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Int J Sports Med 2019; 40(09): 601-608
DOI: 10.1055/a-0946-1293
Clinical Sciences
© Georg Thieme Verlag KG Stuttgart · New York

Methodological Considerations for a Vascular Function Test Battery

Rachel Kimble
1   Sport, Exercise and Rehabilitation, Northumbria University, Newcastle upon Tyne, United Kingdom of Great Britain and Northern Ireland
,
Karen M. Keane
1   Sport, Exercise and Rehabilitation, Northumbria University, Newcastle upon Tyne, United Kingdom of Great Britain and Northern Ireland
,
John K. Lodge
2   Applied Sciences, Northumbria University, Newcastle upon Tyne, United Kingdom of Great Britain and Northern Ireland
,
Glyn Howatson
1   Sport, Exercise and Rehabilitation, Northumbria University, Newcastle upon Tyne, United Kingdom of Great Britain and Northern Ireland
› Author Affiliations
Further Information

Publication History



accepted 21 May 2019

Publication Date:
15 July 2019 (online)

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Abstract

There is a dearth of information regarding the reliability of non-invasive measures of vascular function taken in a single testing session. This study aimed to determine the test-retest reliability of a test battery of vascular function measures: automated blood pressure (BP), laser Doppler imaging with iontophoresis (LDI), digital volume pulse (DVP), pulse wave velocity (PWV), augmentation index (AIx) measured by pulse wave analysis (PWA) and flow-mediated dilation (FMD) taken within and between sessions. Measures were taken in 21 non-smoking males intra-session and again inter-session (one week apart) to determine repeatability and reproducibility, respectively. There was moderate to excellent repeatability (ICC: 0.53–0.93; CV=2.2–18.1%) and reproducibility (ICC: 0.71–0.96; CV 1.9–14.2%) for BP, DVP stiffness index, PWV, AIx, AIx normalised to heart rate (75 bpm), absolute and percentage FMD. Repeatability of the DVP reflection index was moderate (ICC: 0.64; CV=9.5%) but there was poor reproducibility (ICC: 0.17; CV=15.1%). Moreover, the repeatability and reproducibility of the LDI measures ranged from poor to good (ICC: 0.31–0.84; CV=28.4–36.7%). These data indicated that there was considerable variability in the repeatability and reproducibility of measurements of endothelial function and arterial stiffness taken in a battery of measurements, which needs careful consideration in future research designs.

Key words

endothelial function - arterial stiffness - repeatability - reproducibility
 

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