Download PDF
Kinder- und Jugendmedizin 2019; 19(04): 247-256
DOI: 10.1055/a-0918-1275
Übersichtsarbeit
© Georg Thieme Verlag KG Stuttgart · New York

Update Allergologie im Kindesalter

Update allergology in childhood
Nicola Wagner∗
1   Hautklinik, Universitätsklinik Erlangen
,
Michael Sticherling∗
1   Hautklinik, Universitätsklinik Erlangen
› Author Affiliations
Further Information

Publication History

eingereicht 06 September 2018

akzeptiert 12 September 2018

Publication Date:
16 August 2019 (online)

Also available at
   Permissions and Reprints

Zusammenfassung

Allergologische Erkrankungen im Kindesalter manifestieren sich mit diversen Symptomen. Das zunehmend breitere Spektrum verfügbarer spezifischer IgE auf rekombinante Allergene verbessert die Diagnostik und die Beurteilung ätiologischer Zusammenhänge einer allergologischen Symptomatik. Nahrungsmittelassoziierte Allergien und Intoleranzen nehmen zu und erfordern, insbesondere im Kindesalter, eine rasche Aufklärung des auslösenden Allergens. Die Empfehlungen zur allergologischen Diagnostik bei Arzneimittelallergie-/unverträglichkeit stehen als deutsche SK2-Leitlinie zur Verfügung. Ekzematöse Hautveränderungen können neben Atopie-assoziierten Ekzemreaktionen auch auf Kontaktallergien zurückzuführen sein, weshalb auch neue Kontaktallergene, wie Isobornylacrylat, in kontinuierlich messenden Glukosesensoren, differenzialdiagnostisch bedacht werden sollten.

Abstract

Allergologic diseases in childhood present with various clinical symptoms. The broadening spectre of specific IgE to recombinant allergens refines diagnostic tools and helps to understand aetiological relationship of allergic symptoms. Food-associated allergies and intolerances are increasing and require, especially in childhood, a rapid clarification of the culprit allergen. Recommendations in diagnostics of drug allergy are summarized in a recent german guideline. Eczema often is atopy associated but might be the clinical symptom of contact allergy. New emerging contact allergens, as isobornylacrylate in continuous glucose monitoring devices, should be taken into account.

Schlüsselwörter

Nahrungsmittelallergie - Medikamentenallergie - eosinophile Ösophagitis-Kontaktallergie

