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CC BY-NC-ND 4.0 · Geburtshilfe Frauenheilkd 2019; 79(06): 605-617
DOI: 10.1055/a-0887-0285
GebFra Science
Review/Übersicht
Georg Thieme Verlag KG Stuttgart · New York

Diagnosis and Therapy of Triple-Negative Breast Cancer (TNBC) – Recommendations for Daily Routine Practice

Artikel in mehreren Sprachen: English | deutsch
Andreas Schneeweiss
1   Nationales Centrum für Tumorerkrankungen (NCT), Universitätsklinikum, Heidelberg, Germany
2   Deutsches Krebsforschungszentrum, Heidelberg, Germany
,
Carsten Denkert
3   Institut für Pathologie, Universitätsklinikum Gießen und Marburg GmbH, Standort Marburg, Philipps-Universität Marburg, Marburg, Germany
,
Peter A. Fasching
4   Frauenklinik des Universitätsklinikums Erlangen, Comprehensive Cancer Center Erlangen-EMN, Friedrich-Alexander Universität Erlangen-Nürnberg, Erlangen, Germany
,
Carlo Fremd
1   Nationales Centrum für Tumorerkrankungen (NCT), Universitätsklinikum, Heidelberg, Germany
,
Oleg Gluz
5   Brustzentrum Niederrhein, Evangelisches Krankenhaus Bethesda, Mönchengladbach, Germany
6   Westdeutsche Studiengruppe, Mönchengladbach, Germany
,
Cornelia Kolberg-Liedtke
7   Charité – Universitätsmedizin Berlin, Campus Mitte, Berlin, Germany
,
Sibylle Loibl
8   German Breast Group c/o GBG Forschungs GmbH, Neu-Isenburg, Germany
9   Zentrum für Hämatologie und Onkologie Bethanien, Goethe Universität Frankfurt, Frankfurt am Main, Germany
,
Hans-Joachim Lück
10   Gynäkologie Onkologie, Gynäkologisch-onkologische Praxis, Hannover, Germany
› Institutsangaben
Weitere Informationen

Publikationsverlauf

received 23. Januar 2019
revised 29. März 2019

accepted 01. April 2019

Publikationsdatum:
14. Juni 2019 (online)

Auch verfügbar auf
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Abstract

The rapid increase in knowledge in tumour biology and tumour pathogenesis of triple-negative breast cancer (TNBC) has resulted in new therapeutic approaches and new therapeutic concepts for treatment. For years, TNBC has been considered to be a difficult-to-treat tumour due to its generally aggressive tumour biology and in view of limited therapeutic options. The risk of recurrence and metastasis is higher than in the case of other breast cancer subtypes of the same stage. In addition to surgery and radiation in the curative situation, systemic chemotherapy with anthracyclines and/or taxanes is still the therapy of choice. New therapeutic approaches are based on the knowledge that TNBC is a molecularly very heterogeneous disease. Research groups are working to classify TNBC better and better on a molecular level and use this molecular subtyping as the basis for new therapeutic strategies. The most promising new approaches and considerations regarding the therapy of TNBCs are shown below. In addition, the current therapeutic strategies are discussed using a fictitious case history, taking the current data and the resultant therapeutic consequence into account.

