Der kausale Zusammenhang von Prostata-Hyperplasie, chronischer Prostatitis und Prostatakrebs

Zusammenfassung

Die häufigsten Erkrankungen der Prostata sind Prostatitis, die benigne Prostata-Hyperplasie (BPH) und das Prostatakarzinom (PCa). Die westliche Ernährungs- und Lebensweise führt typischerweise zu einer Vermehrung von Bauchfett, erhöhten Spiegeln von Cholesterin, Östrogenen und Dihydrotestosteron (DHT) sowie Insulin und IGF-1, welche die Entwicklung von ProstataHyperplasie und -krebs fördern. Die vergrößerte Prostata begünstigt die Entwicklung einer chronischen Prostatitis, indem sie zu Urinrückfluss in die Prostata führt. Dies wirkt sich in der peripheren Zone der Prostata am schlimmsten aus, da sie ein schlechtes Ablaufsystem hat. Der proinflammatorischste Stoff im Urin ist kristalline Harnsäure, die sich bei pH 5,5 bildet. So sauer ist bei der heute typischen säurebildenden Ernährung häufig der Morgenurin, der insbesondere nachts (Nykturie) in die Prostata gelangt. Auch die Aktivität der 5-alpha-Reduktase ist bei saurem pH stark erhöht und prokanzerogenes DHT wird verstärkt gebildet. Die chronische Prostatitis fördert insbesondere durch den dauerhaft erhöhten oxidativen und nitrosativen Stress die Entstehung eines Prostatakarzinoms in der Randzone. Klassische Kanzerogene im Urin und im Enddarm verstärken den Prozess. Epidemiologisch passt dazu, dass die typischen „Säureerkrankungen“ Gicht und Nierensteine mit einem stark erhöhten Prostatakrebsrisiko einhergehen, während pflanzliche, basenbildende Ernährungsweisen das Risiko deutlich reduzieren und in klinischen Studien sogar bestehende Karzinome hemmen.

Abstract

The most common prostate diseases are prostatitis, benign prostatic hyperplasia (BPH) and prostate cancer (PCa). Western diets and lifestyles typically lead to an increase in abdominal fat, elevated levels of cholesterol, estrogens and dihydrotestosterone (DHT), as well as insulin and IGF-1, which promote the development of prostatic hyperplasia and cancer. The enlarged prostate favors the development of chronic prostatitis by causing intraprostatic reflux. This has the worst effect in the peripheral area of the prostate, as it has a poor drainage system. The most proinflammatory substance in urine is crystalline uric acid, which forms at pH 5.5. Eating the typical acid-forming diet of today, mens’ morning urine, which enters the prostate during the night (nycturia), is this acidic. The activity of 5-alpha reductase is also greatly increased at an acidic pH and more procarcinogenic DHT is formed. Chronic prostatitis promotes the development of prostate carcinoma in the peripheral zone, in particular due to the permanently increased oxidative and nitrosative stress. Classical carcinogens in the urine and rectum intensify this process. From an epidemiological point of view, the typical “acid diseases” gout and kidney stones are associated with a strongly increased risk of prostate cancer, while plant-based, alkaline diets significantly reduce the risk and even inhibit existing carcinomas in clinical studies.

Schlüsselwörter

Prostatakrebs - Hyperplasie - BPH - Prostatitis - intraprostatischer Reflux - pH - Harnsäure - Säure-Basen-Haushalt - Ernährung - 5-alpha-Reduktase - Haarverlust - DHT - Matrix-Metalloproteinasen

Key words

Prostate cancer - hyperplasia - BPH - prostatitis - reflux - pH - uric acid - acid-base balance - diet - nutrition - 5-alpha reductase - DHT - hair loss - MMP

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