Subscribe to RSS
DOI: 10.1055/a-0921-7374
Geographic Clusters of Underimmunization Against Influenza in the Elderly: Westphalia-Lippe as an Example
Article in several languages: deutsch | EnglishAuthors

Abstract
Background Underimmunization against influenza has been increasing in recent years. A spatial clustering of underimmunization is suspected. These clusters can pose risks to health care and make achieving immunization quality standards difficult. The objectives of this paper are to (a) identify and describe PLZ-level spatial clusters with high levels of underimmunization against influenza, (b) compare the clusters with other preventive services, and (c) model possible factors influencing underimmunization.
Material and methods From the routine data of the Association of Statutory Health Insurance physicians Westphalia-Lippe, patients ≥60 years and vaccinations between 2012–2017 were extracted. As a methodology, the spatial scan statistics were chosen, which show high relative risks of underimmunization in clusters.
Results and conclusion Four statistically significant clusters of underimmunization against influenza were identified, which proved to be stable even after adjustment with the temporal trend of local underimmunization rates. In the flu season 2016/2017, the underimmunization rate in the higher risk clusters (RR>1) was 71.9–74.7% and the rate outside these clusters was 67.0%. As influencing factors on underimmunization, socio-economic factors and vaccination behavior in the preseason were identified. Underimmunization rates are geographically clustered. The spatial scan statistics can be used for the identification of persistent clusters in order to carry out targeted spatial and addressee-specific measures to reduce underimmunization rates.
Publication History
Article published online:
23 August 2019
© 2019. Thieme. All rights reserved.
Georg Thieme Verlag KG
Rüdigerstraße 14, 70469 Stuttgart, Germany
- 
            References
- 1 Robert Koch-Institut. Bericht zur Epidemiologie der Influenza in Deutschland,
            Saison 2017/18, Berlin 2018 
            Reference Ris Wihthout Link
- 2 Robert Koch Institut. Empfehlungen der Ständigen Impfkommission (STIKO) am RKI
            2018/2019. Epidemiol Bull 2018; 34: 333-382 
            Reference Ris Wihthout Link
- 3 World Health Organisation (WHO). WHO position paper on influenza vaccines. Wkly Epidemiol
            Rec 2005; 80: 279-287 
            Reference Ris Wihthout Link
- 4 
            
            Reuss AM, 
            
            
            Walter D, 
            
            
            Feig M. 
            
            et al. Influenzaimpfquoten der Saisons 2004/05, 2005/06 und
            2006/07. Eine Sekundärdatenanalyse von Abrechnungsdaten der
            Kassenärztlichen Vereinigungen. Dtsch Ärztebl Int 2010; 107: 845-850 
            Reference Ris Wihthout Link
- 5 Bätzing-Feigenbaum J, Schulz et al. der saisonalen
            Influenzastandardimpfraten im kassenärztlichen Versorgungssektor in
            Deutschland seit der Pandemie 2009 – eine Trendanalyse auf regionaler
            Ebene für den Zeitraum 2009/2010 bis 2013/2014.
            Zentralinstitut für die kassenärztliche Versorgung in
            Deutschland (Zi). Versorgungsatlas-Bericht Nr. 15/19. Berlin 2015 
            Reference Ris Wihthout Link
- 6 
            
            Gravenstein S, 
            
            
            Davidson HE, 
            
            
            Taljaard M. 
            
            et al. Comparative effectiveness of high-dose versus standard-dose influenza
            vaccination on numbers of US nursing home residents admitted to hospital: a
            cluster-randomised trial. Lancet. Respir Med 2017; 5: 738-746 
            Reference Ris Wihthout Link
- 7 
            
            Nichol KL, 
            
            
            Goodman M. 
            
            The health and economic benefits of influenza vaccination for healthy and
            at-risk persons aged 65 to 74 years. PharmacoEconomics 1999; 16: 63-71 
            Reference Ris Wihthout Link
- 8 
            
            Kitron U, 
            
            
            Kazmierczak JJ. 
            