Key words

triple-negative breast cancer - BRCA mutation - subtyping of TNBC - diagnosis and therapy of TNBC
 

  • References/Literatur

  • 1 Zeichner SB, Ambros T, Zaravinos J. et al. Defining the survival benchmark for breast cancer patients with systemic relapse. Breast Cancer (Auckl) 2015; 9: 9-17
    PubMedSuche in Google Scholar
  • 2 Zeichner SB, Herna S, Mani A. et al. Survival of patients with de-novo metastatic breast cancer: analysis of data from a large breast cancer-specific private practise, a university-based cancer center and review of the literature. Breast Cancer Res Treat 2015; 153: 617-624
    CrossrefPubMedSuche in Google Scholar
  • 3 Arbeitsgemeinschaft Gynäkologische Onkologie (AGO) Kommission ‚Mamma‘ (vertreten durch Wolfgang Janni). Diagnose und Behandlung von Patienten mit primärem und metastasiertem Mammakarzinom. Version 2019 v1. München: W. Zuckschwerdt; 2019. Online: www.ago-online.de last access: 27.03.2019
    Suche in Google Scholar
  • 4 Mersin H, Yildirim E, Berberoglu U. et al. The prognostic importance of triple negative breast carcinoma. Breast 2008; 17: 341-346
    CrossrefPubMedSuche in Google Scholar
  • 5 Dawood S, Lei X, Litton JK. et al. Incidence of brain metastases as a first site of recurrence among women with triple negative breast cancer. Cancer 2012; 118: 4652-4659
    CrossrefPubMedSuche in Google Scholar
  • 6 Lin NU, Vanderplas A, Hughes ME. et al. Clinicopathologic features, patterns of recurrence, and survival among women with triple negative breast cancer in the National Comprehensive cancer Network. Cancer 2012; 118: 5463
    CrossrefPubMedSuche in Google Scholar
  • 7 Leitlinienprogramm Onkologie (Deutsche Krebsgesellschaft, Deutsche Krebshilfe, AWMF). Interdisziplinäre S3-Leitlinie für die Früherkennung, Diagnostik, Therapie und Nachsorge des Mammakarzinoms, Langversion 4.0. Dezember 2017. AWMF Registernummer: 032-045OL. Online: http://www.leitlinienprogramm-onkologie.de/leitlinien/mammakarzinom/ last access: 08.10.2018
    PubMed
  • 8 Wöckel A, Festl J, Stüber T. et al. Interdisciplinary Screening, Diagnosis, Therapy and Follow-up of Breast Cancer. Guideline of the DGGG and the DKG (S3-Level, AWMF Registry Number 032/045OL, December 2017) – Part 1 with Recommendations for the Screening, Diagnosis and Therapy of Breast Cancer. Geburtsh Frauenheilk 2018; 78: 927-948
    Thieme ConnectPubMedSuche in Google Scholar
  • 9 Häberle L, Hein A, Rübner M. et al. Predicting Triple-Negative Breast Cancer Subtype Using Multiple Single Nucleotide Polymorphisms for Breast Cancer Risk and Several Variable Selection Methods. Geburtsh Frauenheilk 2017; 77: 667-678
    Thieme ConnectPubMedSuche in Google Scholar
  • 10 Stevens KN, Fredericksen Z, Vachon CM. et al. 19p13.1 is a triple-negative-specific breast cancer susceptibility locus. Cancer Res 2012; 72: 1795-1803
    CrossrefPubMedSuche in Google Scholar
  • 11 Purrington KS, Slager S, Eccles D. et al. Genome-wide association study identifies 25 known breast cancer susceptibility loci as risk factors for triple-negative breast cancer. Carcinogenesis 2012; 35: 1012-1019
    PubMedSuche in Google Scholar
  • 12 Lehmann BD, Bauer JA, Chen X. et al. Identification of human triple-negative breast cancer subtypes and preclinical models for selection of targeted therapies. J Clin Invest 2011; 121: 2750-2767
    CrossrefPubMedSuche in Google Scholar
  • 13 Lehmann BC, Jovanovic B, Chen X. et al. Refinement of Triple-Negative Breast Cancer Molecular Subtypes: Implications for Neoadjuvant Chemotherapy Selection. PLoS One 2016; 11: e0157368 doi:10.13717/journal.pone.0157368
    CrossrefPubMedSuche in Google Scholar
  • 14 Kreike B, van Kouwenhove M, Horlings H. et al. Gene expression profiling and histopathological characterization of triple-negative/basal-like breast carcinomas. Breast Cancer Res 2007; 9: R65
    CrossrefPubMedSuche in Google Scholar
  • 15 Burstein MD, Tsimelzon A, Poage GM. et al. Comprehensive genomic analysis identifies novel subtypes and targets of triple-negative breast cancer. Clin Cancer Res 2015; 21: 1688-1698
    CrossrefPubMedSuche in Google Scholar
  • 16 Jézéquel P, Loussouarn D, Guérin-Charbonnel C. et al. Gene-expression molecular subtyping of triple-negative breast cancer tumours. Importance of immune response. Breast Cancer Res 2015; 17: 43
    CrossrefPubMedSuche in Google Scholar
  • 17 Liedtke C, Mazouni C, Hess KR. et al. Response to neoadjuvant therapy and long-term survival in patients with triple-negative breast cancer. J Clin Oncol 2008; 26: 1275-1281
    CrossrefPubMedSuche in Google Scholar
  • 18 Schneeweiss A, Jackisch C, Schmatloch S. et al. Survival analysis of the prospectively randomized phase III GeparSepto trial comparing neoadjuvant chemotherapy with weekly nab-paclitaxel with solvent-based paclitaxel followed by anthracycline/cyclophosphamide for patients with early breast cancer – GBG 69. SABCS 2017; Abstr. GS3-05.