Key words

Food allergy - drug allergy - eosinophilic esophagitis-contact allergy
 

  • Literaturverzeichnis

  • 1 Aberer W, Bircher A, Romano A. et al. Drug provocation testing in the diagnosis of drug hypersensitivity reactions: general considerations.. Allergy 2003; 58: 854-863
    CrossrefPubMedGoogle Scholar
  • 2 Andersson AM, Opstrup MS, Zachariae C. et al. The importance of a complete declaration of isothiazolinones in products beyond cosmetics.. Contact Dermatitis 2017; 77: 171-172
    CrossrefPubMedGoogle Scholar
  • 3 Atanasković-Marković M, Velicković TC, Gavrović-Jankulović M. et al. Immediate allergic reactions to cephalosporins and penicillins and their cross-reactivity in children.. Pediatr Allergy Immunol 2005; 16: 341-347
    CrossrefPubMedGoogle Scholar
  • 4 Blank S, Bilò MB, Ollert M.. Component-resolved diagnostics to direct in venom immunotherapy: Important steps towards precision medicine.. Clin Exp Allergy 2018; 48: 354-364
    CrossrefPubMedGoogle Scholar
  • 5 Boonstra M, Rustemeyer T, Middelkamp-Hup MA.. Both children and adult patients with difficult-to-treat atopic dermatitis have high prevalences of concomitant allergic contact dermatitis and are frequently polysensitized.. J Eur Acad Dermatol Venereol 2018; 32: 1554-1561
    CrossrefPubMedGoogle Scholar
  • 6 Brockow K, Przybilla B, Aberer W. et al. Guideline for the diagnosis of drug hypersensitivity reactions: S2K-Guideline of the German Society for Allergology and Clinical Immunology (DGAKI) and the German Dermatological Society (DDG) in collaboration with the Association of German Allergologists (AeDA), the German Society for Pediatric Allergology and Environmental Medicine (GPA), the German Contact Dermatitis Research Group (DKG), the Swiss Society for Allergy and Immunology (SGAI), the Austrian Society for Allergology and Immunology (ÖGAI), the German Academy of Allergology and Environmental Medicine (DAAU), the German Center for Documentation of Severe Skin Reactions and the German Federal Institute for Drugs and Medical Products (BfArM).. Allergo J Int 2015; 24: 94-105
    PubMedGoogle Scholar
  • 7 Casey JR, Pichichero ME.. Acellular pertussis vaccine safety and efficacy in children, adolescents and adults.. Drugs 2005; 65: 1367-1389
    CrossrefPubMedGoogle Scholar
  • 8 Gomes ER, Brockow K, Kuyucu S. et al. ENDA/EAACI Drug Allergy Interest Group. Drug hypersensitivity in children: report from the pediatric task force of the EAACI Drug Allergy Interest Group.. Allergy 2016; 71: 149-161
    CrossrefPubMedGoogle Scholar
  • 9 Grüber C, Ankermann T, Bauer C-P. et al. Impfung von Kindern mit erhöhtem Allergierisiko.. Monatsschr Kinderheilkd 2016; 64: 52-58
    Google Scholar
  • 10 Hausen BM, Kaatz M, Jappe U. et al. Para/p-Phenylendiamin-Kontaktallergie: Folgenschwere Dermatosen nach Henna-Tätowierungen.. Dtsch Arztebl 2001; 98: A-1822-1825
    Google Scholar
  • 11 Herman A, Aerts O, Baeck M. et al. Allergic contact dermatitis caused by isobornyl acrylate in Freestyle® Libre, a newly introduced glucose sensor.. Contact Dermatitis 2017; 77: 367-373
    CrossrefPubMedGoogle Scholar
  • 12 Hofmann SC, Fischer J, Eriksson C. et al. IgE detection to α/β/γ-gliadin and its clinical relevance in wheat-dependent exercise-induced anaphylaxis.. Allergy 2012; 67: 1457-1460
    CrossrefPubMedGoogle Scholar
  • 13 Ibia EO, Schwartz RH, Wiedermann BL.. Antibiotic rashes in children: a survey in a private practice setting.. Arch Dermatol 2000; 136: 849-854
    PubMedGoogle Scholar
  • 14 Isaksson M, Ohlhardt S, Radehed J, Svensson A.. Children with atopic dermatitis should always be patch-tested if they have hand or foot dermatitis.. Acta Derm Venereol 2015; 95: 583-586
    Google Scholar
  • 15 Jakob SE, Admanis S.. iPAD-Increasing nickel exposure in children.. Pediatrics 2014; 134: e580-e582
    CrossrefPubMedGoogle Scholar
  • 16 Johansen JD, Aalto-Korte K, Agner T. et al. European Society of Contact Dermatitis guideline for diagnostic patch testing – recommendations on best practice.. Contact Dermatitis 2015; 73: 195-221
    CrossrefPubMedGoogle Scholar
  • 17 Kennedy JL, Stallings AP, Platts-Mills TA. et al. Galactose-α-1,3-galactose and delayed anaphylaxis, angioedema, and urticaria in children.. Pediatrics 2013; 131: e1545-1552
    CrossrefPubMedGoogle Scholar
  • 18 Kopp MV, Niggemann B, Forster J.. House dust mite allergy: complete removal of the provoking allergen is a primary therapeutic approach.. Allergy 2009; 64: 1402-1403
    CrossrefPubMedGoogle Scholar
  • 19 Lange L.. Arzneimittelallergien bei Kindern. Eine allergologische Testung ist immer notwendig.. Hautnah Dermatologie 2016; 32: 36-42
    Google Scholar
  • 20 Lestringant GG, Beuer A, Frossard PM.. Cutaneous reactions to henna and associated additives.. Br J Dermatol 1999; 141: 598-600
    CrossrefPubMedGoogle Scholar
  • 21 Liacouras CA, Furuta GT, Hirano I. et al. Eosinophilic esophagitis: updated consensus recommendations for children and adults.. J Allergy Clin Immunol 2011; 128: 3-20
    CrossrefPubMedGoogle Scholar
  • 22 Lucendo AJ, Molina-Infante J, Arias Á. et al. Guidelines on eosinophilic esophagitis: evidence-based statements and recommendations for diagnosis and management in children and adults.. United European Gastroenterol J 2017; 5: 335-358
