A Cut-off Value for Gestational Week at Birth for Better Perinatal Outcomes in Early- and Late-Onset Fetal Growth Restriction

Mehmet Sinan Beksac; Erdem Fadiloglu; Atakan Tanacan; Apostolos Mamopoulos; Merve Basol; Daniel Muresan; Apostolos Athanasiadis

doi:10.1055/a-0882-7425

Zeitschrift für Geburtshilfe und Neonatologie, Table of Contents

Z Geburtshilfe Neonatol 2019; 223(05): 289-296
DOI: 10.1055/a-0882-7425

Original Article

A Cut-off Value for Gestational Week at Birth for Better Perinatal Outcomes in Early- and Late-Onset Fetal Growth Restriction

Mehmet Sinan Beksac

¹Department of Obstetrics and Gynecology, Division of Perinatal Medicine, Hacettepe University, Ankara, Turkey

,

Erdem Fadiloglu

¹Department of Obstetrics and Gynecology, Division of Perinatal Medicine, Hacettepe University, Ankara, Turkey

,

Atakan Tanacan

¹Department of Obstetrics and Gynecology, Division of Perinatal Medicine, Hacettepe University, Ankara, Turkey

,

Apostolos Mamopoulos

²Department of Obstetrics and Gynecology, Aristotle University of Thessaloniki School of Medicine, Thessaloniki, Greece

,

Merve Basol

³Department of Biostatistics, Hacettepe University, Ankara, Turkey

,

Daniel Muresan

⁴Department of Obstetrics and Gynecology, Universitatea de Medicina si Farmacie Iuliu Hatieganu, Cluj-Napoca, Romania

,

Apostolos Athanasiadis

²Department of Obstetrics and Gynecology, Aristotle University of Thessaloniki School of Medicine, Thessaloniki, Greece

› Author Affiliations

Abstract

Objective Prediction of cut-off value for gestational week at birth for better perinatal outcomes in early- and late-onset fetal growth restriction (FGR).

Materials and Methods This study consists of 83 singleton pregnancies with FGR that were diagnosed antenatally and confirmed postnatally between January 2017–April 2018. We used the 34^th gestational week as a cut-off for early- and late-onset FGR discrimination.

Results Early- and late-onset FGRs were detected in 22 (26.5%) and 61 (73.5%) of the cases, respectively. Expectant management significantly improved birth weight and Apgar scores at the 1^st, 5^th, and 10^th minute in early-onset FGR cases (p=0.001, p=0.019, p=0.002, and p=0.001,respectively). Similar analysis revealed no significant improvements in late-onset FGR (p=0.151, p=0.727, p=0.951 and p=0.477, respectively). Umbilical cord blood gas pH was found to be similar between management modalities in both the early- and late-onset groups (p=0.186 and p=0.456, respectively). Gestational week 33.5 was found to be the threshold for better Apgar scores at the 1^st, 5^th, and 10^th minute according to ROC curve analysis. Percentiles of 4.5, 2.5, and 4.5 were cut-off values for better Apgar scores at the 1^st, 5^th, and 10^th minute, respectively.

Conclusion Expectant management must be the first choice to improve Apgar scores in early-onset FGR cases, and gestational week 33.5 must be considered as a threshold for delivery. Immediate delivery might be the choice in late-onset FGR in necessary cases. However, etiology-based management and perinatal surveillance might also be considered to improve prematurity-related neonatal complications.

Key words

pregnancy - high risk pregnancy - management - IUGR

Full Text

References

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