    PubMed
  • 19 Cortazar P, Zhang L, Untch M. et al. Pathological complete response and long-term clinical benefit in breast cancer: the CTNeoBC pooled analysis. Lancet 2014; 384: 164-172
    CrossrefPubMedSuche in Google Scholar
  • 20 Marty B, Maire V, Gravier E. et al. Frequent PTEN genomic alterations and activated phosphatidylinositol 3-kinase pathway in basal-like breast cancer cells. Breast Cancer Res 2008; 10: R101
    CrossrefPubMedSuche in Google Scholar
  • 21 Schmid P, Abraham J, Chan S. et al. AZD5363 plus paclitaxel versus placebo plus paclitaxel as first-line therapy for metastatic triple-negative breast cancer (PAKT): A randomised, double-blind, placebo-controlled, phase II trial. J Clin Oncol 2018; 36 (no.15_suppl): 1007-1007 doi:10.1200/JCO.2018.36.15_suppl.1007
    CrossrefPubMedSuche in Google Scholar
  • 22 Dent R, Im SA, Espie M. et al. Overall survival update of the double-blind placebo-controlled randomised phase 2 LOTUS trial of first-line Ipataserib + paclitaxel for locally advanced/metastatic triple-negative breast cancer. J Clin Oncol 2018; 36 (no.15_suppl): 1008 doi:10.1200/JCO.2018.36.15_suppl.1008
    CrossrefPubMedSuche in Google Scholar
  • 23 Harrison H, Farnie G, Howell SJ. et al. Regulation of breast cancer stem cell activity by signaling through the Notch4 receptor. Cancer Res 2010; 70: 709-718
    CrossrefPubMedSuche in Google Scholar
  • 24 Stoeck A, Lejnine S, Truong A. et al. Discovery of biomarkers predictive of GSI response in triple-negative breast cancer and adenoid cystic carcinoma. Cancer Discov 2014; 4: 1154-1167
    CrossrefPubMedSuche in Google Scholar
  • 25 Balko JM, Giltnane JM, Wang K. et al. Molecular profiling of the residual disease of triple-negative breast cancers after neoadjuvant chemotherapy identifies actionable therapeutic targets. Cancer Discov 2014; 4: 232-245
    CrossrefPubMedSuche in Google Scholar
  • 26 Baselga J, Gomez P, Greil R. et al. Randomized phase II study of the anti-epidermal growth factor receptor monoclonal antibody cetuximab with cisplatin versus cisplatin alone in patients with metastatic triple-negative breast cancer. J Clin Oncol 2013; 31: 2586-2592
    CrossrefPubMedSuche in Google Scholar
  • 27 Carey LA, Rugo HS, Marcom PK. et al. TBCRC 001: randomized phase II study of cetuximab in combination with carboplatin in stage IV triple-negative breast cancer. J Clin Oncol 2012; 30: 2615-2623
    CrossrefPubMedSuche in Google Scholar
  • 28 Brufsky A, Valero V, Tiango B. et al. Second-line bevacizumab-containing therapy in patients with triple-negative breast cancer: subgroup analysis of the RIBBON-2 trial. Breast Cancer Res Treat 2012; 133: 1067-1075
    CrossrefPubMedSuche in Google Scholar
  • 29 Turner N, Lambros MB, Horlings HM. et al. Integrative molecular profiling of triple negative breast cancers identifies amplicon drivers and potential therapeutic targets. Oncogene 2010; 29: 2013-2023
    CrossrefPubMedSuche in Google Scholar
  • 30 Sharpe R, Pearson A, Herrera-Abreu MT. et al. FGFR signaling promotes the growth of triple-negative and basal-like breast cancer cell lines both in vitro and in vivo. Clin Cancer Res 2011; 17: 5275-5286
    CrossrefPubMedSuche in Google Scholar