            Spatial Analysis of the Distribution of Lyme Disease in Wisconsin. Am J Epidemiol
            1997; 145: 558-566 
            Reference Ris Wihthout Link
- 9 
            
            Kleinman K, 
            
            
            Lazarus R, 
            
            
            Platt R. 
            
            A Generalized Linear Mixed Models Approach for Detecting Incident Clusters of
            Disease in Small Areas, with an Application to Biological Terrorism. Am J Epidemiol
            2004; 159: 217-224 
            Reference Ris Wihthout Link
- 10 
            
            Wen T-H, 
            
            
            Lin NH, 
            
            
            Chao D-Y. 
            
            et al. Spatial–temporal patterns of dengue in areas at risk of dengue
            hemorrhagic fever in Kaohsiung, Taiwan, 2002. Int J Infect Dis 2010; 14: e334-e343
            
            Reference Ris Wihthout Link
- 11 
            
            Lieu TA, 
            
            
            Ray GT, 
            
            
            Klein NP. 
            
            et al. Geographic clusters in underimmunization and vaccine refusal. Pediatrics 2015;
            135: 280-289 
            Reference Ris Wihthout Link
- 12 
            
            Anselin L. 
            
            Local Indicators of Spatial Association – LISA. Geogr Anal 1995; 27: 93-115 
            Reference Ris Wihthout Link
- 13 
            
            Fritz CE, 
            
            
            Schuurman N, 
            
            
            Robertson C. 
            
            et al. A scoping review of spatial cluster analysis techniques for point-event
            data. Geospatial Health 2013; 7: 183-198 
            Reference Ris Wihthout Link
- 14 
            
            Kulldorff M, 
            
            
            Nagarwalla N. 
            
            Spatial disease clusters: detection and inference. Stat Med 1995; 14: 799-810 
            Reference Ris Wihthout Link
- 15 
            
            Kulldorff M. 
            
            A spatial scan statistic. Commun Stat – Theory Methods 1997; 26: 1481-1496 
            Reference Ris Wihthout Link
- 16 
            
            Jorgensen P, 
            
            
            Mereckiene J, 
            
            
            Cotter S. 
            
            et al. How close are countries of the WHO European Region to achieving the goal of
            vaccinating 75% of key risk groups against influenza? Results from
            national surveys on seasonal influenza vaccination programmes, 2008/2009
            to 2014/2015. Vaccine 2018; 36: 442-452 
            Reference Ris Wihthout Link
- 17 Völker S Die Inanspruchnahme der ambulanten Notfallversorgung in
            Westfalen-Lippe: eine medizingeographische Studie. Gesundheitswesen 2017; Im
            Internet:
            http://www.thieme-connect.de/DOI/DOI?10.1055/s-0043-119082 
            Reference Ris Wihthout Link
- 18 
            
            Omer SB, 
            
            
            Enger KS, 
            
            
            Moulton LH. 
            
            et al. Geographic Clustering of Nonmedical Exemptions to School Immunization
            Requirements and Associations With Geographic Clustering of Pertussis. Am J Epidemiol
            2008; 168: 1389-1396 
            Reference Ris Wihthout Link
- 19 
            
            Pfeiffer DU, 
            
            
            Minh PQ, 
            
            
            Martin V. 
            
            et al. An analysis of the spatial and temporal patterns of highly pathogenic avian
            influenza occurrence in Vietnam using national surveillance data. Vet J 2007; 174:
            302-309 
            Reference Ris Wihthout Link
- 20 
            
            Bödeker B, 
            
            
            Remschmidt C, 
            
            
            Schmich P. 
            
            et al. Why are older adults and individuals with underlying chronic diseases in Germany
            not vaccinated against flu? A population-based study. BMC Public Health 2015; 15:
            618 
            Reference Ris Wihthout Link
- 21 
            
