Altered Brain Regional Homogeneity in First-Degree Relatives of Type
                    2 Diabetics: A functional MRI Study

Yiyong Liu; Lin Shi; Xiubao Song; Changzheng Shi; Wutao Lou; Dong Zhang; Alan D. Wang; Liangping Luo

doi:10.1055/a-0883-4955

Experimental and Clinical Endocrinology & Diabetes, Inhaltsverzeichnis

Exp Clin Endocrinol Diabetes 2020; 128(11): 737-744
DOI: 10.1055/a-0883-4955

Article

Altered Brain Regional Homogeneity in First-Degree Relatives of Type 2 Diabetics: A functional MRI Study

Autoren

Yiyong Liu

¹Medical Imaging Center, the First Affiliated Hospital of Jinan University, Guangzhou, China
Lin Shi

³Department of Imaging and Interventional Radiology, Research Centre for Medical Image Computing, The Chinese University of Hong Kong, China

⁴Chow Yuk Ho Technology Centre for Innovative Medicine, The Chinese University of Hong Kong, China
Xiubao Song

²Department of Rehabilitation, the First Affiliated Hospital of Jinan University, Guangzhou, China
Changzheng Shi

¹Medical Imaging Center, the First Affiliated Hospital of Jinan University, Guangzhou, China
Wutao Lou

³Department of Imaging and Interventional Radiology, Research Centre for Medical Image Computing, The Chinese University of Hong Kong, China
Dong Zhang

¹Medical Imaging Center, the First Affiliated Hospital of Jinan University, Guangzhou, China
Alan D. Wang

⁵Auckland Bioengineering Institute, and Faculty of Medical and Health Sciences, University of Auckland, Auckland, New Zealand

⁶Shenzhen SmartView MedTech Limited, Shenzhen, China
Liangping Luo

¹Medical Imaging Center, the First Affiliated Hospital of Jinan University, Guangzhou, China

Abstract

Objective This study aimed to investigate regional homogeneity in the first-degree relatives of type 2 diabetes patients.

Methods Seventy-eight subjects, including 26 type 2 diabetes patients, 26 first-degree relatives, and 26 healthy controls, were assessed. All participants underwent resting-state functional magnetic resonance imaging scanning. The estimated regional homogeneity value was used to evaluate differences in brain activities.

Results In first-degree relatives, we observed significantly decreased regional homogeneity in the left anterior cingulate cortex, left insula, and bilateral temporal lobes, and increased regional homogeneity in the left superior frontal gyrus, right anterior cingulate cortex, and bilateral posterior cingulate cortex compared to healthy controls. In type 2 diabetes patients, we detected altered regional homogeneity in the left anterior cingulate cortex, left insula, bilateral posterior cingulate cortex, and several other brain regions compared to healthy controls. Both first-degree relatives and type 2 diabetes patients showed decreased regional homogeneity in the left superior temporal gyrus, right middle temporal gyrus, left anterior cingulate cortex, left insula, and increased regional homogeneity in the left superior frontal gyrus and bilateral posterior cingulate cortex.

Conclusion These findings suggest that altered regional homogeneity in the left anterior cingulate cortex, left insula, left superior frontal gyrus, bilateral posterior cingulate cortex, and bilateral temporal lobes might be a neuroimaging biomarker of type 2 diabetes -related brain dysfunction.

Key words

first-degree relatives - type 2 diabetes - cognitive performance - resting-state functional magnetic resonance imaging - regional homogeneity

Volltext

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