Lipid Profiles in Lyme Borreliosis: A Potential Role for Apheresis?

Richard Straube; Karin Voit-Bak; A. Gor; Til Steinmeier; George P. Chrousos; Bernhard Otto Boehm; Andreas L. Birkenfeld; Mahmoud Barbir; Wladimir Balanzew; Stefan R. Bornstein

doi:10.1055/a-0885-7169

Hormone and Metabolic Research, Table of Contents

Horm Metab Res 2019; 51(05): 326-329
DOI: 10.1055/a-0885-7169

Endocrine Care

Lipid Profiles in Lyme Borreliosis: A Potential Role for Apheresis?

Richard Straube

¹Zentrums für Apherese- und Hämofiltration am INUS Tagesklinikum, Cham, Germany

,

Karin Voit-Bak

¹Zentrums für Apherese- und Hämofiltration am INUS Tagesklinikum, Cham, Germany

,

A. Gor

¹Zentrums für Apherese- und Hämofiltration am INUS Tagesklinikum, Cham, Germany

,

Til Steinmeier

¹Zentrums für Apherese- und Hämofiltration am INUS Tagesklinikum, Cham, Germany

,

George P. Chrousos

²First Department of Pediatrics, Medical School, Division of Endocrinology, Diabetes and Metabolism, National and Kapodistrian University of Athens, “Aghia Sophia” Children's Hospital, Athens, Greece

,

Bernhard Otto Boehm

³Lee Kong Chian School of Medicine, NTU Nanyang Technological University, Singapore, Singapore

,

Andreas L. Birkenfeld

⁴Department of Medicine III, Section of Metabolic and Vascular Medicine, University Hospital Carl Gustav Carus, Dresden, Germany

⁵Division of Diabetes & Nutritional Sciences, Faculty of Life Sciences & Medicine, King's College London, London, UK

⁶Paul Langerhans Institute Dresden of the Helmholtz Center Munich at University Hospital and Faculty of Medicine, TU Dresden, Dresden, Germany

⁷German Center for Diabetes Research (DZD e.V.), Neuherberg, Germany

,

Mahmoud Barbir

⁸Royal Brompton & Harefield NHS Foundation Trust, Lipoprotein-Apheresis Unit, Cardiology Department, Harefield Hospital, Harefield, Middlesex, UK

,

Wladimir Balanzew

⁹Department of Medicine III, University Hospital Carl Gustav Carus, Dresden, Germany

,

Stefan R. Bornstein

³Lee Kong Chian School of Medicine, NTU Nanyang Technological University, Singapore, Singapore

⁵Division of Diabetes & Nutritional Sciences, Faculty of Life Sciences & Medicine, King's College London, London, UK

⁶Paul Langerhans Institute Dresden of the Helmholtz Center Munich at University Hospital and Faculty of Medicine, TU Dresden, Dresden, Germany

⁷German Center for Diabetes Research (DZD e.V.), Neuherberg, Germany

⁹Department of Medicine III, University Hospital Carl Gustav Carus, Dresden, Germany

¹⁰Klinik für Endokrinologie, Diabetologie und Klinische Ernährung, University Hospital, Zürich, Switzerland

› Author Affiliations

Abstract

Dyslipidemia and dyslipoproteinemia are common causes of metabolic and cardiovascular diseases. On the other hand, intracellular bacteria, such as Borrelia burgdorferi, utilize host lipids to survive and disseminate within the host. Recent data suggest that elevated lipids are a contributing factor to the maintenance and severity of Lyme disease and its complications. Here we review and discuss the role of lipids in Borreliosis and report on a pilot trial to examine the potential roles of circulating lipids and lipoproteins in patients with Borrelia infection. In this analysis we assessed the clinical and lipid profiles of 519 patients (319 women, 200 men) with a proven history of Lyme disease, before and after an extracorporeal double membrane filtration. Lipid profiles pre- and post-apheresis were analyzed in conjunction with clinical symptoms and parameters of inflammation. Circulating cholesterol, triglycerides, LDL, LP(a), and other inflammatory lipids were significantly reduced after the apheresis, while symptoms of the disorder and bioindexes of inflammation such as CRP improved. Further studies should be initiated to investigate the possibly causal relation between Lyme disease and circulating lipids and to design appropriate therapeutic strategies.

Key words

lipidapheresis - borreliosis - inflammation

Full Text

References

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