  • 31 Niemeier LA, Dabbs DJ, Beriwal S. et al. Androgen receptor in breast cancer: expression in estrogen receptor-positive tumors and in estrogen receptor-negative tumors with apocrine differentiation. Mod Pathol 2010; 23: 205-212
    PubMedSuche in Google Scholar
  • 32 Traina TA, Miller K, Yardley DA. et al. Enzalutamide for the Treatment of Androgen Receptor-Expressing Triple-Negative Breast Cancer. J Clin Oncol 2018; 36: 884-890
    CrossrefPubMedSuche in Google Scholar
  • 33 Yamaoka M, Hara T, Hitaka T. et al. Orteronel (TAK-700), a novel non-steroidal 17,20-lyase inhibitor: effects on steroid synthesis in human and monkey adrenal cells and serum steroid levels in cynomolgus monkeys. J Steroid Biochem Mol Biol 2012; 129: 115-128
    CrossrefPubMedSuche in Google Scholar
  • 34 Stepan LP, Trueblood ES, Hale K. et al. Expression of Trop2 cell surface glycoprotein in normal and tumor tissues: potential implications as a cancer therapeutic target. J Histochem Cytochem 2011; 59: 701-710
    CrossrefPubMedSuche in Google Scholar
  • 35 Ambrogi F, Fornili M, Boracchi P. et al. Trop2 is a determinant of breast cancer survival. PLoS One 2014; 9: e96993
    CrossrefPubMedSuche in Google Scholar
  • 36 Bardia A, Starodub A, Moroose RL. et al. IMMUN-132, a new antibody-drug-conjugate against Trop2, as a novel therapeutic for patients with relapsed/refractory, metastatic, triple-negative breast cancer: results from phase I/II clinical trial (NCT01631552). 37th San Antonio Breast Cancer Symposium (SABCS) 2014; P5-19-27.
    PubMed
  • 37 ClinicalTrials.gov Identifier: NCT02574455.
    PubMed
  • 38 Emens LA, Kok M, Ojalvo LS. et al. Targeting the programmed cell death-1 pathway in breast and ovarian cancer. Curr Opin Obstet Gynecol 2016; 28: 142-147
    CrossrefPubMedSuche in Google Scholar
  • 39 Gao R, Davis A, McDonald TO. et al. Punctuated copy number evolution and clonal stasis in triple-negative breast cancer. Nat Genet 2016; 48: 1119-1130
    CrossrefPubMedSuche in Google Scholar
  • 40 Pruneri G, Vingiani A, Bagnardi V. et al. Clinical validity of tumor-infiltrating lymphocytes analysis in patients with triple-negative breast cancer. Ann Oncol 2016; 27: 249-256
    CrossrefPubMedSuche in Google Scholar
  • 41 Pruneri G, Vingiani A, Denkert C. Tumor infiltrating lymphocytes in early breast cancer. The Breast 2018; 37: 207e214 doi:10.1016/j.breast.2017.03.010
    PubMedSuche in Google Scholar
  • 42 Loi S, Michiels S, Salgado R. et al. Tumor infiltrating lymphocytes are prognostic in triple negative breast cancer and predictive for trastuzumab benefit in early breast cancer: results from the FinHER Trial. Ann Oncol 2014; 25: 1544-1550
    CrossrefPubMedSuche in Google Scholar
  • 43 Adams S, Gray RJ, Demaria S. et al. Prognostic Value of Tumor-Infiltrating Lymphocytes in Triple-Negative Breast Cancer From Two Phase III Randomized Adjuvant Breast Cancer Trials: ECOG 2197 and ECOG 1199. J Clin Oncol 2014; 32: 2959-2966
    CrossrefPubMedSuche in Google Scholar
  • 44 Denkert C, von Minckwitz G, Brase JC. et al. Tumor-infiltrating lymphocytes and response to neoadjuvant chemotherapy with and without carboplatin in human epidermal growth factor receptor 1-positive and triple-negative primary breast cancers. J Clin Oncol 2015; 33: 983-991
    CrossrefPubMedSuche in Google Scholar
