Abstract
The purpose of this study was to conduct an up-to-date systematic review and meta-analysis
of radiographic knee osteoarthritis (OA) over minimal ten years after ACL reconstruction.
The database of Pubmed and the Ovid was adopted. The radiographic knee OA over minimal
ten years after ACL reconstruction was systematically reviewed. Both the ipsilateral
and contralateral knees were evaluated referring to the tibiofemoral joint (TFJ),
the patellofemoral joint (PFJ), and the overall knee OA prevalence. Nineteen studies
were included for review, with nine screened for the meta-analysis. The overall knee
OA rate ranged from 8.3–79.2%, meanly 51.6% on the ipsilateral side; ranged from 3.6–35.7%,
meanly 15.5% on the contralateral side. Compared to the contralateral side, the RR
of developing radiographic OA was 3.73 (P<0.01) for the overall knee, 2.88 (P<0.01)
for TFJ, and 2.42 (P<0.01) for PFJ. Ipsilaterally, the RR of developing TFJ radiographic
OA was 1.15 (P<0.01) compared to that of the PFJ. Over a minimum of 10 years after
surgery, more than half the cases developed overall radiographic OA on the ipsilateral
knee, which was nearly four times higher than the contralateral side. On the ipsilateral
knee, the TFJ was most affected.
Key words
anterior cruciate ligament reconstruction - osteoarthritis - long-term - meta-analysis
