mit Omega-3-Fettsäuren

Volker Schmiedel
Further Information

Publication History

Publication Date:
28 February 2019 (online)

Zusammenfassung

Stille Entzündung ist ein Risikofaktor für das Altern. Alle Faktoren, die dazu beitragen, Entzündungen zu reduzieren, sollten daher auch den Alterungsprozess verlangsamen können. Medikamente wie Kortison oder NSAR kommen wegen zahlreicher Nebenwirkungen allerdings nicht in Frage. Die antiinflammatorische Wirkung von Omega-3-Fettsäuren ist seit langer Zeit bekannt. Gibt es auch Nachweise, dass Altersbeschwerden wie Demenz, Sarkopenie oder Hautalterung durch Omega-3-Fettsäuren aufgehalten werden können? Der Artikel gibt eine Übersicht über die wichtigsten Studien.

Abstract

Silent inflammation is a risk factor for aging. Therefore, all factors contributing to the reduction of inflammations should also be able to slow down the aging process. However, drugs such as cortisone or NSAIDs are out of the question because of numerous side effects. The anti-inflammatory effect of omega-3 fatty acids has been known for a long time. Is there also proof, that complaints of old age such as dementia, sarcopenia or skin aging can be stopped by omega-3 fatty acids? The article provides an overview of the most important studies.

 
  • Literatur

  • 1 Bonaccio M, Di Castelnuovo A, Pounis G. et al. A score of low-grade inflammation and risk of mortality: Prospective findings from the Molisani Study. Haematologica 2016; 101 (11) 1434-1441
  • 2 Buoite Stella A, Gortan Cappellari G, Barazzoni R. et al. Update on the impact of omega 3 fatty acids on inflammation, insulin resistance and sarcopenia: A review. Int J Mol Sci 2018; 19 (01) E218 doi: 10.3390/ijms19010218
  • 3 Calder PC, Bosco N, Bourdet-Sicard R. et al. Health relevance of the modification of low grade inflammation in ageing (inflammageing) and the role of nutrition. Ageing Res Rev 2017; 40: 95-119
  • 4 Champigny CM, Cormier RPJ, Simard CJ. et al. Omega-3 monoacylglyceride effects on longevity, mitochondrial metabolism and oxidative stress: Insights from drosophila melanogaster. Mar Drugs 2018; 16 (11) E453 doi: 10.3390/md16110453
  • 5 Farzaneh-Far R, Lin J, Epel ES. et al. Association of marine omega-3 fatty acid levels with telomeric aging in patients with coronary heart disease. JAMA 2010; 303 (03) 250-257
  • 6 Green KN, Martinez-Coria H, Khashwji H. et al. Dietary docosahexaenoic acid and docosapentaenoic acid ameliorate amyloid-beta and tau pathology via a mechanism involving presenilin 1 levels. J Neurosci 2007; 27 (16) 4385-4395
  • 7 Greve SV, Blicher MK, Kruger R. et al. Elevated estimated arterial age is associated with metabolic syndrome and low-grade inflammation. J Hypertens 2016; 34 (12) 2410-2417
  • 8 Jernerén F, Elshorbagy AK, Oulhaj A. et al. Brain atrophy incognitively impaired elderly: The importance of long-chain ω-3 fatty acids and B vitamin status in a randomized controlled trial. Am J Clin Nutr 2015; 102 (01) 215-221
  • 9 Latreille J, Kesse-Guyot E, Malvy D. et al. Association between dietary intake of n-3 polyunsaturated fatty acids and severity of skin photoaging in a middle-aged Caucasian population. J Dermatol Sci 2013; 72 (03) 233-239
  • 10 Lopez LB, Kritz-Silverstein D, Barrett Connor E. High dietary and plasma levels of the omega-3 fatty acid docosahexaenoic acid are associated with decreased dementia risk: The Rancho Bernardo study. J Nutr Health Aging 2011; 15 (01) 25-31
  • 11 Osler M, Bendix L, Rask L. et al. Stressful life events and leucocyte telomere length: Do lifestyle factors, somatic and mental health, or low grade inflammation mediate this relationship? Results from a cohort of Danish men born in 1953. Brain Behav Immun 11/2016; 58: 248-253
  • 12 Oulhaj A, Jernerén F, Refsum H. et al. Omega-3 fatty acid status enhances the prevention of cognitive decline by B vitamins in mild cognitive impairment. J Alzheimers Dis 2016; 50 (02) 547-557
  • 13 Raji CA, Erickson KI, Lopez OL. et al. Regular fish consumption and age-related brain gray matter loss. Am J Prev Med 2014; 47 (04) 444-451
  • 14 Tessier AJ, Chevalier S . . An update on protein, leucine, omega-3 fatty acids, and vitamin D in the prevention and treatment of sarcopenia and functional decline. Nutrients 2018; 10 (08) E1099 doi: 10.3390/nu10081099
  • 15 Yurko-Mauro K, McCarthy D, Rom D. et al. Beneficial effects of docosahexaenoic acid on cognition in age-related cognitive decline. Alzheimers Dement 11/2010; 6 (06) 456-64 doi: 10.1016/j.jalz.2010.01.013
  • 16 Matsuoka Y, Nishi D, Yonemoto N. et al. Potential role of brain-derived neurotrophic factor in omega–3 fatty acid supplementation to prevent posttraumatic distress after accidental injury: An open-label pilot study. Psychother Psychosom 2011; 80: 310-312