Download PDF
Rofo 2019; 191(08): 752-753
DOI: 10.1055/a-0835-6943
The Interesting Case
© Georg Thieme Verlag KG Stuttgart · New York

Visualization of Vertebral Body Deformities in Childhood by MRI in a Boy with ALL

Xiao-Dong Zhang
1   Department of Radiology, Tianjin First Central Hospital, Nankai-University, Tianjin, Germany
,
Jawid Madjidyar
2   Department of Radiology and Neuroradiology, University-Hospital Schleswig-Holstein, Kiel, Germany
,
Sönke Peters
2   Department of Radiology and Neuroradiology, University-Hospital Schleswig-Holstein, Kiel, Germany
› Author Affiliations
Further Information

Publication History

Publication Date:
21 March 2019 (online)

Also available at
    Permissions and Reprints

Introduction

Bone marrow changes in children with acute lymphoblastic leukemia (ALL) as well as bone marrow transformation after chemotherapy is well known. Corticosteroids and methotrexate (MTX) are considered to be the main factors for the reduction of bone mineral density after chemotherapy. Therefore, reduced height of vertebral bodies due to compression fractures has been reported after chemotherapy (Alos N et al. J ClinOncol 2012; 30: 2760–2767). However, swelling of vertebral bodies at diagnosis of ALL followed by vertebral height loss after treatment has not been reported until now.