    CrossrefPubMedGoogle Scholar
  • 23 Munoz-Persy M, Lucendo AJ.. Treatment of eosinophilic esophagitis in the pediatric patient: an evidence-based approach.. Eur J Pediatr 2018; 177: 649-663
    CrossrefPubMedGoogle Scholar
  • 24 Ortiz Salvador JM, Esteve Martínez A, Subiabre Ferrer D. et al. Para-phenylenediamine allergic contact dermatitis due to henna tattoos in a child and adolescent population.. An Pediatr 2017; 86: 122-126
    CrossrefPubMedGoogle Scholar
  • 25 Pfaar O, Bachert C, Bufe A.. Guideline on allergen-specific immunotherapy in IgE-mediated allergic diseases. S2k Guideline of the German Society for Allergology and Clinical Immunology (DGAKI), the Society for Pediatric Allergy and Environmental Medicine (GPA), the Medical Association of German Allergologists (AeDA), the Austrian Society for Allergy and Immunology (ÖGAI), the Swiss Society for Allergy and Immunology (SGAI), the German Society of Dermatology (DDG), the German Society of Oto- Rhino-Laryngology, Head and Neck Surgery (DGHNO-KHC), the German Society of Pediatrics and Adolescent Medicine (DGKJ), the Society for Pediatric Pneumology (GPP), the German Respiratory Society (DGP), the German Association of ENT Surgeons (BV-HNO), the Professional Federation of Paediatricians and Youth Doctors (BVKJ), the Federal Association of Pulmonologists (BDP) and the German Dermatologists Association (BVDD).. Allergo J Int 2014; 23: 282-319
    CrossrefPubMedGoogle Scholar
  • 26 Philpott H, Thien F.. The Role of Allergy Testing in Eosinophilic Esophagitis: an Update of the Evidence.. Curr Treat Options Gastroenterol 2017; 15: 26-34
    CrossrefPubMedGoogle Scholar
  • 27 Pichler W, Yawalkar N, Schmid S, Helbling A.. Pathogenesis of drug-induced exanthems.. Allergy 2002; 57: 884-893
    CrossrefPubMedGoogle Scholar
  • 28 Przybilla B, Ruëff F, Walker A. et al. Diagnose und Therapie der Bienen- und Wespengiftallergie Leitlinie der Deutschen Gesellschaft für Allergologie und klinische Immunologie (DGAKI), des Ärzteverbandes Deutscher Allergologen (ÄDA), der Gesellschaft für Pädiatrische Allergologie und Umweltmedizin (GPA), der Deutschen Dermatologischen Gesellschaft (DDG) und der Deutschen Gesellschaft für Kinder und Jugendmedizin (DGKJ) in Zusammenarbeit mit der Österreichischen Gesellschaft für Allergo logie und Immunologie (ÖGAI) und der Schweizerischen Gesellschaft für Allergologie und Immunologie (SGAI).. Allergo J 2011; 20: 318-339
    CrossrefGoogle Scholar
  • 29 Roehr CC, Edenharter G, Reimann S. et al. Food allergy and non-allergic food hypersensitivity in children and adolescents.. Clin Exp Allergy 2004; 34: 1534-1541
    CrossrefPubMedGoogle Scholar
  • 30 Scherf KA, Brockow K, Biedermann T. et al. Wheat-dependent exercise-induced anaphylaxis.. Clin Exp Allergy 2016; 46: 10-20
    CrossrefPubMedGoogle Scholar
  • 31 Schmitz R, Thamm M, Ellert U. et al. Verbreitung häufiger Allergien bei Kindern und Jugendlichen in Deutschland: Ergebnisse der KiGGS-Studie-Erste Folgebefragung (KiGGS Welle 1).. Bundesgesundheitsblatt Gesundheitsforschung Gesundheitsschutz 57: 771-778
    Google Scholar
  • 32 Schwensen JF, Friis UF, Zachariae C, Johansen JD.. Sensitization to cyanoacrylates caused by prolonged exposure to a glucose sensor set in a diabetic child.. Contact Dermatitis 2016; 74: 124-125
    CrossrefPubMedGoogle Scholar
  • 33 Uter W, Gefeller O, Geier JA.. Methylchloroisothiazolinone/methylisothiazolinone contact sensitization: diverging trends in subgroups of IVDK patients in a period of 19 years.. Contact Dermatitis 2012; 67: 125-129
    CrossrefPubMedGoogle Scholar
  • 34 Werfel T, Ballmer-Weber B, Eigenmann PA. et al. Eczematous reactions to food in atopic eczema: position paper of the EAACI and GA2LEN.. Allergy 2007; 62: 723-728
    CrossrefPubMedGoogle Scholar
  • 35 Worm M, Aberer W, Agathos M. et al. Patch testing in children -recommendations of the German Contact Dermatitis Research Group (DKG).. J Dtsch Dermatol Ges 2007; 5: 107-109
    CrossrefPubMedGoogle Scholar
  • 36 Worm M, Jappe U, Kleine-Tebbe J. et al. Food allergies resulting from immunological cross-reactivity with inhalant allergens: Guidelines from the German Society for Allergology and Clinical Immunology (DGAKI), the German Dermatology Society (DDG), the Association of German Allergologists (AeDA) and the Society for Pediatric Allergology and Environmental Medicine (GPA).. Allergo J Int 2014; 23: 1-16
    CrossrefPubMedGoogle Scholar
  • 37 Worm M, Reese I, Ballmer-Weber B. et al. Leitlinie zum Management IgE-vermittelter Nahrunsgmittelallergien.. Allergo J Int 2015; 24: 256
    CrossrefPubMedGoogle Scholar
  • 38 Worm M, Lippert U, Geier J, Schnuch A.. Kontaktallergien im Kindesalter.. Hautarzt 2015; 66: 646-651
    CrossrefPubMedGoogle Scholar
  • 39 Valentine MD, Schuberth KC, Kagey-Sobotka A. et al. The value of immunotherapy with venom in children with allergy to insect stings.. N Engl J Med 1990; 323: 1601-1603
    CrossrefPubMedGoogle Scholar
  • 40 Zuberbier T, Edenharter G, Worm M. et al. Prevalence of adverse reactions to food in Germany – a population study.. Allergy 2004; 59: 338-345
    CrossrefPubMedGoogle Scholar