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Horm Metab Res 2019; 51(07): 470-482
DOI: 10.1055/a-0926-3618
Review

Precision Surgery for Pheochromocytomas and Paragangliomas

Douglas Wiseman
1   Surgical Oncology Program, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, USA
,
Mustapha El Lakis
1   Surgical Oncology Program, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, USA
,
Naris Nilubol
1   Surgical Oncology Program, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, USA
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Abstract

Since Felix Fränkel’s account of pheochromocytoma in 1886, great discoveries and vast advancements in the diagnosis, genetics, anatomical and functional imaging techniques, and surgical management of pheochromcytoma and paraganglioma (P-PGL) have been made. The improved insight in the pathophysiology of P-PGL and more accurate detection methods enable physicians to tailor the treatment plan to an individual based on the genetic profile and tumor behavior. This review will cover briefly the clinical features, diagnosis, genetic mutations, and imaging modalities that are used to guide current surgical management of these rare and interesting endocrinopathies.

Key words

pheochromocytoma - paraganglioma - precision surgery - clusters - biochemical phenotypes - genetic testing - anatomic and functional imaging


Publication History

Received: 16 April 2018

Accepted: 09 May 2019

Article published online:
15 July 2019

Georg Thieme Verlag
Rüdigerstraße 14,70469 Stuttgart, Germany

 

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