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Planta Med 2019; 85(06): 444-452
DOI: 10.1055/a-0828-9831
DOI: 10.1055/a-0828-9831
Biological and Pharmacological Activity
Original Papers
Cytotoxic Prenylated Xanthones from the Leaves of Garcinia bracteata
Weitere Informationen
Publikationsverlauf
received 28. Juni 2018
revised 23. Dezember 2018
accepted 27. Dezember 2018
Publikationsdatum:
16. Januar 2019 (online)
Abstract
Six new prenylated xanthones (1–6) and seventeen known xanthones were isolated from extracts of Garcinia bracteata leaves. Their structures were determined by extensive NMR and MS spectroscopic data analysis. The inhibitory activities of the isolates were assayed on HeLa, A549, PC-3, HT-29, and WPMY-1 cell lines. Compounds 1 and 15–17 showed moderate inhibitory effects on tumor cell growth, with IC50s ranging from 3.7 to 14.7 µM.
* These two authors contributed equally to this work.
Supporting Information
- Supporting Information I
- Supporting Information II
HRMS, UV, IR, and NMR spectra of compounds 1–6 are available as Supporting Information I, and the dose-response curves of compounds in [Table 3] are available as Supporting Information II.
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