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Dtsch Med Wochenschr 2019; 144(25): 1778-1783
DOI: 10.1055/a-0869-9899
Übersicht
© Georg Thieme Verlag KG Stuttgart · New York

Maurice Raynaud (1834–1881) und das Mysterium „Raynaud-Phänomen“

Maurice Raynaud (1834–1881) and the Mystery of “Raynaud’s Phanomenon”
Ulrich Koehler
,
Irene Portig
,
Olaf Hildebrandt
,
Niklas Alexander Koehler
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Publikationsverlauf

Publikationsdatum:
17. Dezember 2019 (online)

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Abstract

Maurice Raynaud first described color changes and symptoms of the fingers due to cold-induced vasospasm and restricted blood flow in his medical school thesis in 1862. Raynaud’s phenomenon is common and exists as an uncomplicated primary Raynaud phenomenon and a Raynaud phenomenon secondary to underlying diseases and medication. Mechanisms contributing to altered vasoconstrictor activity are endothelial and not-endothelial. Cold-induced vasospasm is probably a thermoregulatory problem and effects are mediated by sympathetic activity and selective stimulation of alpha2c-adrenoreceptors.

Es ist das große Verdienst von Raynaud, dass er die klinischen Symptome und Lokalbefunde des „Raynaud-Phänomens“ nicht nur beschrieb, sondern auch versuchte, diese in einen klinischen Zusammenhang zu bringen. Anfälle der lokalen Asphyxie, das plötzliche Blasswerden der Finger und Zehen („dead finger“) sowie deren Berührungs- und Schmerzempfindlichkeit unter Kälte und Erregung: bis heute ein „Phänomen“!

Schlüsselwörter

Triggerfaktor - Hand-Arm-Vibrationstätigkeit - Reperfusionsschaden - Prostazykline - Sklerodermie

Key words

trigger factor - hand-arm vibration activity - reperfusion injury - prostacyclins - scleroderma
 

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