Pathophysiologie des kardiorenalen Syndroms

Severin Schricker; Martin Kimmel

doi:10.1055/a-0886-1340

Dialyse aktuell, Table of Contents

Dialyse aktuell 2019; 23(05): 208-213
DOI: 10.1055/a-0886-1340

Schwerpunkt | Nephrologie

Pathophysiologie des kardiorenalen Syndroms

Eine aktuelle Übersicht

Severin Schricker

Allgemeine Innere Medizin und Nephrologie, Robert-Bosch-Krankenhaus, Stuttgart

,

Martin Kimmel

Allgemeine Innere Medizin und Nephrologie, Robert-Bosch-Krankenhaus, Stuttgart

› Author Affiliations

Abstract

ZUSAMMENFASSUNG

Das kardiorenale Syndrom beschreibt die bidirektionale Interaktion zwischen Herz- und Nierenerkrankungen. Eine akute oder chronische Dysfunktion sowohl des Herzens als auch der Nieren kann eine Dysfunktion des jeweils anderen Organs verursachen. Pathophysiologisch spielen bei der akuten Schädigung v. a. hämodynamische Veränderungen und insbesondere die Rechtsherzinsuffizienz (Rückwärtsversagen) mit renal- venöser Stauung und Abnahme des transglomerulären Gradienten eine Rolle. In der Chronifizierung gewinnen v. a. die Hypervolämie und, vermittelt über die neurohormonelle Aktivierung der Renin-Angiotensin-Aldosteron-Achse, die glomeruläre und myokardiale Sklerosierung an Bedeutung.

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References

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