  • 45 Würfel F, Erber R, Huebner H. et al. TILGen: A Program to Investigate Immune Targets in Breast Cancer Patients – First Results on the Influence of Tumor-Infiltrating Lymphocytes. Breast Care (Basel) 2018; 13: 8-14
    CrossrefPubMedSuche in Google Scholar
  • 46 Denkert C, von Minckwitz G, Darb-Esfahani S. et al. Tumour-infiltrating lymphocytes and prognosis in different subtypes of breast cancer: a pooled analysis of 3771 patients treated with neoadjuvant therapy. Lancet Oncol 2018; 19: 40-50
    CrossrefPubMedSuche in Google Scholar
  • 47 Mayer IA, Abramson VG, Lehmann BD. et al. New strategies for triple-negative cancer – deciphering the heterogeneity. Clin Cancer Res 2014; 20: 787-790
    PubMedSuche in Google Scholar
  • 48 Loibl S, Untch M, Burchardi N. et al. Randomized phase II neoadjuvant study (GeparNuevo) to investigate the addition of durvalumab to a taxane-anthracycline containing chemotherapy in triple negative breast cancer. ASCO J Clin Oncol 2018; 36 (Suppl.) Abstr. 104
    PubMedSuche in Google Scholar
  • 49 Schmid P, Adams S, Rugo HS. et al. Atezolizumab and Nab-Paclitaxel in Advanced Triple-Negative Breast Cancer. N Engl J Med 2018; 379: 2108-2121
    CrossrefPubMedSuche in Google Scholar
  • 50 Emens LA, Loi S, Rugo HS. et al. Impassion130: Efficacy in immune biomarker subgroups from the global, randomized, double-blind, placebo-controlled, Phase III study of Atezolizumab + nab-paclitaxel in patients with treatment-naïve, locally advanced or metastatic triple-negative breast cancer. SABCS 2018; abstract/oral presentation GS1-04.
    PubMed
  • 51 Hahnen E, Lederer B, Hauke J. et al. Germline Mutation Status, Pathological Complete Response, and Disease-free Survival in Triple-Negative Breast Cancer: Secondary Analysis of the GeparSixto Randomized Clinical Trial. JAMA Oncol 2017; 3: 1378-1385
    CrossrefPubMedSuche in Google Scholar
  • 52 Couch FJ, Hart SN, Sharma P. et al. Inherited mutations in 17 breast cancer susceptibility genes among a large triple-negative breast cancer cohort unselected for family history of breast cancer. J Clin Oncol 2015; 33: 304-311
    PubMedSuche in Google Scholar
  • 53 Fasching PA, Loibl S, Hu C. et al. BRCA1/2 Mutations and Bevacizumab in the Neoadjuvant Treatment of Breast Cancer: Response and Prognosis Results in Patients With Triple-Negative Breast Cancer From the GeparQuinto Study. J Clin Oncol 2018; 36: 2281-2287
    CrossrefPubMedSuche in Google Scholar
  • 54 Lord CJ, Ashworth A. BRCAness revisited. Nat Rev Cancer 2016; 16: 110-120
    CrossrefPubMedSuche in Google Scholar
  • 55 Telli ML, Timms KM, Reid J. et al. Homologous Recombination Deficiency (HRD) Score Predicts Response to Platinum-Containing Neoadjuvant Chemotherapy in Patients with Triple-Negative Breast Cancer. Clin Cancer Res 2016; 22: 3764-3773
    CrossrefPubMedSuche in Google Scholar
  • 56 Loibl S, Weber KE, Timms KM. et al. Survival analysis of carboplatin added to an anthracycline/taxane-based neoadjuvant chemotherapy and HRD score as predictor of response – final results from GeparSixto. Ann Oncol 2018;
    CrossrefPubMedSuche in Google Scholar
  • 57 Copson ER, Maishman TC, Tapper WJ. et al. Germline BRCA mutation and outcome in young-onset breast cancer (POSH). A prospective cohort study. Lancet Oncol 2018; 19: 169-180
    CrossrefPubMedSuche in Google Scholar
