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Osteologie 2019; 28(02): 145-152
DOI: 10.1055/a-0836-0458
Originalarbeit
Georg Thieme Verlag KG Stuttgart · New York

Zusammenhang zwischen Sarkopenie und Knochendichte – eine Querschnittsuntersuchung mit Männern 72 Jahre + mit Sarkopenie

Association of Sarcopenia and Osteopenia – a crossectional study with men 72 years + with Sarcopenia
Wolfgang Kemmler
1   Institut für Medizinische Physik, Friedrich-Alexander Universität Erlangen-Nürnberg (FAU)
,
Regina Straub
1   Institut für Medizinische Physik, Friedrich-Alexander Universität Erlangen-Nürnberg (FAU)
,
Matthias Kohl
2   Fakultät Medical and Life Sciences, Fachhochschule Furtwangen
,
Simon von Stengel
1   Institut für Medizinische Physik, Friedrich-Alexander Universität Erlangen-Nürnberg (FAU)
› Author Affiliations
Further Information

Publication History

11 January 2019

17 January 2019

Publication Date:
24 May 2019 (online)

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Zusammenfassung

Ziel der Untersuchung war es, den Zusammenhang zwischen Sarkopenie und Osteoporose bei älteren Männern zu erfassen.

Selbstständig lebende Männer, 72 Jahre + mit einer morphometrischen Sarkopenie (n = 78), wurden in die Untersuchung eingeschlossen. Mittels multipler Regressionsanalyse wurde insb. der Erklärungsbeitrag der Sarkopeniekriterien wie „Handkraft“, „Gehgeschwindigkeit“ und „skelettaler Muskelmassenindex“ auf die Knochendichte (BMD) an LWS und Hüfte (tHip) untersucht. Daneben wurden Unterschiede für die BMD zwischen Sarkopenie und Prä-Sarkopenie evaluiert.

In der Analyse wurden geringe aber signifikante Erklärungsbeiträge der Größen „fettfreie Masse“ (r2 = .06, p = .001) und „Körperfettanteil“ (r2 = .04, p = .011) auf die BMD-tHip erfasst. Als finaler Parameter der Regressionsanalyse für die BMD-LWS verblieb die Gehgeschwindigkeit, die allerdings keinen relevanten Erklärungsbeitrag (r2 = .03, p = .113) liefert. Unterschiede für die BMD an LWS und Hüfte zwischen Männern mit Sarkopenie vs. Prä-Sarkopenie wurden nicht erfasst (p ≥ .95).

Für selbstständig lebende Männer 72 Jahre + mit morphometrischer (Prä-Sarkopenie) oder morphometrisch-funktioneller Sarkopenie scheint kein erhöhtes Osteoporose-Risiko zu bestehen.

Abstract

Introduction There is some evidence that due to muscle-bone interaction, Sarcopenia might be closely related to Osteopenia and Osteoporosis in older people. The objective of the present article was thus to (1) determine the association between Sarcopenia criteria and bone mineral density (BMD), (2) to determine differences in BMD between Pre-Sarcopenia and Sarcopenia and (3) to consider whether there is an increased risk of Osteopenia and Osteoporosis in community dwelling older men with Sarcopenia.

Methods Seventy-eight community dwelling men 72 years and older with Pre-Sarcopenia or Sarcopenia (39 each) according to the 2010 European Working Group on Sarcopenia in Older People (EWGSOP-I) were included in the study. Stepwise multivariate regression analysis was conducted to determine the relative contribution of sarcopenia criteria (ie. skeletal muscle mass index, handgrip-strength, habitual gait speed) on BMD of the lumbar spine (LS) and total hip (tHip) area. Further, differences in BMD-LS and tHip were compared between men with Pre-Sarcopenia and Sarcopenia. Osteopenia (–1.0 to –2.5 standard deviations (SD) T-Score) and Osteoporosis (≥ 2.5 SD T-Score) were defined according to WHO.

Results We observed a low but significant explanatory contribution of “fat free mass” (r2 = .06, p = .001) and “body fat rate” (r2 = .04, p = .011), both positively associated with the BMD of the total hip. Apart from “habitual gait speed” (r2 = .03, p = .113) no further parameters contributed to the final model of BMD-LS. Differences in BMD at the tHip or LS were not determined when comparing men with Pre-Sarcopenia versus Sarcopenia (p ≥ .95). Further, we did not observe a higher prevalence for Osteopenia or Osteoporosis in the present cohort.

Conclusion In summary, the association of parameters presently representing Sarcopenia and Osteoporosis was quite weak in this cohort. Thus, we conclude that at least in community-dwelling men 72 years and older with Sarcopenia according to the EWGSOP-I definition there is no relevantly increased risk of osteopenia and osteoporosis. However, it is doubtful whether this result can be transferred to corresponding older women or institutionalized older people.

Schlüsselwörter

Sarkopenie - Osteoporose - Knochendichte - älterer Mann - selbstständig lebend

Key words

Sarcopenia - Osteoporosis - Bone Mineral Density - older men - community dwelling
 

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