            Eastwood K, 
            
            
            Durrheim D, 
            
            
            Francis JL. 
            
            et al. Knowledge about pandemic influenza and compliance with containment measures
            among Australians. Bull World Health Organ 2009; 87: 588-594 
            Reference Ris Wihthout Link
- 22 
            
            Seale H, 
            
            
            Heywood AE, 
            
            
            McLaws M-L. 
            
            et al. need it? I am not at risk! Public perceptions towards the pandemic (H1N1) 2009
            vaccine. BMC Infect Dis 2010; 10: 99 
            Reference Ris Wihthout Link
- 23 
            
            Setbon M, 
            
            
            Raude J. 
            
            Factors in vaccination intention against the pandemic influenza
            A/H1N1. Eur J Public Health 2010; 20: 490-494 
            Reference Ris Wihthout Link
- 24 
            
            Feikin DR, 
            
            
            Lezotte DC, 
            
            
            Hamman RF. 
            
            et al. Individual and Community Risks of Measles and Pertussis Associated With Personal
            Exemptions to Immunization. JAMA 2000; 284: 3145-3150 
            Reference Ris Wihthout Link
- 25 
            
            Salmon DA, 
            
            
            Haber M, 
            
            
            Gangarosa EJ. 
            
            et al. Health consequences of religious and philosophical exemptions from immunization
            laws: individual and societal risk of measles. JAMA 1999; 282: 47-53 
            Reference Ris Wihthout Link
- 26 
            
            Andrew MK, 
            
            
            McNeil S, 
            
            
            Merry H. 
            
            et al. Rates of influenza vaccination in older adults and factors associated with
            vaccine use: A secondary analysis of the Canadian Study of Health and Aging. BMC Public
            Health 2004; 4: 36 
            Reference Ris Wihthout Link
- 27 
            
            Bish A, 
            
            
            Yardley L, 
            
            
            Nicoll A. 
            
            et al. Factors associated with uptake of vaccination against pandemic influenza: a
            systematic review. Vaccine 2011; 29: 6472-6484 
            Reference Ris Wihthout Link
- 28 
            
            Rubin GJ, 
            
            
            Potts HWW, 
            
            
            Michie S. 
            
            The impact of communications about swine flu (influenza A H1N1v) on public
            responses to the outbreak: results from 36 national telephone surveys in the
            UK. Health Technol Assess Winch Engl 2010; 14: 183-266 
            Reference Ris Wihthout Link
- 29 
            
            Vaux S, 
            
            
            Van Cauteren D, 
            
            
            Guthmann J-P. 
            
            et al. Influenza vaccination coverage against seasonal and pandemic influenza and
            their
            determinants in France: a cross-sectional survey. BMC Public Health 2011; 11: 30 
            Reference Ris Wihthout Link
- 30 
            
            Fabry P, 
            
            
            Gagneur A, 
            
            
            Pasquier J-C. 
            
            Determinants of A (H1N1) vaccination: cross-sectional study in a population of
            pregnant women in Quebec. Vaccine 2011; 29: 1824-1829 
            Reference Ris Wihthout Link
- 31 
            
            Gaygısız Ü, 
            
            
            Gaygısız E, 
            
            
            Özkan T. 
            
            et al. Why were Turks unwilling to accept the A/H1N1 influenza-pandemic
            vaccination? Peopleʼs beliefs and perceptions about the swine flu outbreak and
            vaccine in the later stage of the epidemic. Vaccine 2010; 29: 329-333 
            Reference Ris Wihthout Link
- 32 
            
            Ellis SE, 
            
            
            Coffey CS, 
            
            
            Mitchel EF. 
            
            et al. Influenza- and Respiratory Syncytial Virus–Associated Morbidity and
            Mortality in the Nursing Home Population. J Am Geriatr Soc 51: 761-767 
            Reference Ris Wihthout Link
 
     
      
    