  • 58 Tutt A, Tovey H, Cheang MCU. et al. Carboplatin in BRCA1/2-mutated and triple-negative breast cancer BRCAness subgroups: the TNT Trial. Nature Medicine 2018; 24: 628-637
    CrossrefPubMedSuche in Google Scholar
  • 59 Rodler ET, Kurland BR, Griffin M. et al. Phase I Study of Veliparib Combined with Cisplatin and Vinorelbine in Advanced Triple-Negative Breast Cancer and/or BRCA Mutation-Associated Breast Cancer. Clin Cancer Res 2016; 22: 2855-2864
    CrossrefPubMedSuche in Google Scholar
  • 60 Robson M, Im SA, Senkus E. et al. Olaparib for Metastatic Breast Cancer in Patients with a Germline BRCA Mutation. N Engl J Med 2017; 377: 523-533
    CrossrefPubMedSuche in Google Scholar
  • 61 Litton JK, Rugo HS, Ettl J. et al. Talazoparib in Patients with Advanced Breast Cancer and a Germline BRCA Mutation. N Engl J Med 2018; 379: 753-763
    CrossrefPubMedSuche in Google Scholar
  • 62 Loibl S, OʼShaughnessy J, Untch M. et al. Addition of the PARP inhibitor veliparib plus carboplatin or carboplatin alone to standard neoadjuvant chemotherapy in triple-negative breast cancer (BrighTNess). A randomised, phase 3 trial. Lancet Oncol 2018; 19: 497-509
    CrossrefPubMedSuche in Google Scholar
  • 63 Denkert C, Loibl S, Müller BM. et al. Ki67 levels as predictive and prognostic parameters in pretherapeutic breast cancer core biopsies: a translational investigation in the neoadjuvant GeparTrio trial. Ann Oncol 2013; 24: 2786-2793
    CrossrefPubMedSuche in Google Scholar
  • 64 Gray R, Bradley R, Braybrooke J. et al. Increasing the dose density of adjuvant chemotherapy by shortening intervals between courses or by sequential drug administration significantly reduces both disease recurrence and breast cancer mortality: An EBCTCG meta-analysis. SABCS 2017; Abstr. GS1-01.
    PubMed
  • 65 Moebus V, Jackisch C, Lück HJ. et al. Ten-year results of intense dose-dense chemotherapy show superior survival compared with a conventional schedule in high-risk primary breast cancer: final results of AGO phase III iddEPC trial. Ann Oncol 2018; 29: 178-185
    CrossrefPubMedSuche in Google Scholar
  • 66 Sparano JA, Wang M, Martino S. et al. Weekly paclitaxel in the adjuvant treatment of breast cancer. N Engl J Med 2008; 358: 1663-1671
    CrossrefPubMedSuche in Google Scholar
  • 67 Sparano JA, Zhao F, Martino S. et al. Long-Term Follow-Up of the E1199 Phase III Trial Evaluating the Role of Taxane and Schedule in Operable Breast Cancer. J Clin Oncol 2015; 33: 2353-2360
    CrossrefPubMedSuche in Google Scholar
  • 68 von Minckwitz G, Schneeweiss A, Loibl S. et al. Neoadjuvant carboplatin in patients with triple-negative and HER2-positive early breast cancer (GeparSixto; GBG 66): a randomised phase 2 trial. Lancet Oncol 2014; 15: 747-756
    CrossrefPubMedSuche in Google Scholar
  • 69 Sikov WM, Berry DA, Perou CM. et al. Impact of the Addition of Carboplatin and/or Bevacizumab to Neoadjuvant Once-per-Week Paclitaxel Followed by Dose-Dense Doxorubicin and Cyclophosphamide on Pathologic Complete Response Rates in Stage II to III Triple-Negative Breast Cancer: CALGB 40603 (Alliance). J Clin Oncol 2015; 33: 13-21
    PubMedSuche in Google Scholar
  • 70 Schneeweiss A, Möbus V, Tesch H. et al. Intense dose-dense epirubicin, paclitaxel, cyclophosphamide versus weekly paclitaxel, liposomal doxorubicin (plus carboplatin in triple-negative breast cancer) for neoadjuvant treatment of high-risk early breast cancer (GeparOcto-GBG 84): A randomised phase III trial. Eur J Cancer 2018; 106: 181-192
