Whole-Body [18F]-FDG-PET/MRI for Oncology: A Consensus Recommendation

Lale Umutlu; Thomas Beyer; Johannes Stefan Grueneisen; Christoph Rischpler; Harald H. Quick; Patrick Veit-Haibach; Matthias Eiber; Sandra Purz; Gerald Antoch; Sergios Gatidis; Konstantin Nikolaou; Jürgen F. Schaefer; Ivo Rausch; Ken Herrmann; Vorstand der Interdisziplinären AG für Hybride Bildgebung in alphabetischer Reihenfolge:; Vorstand der Deutschen Röntgengesellschaft (DRG) und der Deutschen Gesellschaft für Nuklearmedizin (DGN) in alphabetischer Reihenfolge:

doi:10.1055/a-0828-8654

RöFo - Fortschritte auf dem Gebiet der Röntgenstrahlen und der bildgebenden Verfahren, Table of Contents

Rofo 2019; 191(04): 289-297
DOI: 10.1055/a-0828-8654

Consensus

Whole-Body [18F]-FDG-PET/MRI for Oncology: A Consensus Recommendation^[*]

Konsensempfehlungen zur Anwendung der Ganzkörper [18F]-FDG-PET/MRT in der onkologischen Bildgebung

Lale Umutlu

¹Department of Diagnostic and Interventional Radiology and Neuroradiology, University-Hospital Essen, Germany

,

Thomas Beyer

²QIMP Group, Centre for Medical Imaging and Biomedical Engineering, Medical University of Vienna, Austria

,

Johannes Stefan Grueneisen

¹Department of Diagnostic and Interventional Radiology and Neuroradiology, University-Hospital Essen, Germany

,

Christoph Rischpler

³Department of Nuclear Medicine, University-Hospital Essen, Germany

,

Harald H. Quick

⁴High-Field- and Hybrid-MR-Imaging, University-Hospital Essen, Germany

,

Patrick Veit-Haibach

⁵Joint Department of Medical Imaging, University of Toronto, Canada

,

Matthias Eiber

⁶Department of Nuclear Medicine, Klinikum rechts der Isar, Technical University of Munich, Germany

,

Sandra Purz

⁷Department of Nuclear Medicine, University of Leipzig, Germany

,

Gerald Antoch

⁸Department of Diagnostic and Interventional Radiology, University Düsseldorf, Medical Faculty, Düsseldorf, Germany

,

Sergios Gatidis

⁹Department of Diagnostic and Interventional Radiology, University-Hospital Tübingen, Germany

,

Konstantin Nikolaou

⁹Department of Diagnostic and Interventional Radiology, University-Hospital Tübingen, Germany

,

Jürgen F. Schaefer

⁹Department of Diagnostic and Interventional Radiology, University-Hospital Tübingen, Germany

,

Ivo Rausch

²QIMP Group, Centre for Medical Imaging and Biomedical Engineering, Medical University of Vienna, Austria

,

Ken Herrmann

³Department of Nuclear Medicine, University-Hospital Essen, Germany

,

Vorstand der Interdisziplinären AG für Hybride Bildgebung in alphabetischer Reihenfolge:

,

Vorstand der Deutschen Röntgengesellschaft (DRG) und der Deutschen Gesellschaft für Nuklearmedizin (DGN) in alphabetischer Reihenfolge:

› Author Affiliations

Abstract

Combined PET/MR imaging (PET/MRI) was proposed for patient management in 2006 with first commercial versions of integrated whole-body systems becoming available as of 2010. PET/MRI followed the prior evolution of hybrid imaging as attested by the successful adoption of combined PET/CT and SPECT/CT since the early 2000 s. Today, around 150 whole-body PET/MRI systems have become operational worldwide. One of the main application fields of PET/MRI is oncologic imaging. Despite the increasing use of PET/MRI, little governance regarding standardized PET/MRI protocols has been provided to date. Standardization and harmonization of imaging protocols is, however, mandatory for efficient on-site patient management and multi-center studies. This document summarizes consensus recommendations on key aspects of patient referral and preparation, PET/MRI workflow and imaging protocols, as well as reporting strategies for whole-body [18F]-FDG-PET/MRI. These recommendations were created by early adopters and key experts in the field of PET, MRI and PET/MRI. This document is intended to provide guidance for the harmonization and standardization of PET/MRI today and to support wider clinical adoption of this imaging modality for the benefit of patients.

Citation Format

Umutlu L, Beyer T, Grueneisen JS et al. Whole-Body [18F]-FDG-PET/MRI for Oncology: A Consensus Recommendation. Fortschr Röntgenstr 2019; 191: 289 – 297

Zusammenfassung

Nach initialen Plänen zur Einführung integrierter PET/MRT-Systeme im Jahre 2006 standen 2010 die ersten kommerziell erwerbbaren Scanner für die klinische Anwendung am Patienten zur Verfügung. Sie folgten damit früheren, bereits etablierten hybriden Bildgebungsmodalitäten, wie der PET/CT und SPECT/CT, bei denen der Vorteil einer kombinierten Analyse molekularer und anatomischer Parameter zur Beantwortung onkologischer Fragestellungen gezeigt werden konnte. Bis dato wurden weltweit ca. 150 PET/MRT-Systeme in Kliniken, Praxen und diversen Forschungsinstitutionen installiert. Anhand der aktuellen Studienlage lässt sich die onkologische Diagnostik weiterhin als Hauptanwendungsgebiet erkennen. Aufgrund der zunehmenden Anwendung der PET/MRT in der Patientenversorgung besteht nun die Notwendigkeit einer Anpassung der Arbeitsabläufe an die Anforderungen des klinischen Alltags sowie einer Standardisierung der Untersuchungsprotokolle an die spezifischen medizinischen Fragestellungen. In dem vorliegenden Manuskript werden Konsensempfehlungen für die Indikationsstellung und Vorbereitung des Patienten sowie die Durchführung und Interpretation einer PET/MRT-Untersuchung dargestellt. Darüber hinaus werden Untersuchungsprotokolle zur Anwendung der Ganzkörper [18F]-FDG-PET/MRT zusammengefasst. Diese Empfehlungen wurden durch Experten in den Bereichen der PET, MRT und PET/MRT-Bildgebung zusammengestellt. Sie sollen zur Standardisierung der [18F]-FDG-PET/MRT-Diagnostik onkologischer Patienten und zu einer breiteren klinischen Akzeptanz dieser Bildgebungsmodalität zum Wohle der Patienten beitragen.

Key words

PET/MRI - oncology - consensus recommendations - whole-body imaging - hybrid imaging

Full Text

References

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Whole-Body [18F]-FDG-PET/MRI for Oncology: A Consensus Recommendation[*]

Whole-Body [18F]-FDG-PET/MRI for Oncology: A Consensus Recommendation^[*]