    PubMedSuche in Google Scholar
  • 71 von Minckwitz G, Untch M, Blohmer JU. et al. Definition and impact of pathologic complete response on prognosis after neoadjuvant chemotherapy in various intrinsic breast cancer subtypes. J Clin Oncol 2012; 30: 1796-1804
    CrossrefPubMedSuche in Google Scholar
  • 72 Berruti A, Amoroso V, Gallo F. et al. Pathologic complete response as a potential surrogate for the clinical outcome in patients with breast cancer after neoadjuvant therapy. A metaanalysis of 29 randomized prospective studies. J Clin Oncol 2014; 32: 3883-3891
    CrossrefPubMedSuche in Google Scholar
  • 73 Symmans WF, Wei C, Gould R. et al. Long-Term Prognostic Risk After Neoadjuvant Chemotherapy Associated With Residual Cancer Burden and Breast Cancer Subtype. J Clin Oncol 2017; 35: 1049-1060
    CrossrefPubMedSuche in Google Scholar
  • 74 Masuda N, Lee S-J, Ohtani S. et al. Adjuvant Capecitabine for Breast Cancer after Preoperative Chemotherapy. N Engl J Med 2017; 376: 2147-2156
    CrossrefPubMedSuche in Google Scholar
  • 75 Zujewski JA, Rubinstein L. CREATE-X a role for capecitabine in early-stage breast cancer: an analysis of available data. NPJ Breast Cancer 2017; 3: 27
    CrossrefPubMedSuche in Google Scholar
  • 76 Untch M, Jackisch C, Schneeweiss A. et al. Nab-paclitaxel versus solvent-based paclitaxel in neoadjuvant chemotherapy for early breast cancer (GeparSepto-GBG 69): a randomised, phase 3 trial. Lancet Oncol 2016; 17: 345-356
    CrossrefPubMedSuche in Google Scholar
  • 77 von Minckwitz G. Early survival analysis of the randomised phase II trial investigating the addition of carboplatin to neoadjuvant therapy for triple-negative and HER2-positive early breast cancer (GeparSixto). SABCS2015; Abstr. S2-04.
    PubMed
  • 78 Petrelli F, Coinu A, Borgonovo K. et al. The value of platinum agents as neoadjuvant chemotherapy in triple-negative breast cancers: a systematic review and meta-analysis. Breast Cancer Res Treat 2014; 144: 223-232
    CrossrefPubMedSuche in Google Scholar
  • 79 Wunderle M, Gass P, Häberle L. et al. BRCA mutations and their influence on pathological complete response and prognosis in a clinical cohort of neoadjuvantly treated breast cancer patients. Breast Cancer Res Treat 2018; 171: 85-94
    CrossrefPubMedSuche in Google Scholar
  • 80 Paluch-Shimon S, Friedman E, Berger R. et al. Neo-adjuvant doxorubicin and cyclophosphamide followed by paclitaxel in triple-negative breast cancer among BRCA1 mutation carriers and non-carriers. Breast Cancer Res Treat 2016; 157: 157-165
    CrossrefPubMedSuche in Google Scholar
  • 81 Gluz O, Nitz U, Liedtke C. et al. Comparison of Neoadjuvant Nab-Paclitaxel+Carboplatin vs Nab-Paclitaxel+Gemcitabine in Triple-Negative Breast Cancer: Randomized WSG-ADAPT-TN Trial Results. J Natl Cancer Inst 2018; 110: 628-637
    CrossrefPubMedSuche in Google Scholar
  • 82 Gluz O, Nitz U, Liedtke C. et al. Prognostic impact of anthracyclines and immune/proliferation markers in TNBC according to pCR after de-escalated neoadjuvant chemotherapy with 12 weeks og nab-paclitaxel/carboplatin or gemcitabine: Survival results of WSG-ADAPT-TN phase II trial. ESMO 2018; München, Poster.
    PubMed
  • 83 National Comprehensive Cancer Network (NCCN). Breast Cancer. Online: https://www.nccn.org/professionals/physician_gls/default.aspx last access: 15.01.2019
    PubMed
  • 84 Therapieempfehlungen der Amerikanischen Gesellschaft für klinische Onkologie (ASCO). Online: https://www.asco.org/practice-guidelines/quality-guidelines/guidelines/breast-cancer European Society for medical oncology; last access: 15.01.2019
    PubMed
  • 85 ESMO. International Consensus Guidelines for Advanced Breast Cancer (ABC3). Online: https://www.esmo.org/Guidelines/Breast-Cancer last access: 15.01.2019 oder: Cardoso F, Costa A, Senkus E. et al. 3rd ESO-ESMO International Consensus Guidelines for Advanced Breast Cancer (ABC3). Ann Oncol 2017; 28: 16-33 doi:10.1093/annonc/mdw544
    CrossrefPubMedSuche in Google Scholar
  • 86 Wapnir IR, Price KN, Anderson SJ. et al. Efficacy of Chemotherapy for ER-Negative and ER-Positive Isolated Locoregional Recurrence of Breast Cancer. Final Analysis of the CALOR Trial. N Engl J Med 2018; 36: 1073-1079
    PubMedSuche in Google Scholar
  • 87 Coombe R, Lisy K, Campbell J. et al. Survival outcomes following aggressive treatment of oligometastatic breast cancer: a systematic review protocol. JBI Database System Rev Implement Rep 2017; 15: 2013-2019
    CrossrefPubMedSuche in Google Scholar
  • 88 Rugo HS, Barry WT, Moreno-Aspitia A. et al. Randomized phase III trial of paclitaxel once per week compared with nanoparticle albumin-bound nab-paclitaxel once per week or ixabepilone with bevacizumab as first-line chemotherapy for locally recurrent or metastatic breast cancer: CALGB 40502/NCCTG N063H (alliance). J Clin Oncol 2015; 33: 2361-2369
    CrossrefPubMedSuche in Google Scholar
  • 89 Hamilton E, Kimmick G, Hopkins J. et al. Nab-paclitaxel/bevacizumab/carboplatin chemotherapy in first-line triple negative metastatic breast cancer. Clin Breast Cancer 2013; 13: 416-420
    CrossrefPubMedSuche in Google Scholar
  • 90 Lobo C, Lopes G, Baez O. et al. Final results of a phase II study of nab-paclitaxel, bevacizumab and gemcitabine as first-line therapy for patients with HER2-negative metastatic breast cancer. Breast Cancer Res Treat 2010; 123: 427-435
    CrossrefPubMedSuche in Google Scholar
  • 91 Yardley DA, Coleman R, Conte P. et al. nab-Paclitaxel plus carboplatin or gemcitabine versus gemcitabine plus carboplatin as first-line treatment of patients with triple-negative metastatic breast cancer: results from the tnAcity trial. Ann Oncol 2018; 29: 1763-1770
    CrossrefPubMedSuche in Google Scholar
  • 92 Fachinformation Abraxane® 5 mg/ml, Stand: Juli 2018.
    PubMed
  • 93 Dent R, Andre F, Goncalves A. et al. IMpassion132: A double-blind randomized phase 3 trial evaluating chemotherapy (CT) ± atezolizumab (atezo) for early progressing locally advanced/metastatic triple-negative breast cancer (mTNBC). ASCO J Clin Oncol 2018; 36 (Suppl.) TPS1115
    PubMedSuche in Google Scholar
  • 94 ClinicalTrials.gov Identifier: NCT02620280.
    PubMed
  • 95 Online: https://www.gbg.de/de/studien/gepardouze.php last access: 20.01.2019
    PubMed
  • 96 ClinicalTrials.gov Identifier: NCT01997333.
    PubMed
  • 97 Stirrups R. Sacituzumab govitecan-hziy for triple-negative breast cancer. Lancet Oncol 2019; pii:S1470-2045(19)30074-9 doi:10.1016/S1470-2045(19)30074-9
    PubMedSuche in Google Scholar
  • 98 Bardia A, Mayer IA, Vahdat LT. et al. Sacituzumab Govitecan-hiziy in Refractory Metastatic Triple-Negative Breast Cancer. N Engl J Med 2019; 380: 741-751
    CrossrefPubMedSuche in Google Scholar
  • 99 ClinicalTrials.gov Identifier: NCT02338167.
    PubMed
  • 100 Fasching PA, Brucker SY, Fehm TN. et al. Biomarkers in Patients with Metastatic Breast Cancer and the PRAEGNANT Study Network. Geburtsh Frauenheilk 2015; 75: 41-50
    Thieme ConnectPubMedSuche in Google Scholar
  • 101 Online: http://www.gbg.de/de/Studien/aurora.php last access: 20.01.2019
    PubMed